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Alzheimer disease
Alzheimer disease is the most common cause of degenerative dementia in the elderly. The causes of late-onset Alzheimer disease are unclear; risk factors such as mutations in the APOE gene may be involved. Mutations in three genes have been associated with early-onset Alzheimer disease - APP, PSEN1, and PSEN2. Fly stocks in the Bloomington collection that can be used to study Alzheimer Disease are listed here.

General Information links for Alzheimer disease:
OMIM (see also links in table below)
NIH's Genetics Home Reference - includes links for GHR pages on APOE, APP, PSEN1 and PSEN2
NLM/NIH's Genetic and Rare Disease Information Center
Genes for studying Alzheimer disease
Human gene(s) Human full name Fly gene OMIM link and/or comments
APH1A and APH1B Anterior pharynx defective 1A and 1B anterior pharynx defective 1 (aph-1) gamma-secretase complex member
APP Amyloid beta A4 Precursor Protein beta amyloid protein precursor-like (Appl) Alzheimer disease 1/precursor of peptide found in senile plaques
APLP1 and APLP2 Amyloid beta A4 Precursor-like Protein 1 and 2    
BACE1 beta-site Amyloid beta A4 Precursor Protein-cleaving enzyme 1   beta-secretase
FE65/APBB1 Amyloid beta A4 Precursor Protein-binding, family B, member 1   APP-binding protein
HSD17B10/ERAB hydroxysteroid (17-beta) dehydrogenase 10 scully (scu) multifunctional mitochondrial enzyme
MARK3 Microtubule affinity-regulating kinase 3 par-1 tau kinase
NCSTN Nicastrin nicastrin (nct) gamma-secretase complex member
PSEN1 and PSEN2 Presenilin-1 and Presenilin-2 Presenilin (Psn) Alzheimer disease 3 and 4/gamma-secretase complex member
PEN2/PSENEN Presenilin enhancer 2 presenilin enhancer (pen-2) gamma-secretase complex member
Tau (MAPT) Microtubule-associated protein tau tau neurofibrillary tangle component
Shortcuts to genes in table
aph-1 HSD17B10/ERAB
APP (human) MARK3/Par-1
APP - C99 fragment (human) Nicastrin
APP - Abeta42 fragment (human) Pen-2
APLP2 (human) Presenilin (fly Psn)
Appl Presenilin (human PSEN1 and PSEN2)
BACE1 (human) tau
Fe65 (human) stocks with multiple constructs

Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Fly aph-1 stocks
aph-1 P{TRiP.HMS01693}attP40 38249 Expresses dsRNA for RNAi of aph-1 (FBgn0031458) under the control of UAS.
aph-1 aph-1[D35] 3917 Amino acid replacement R99 results in truncation of the aph-1 protein between transmembrane domains 3 and 4.
aph-1 aph-1[D35] 63242 Amino acid replacement R99 results in truncation of the aph-1 protein between transmembrane domains 3 and 4.
aph-1 aph-1[D35] 63244 Amino acid replacement R99 results in truncation of the aph-1 protein between transmembrane domains 3 and 4.
aph-1 P{UAS-aph-1.V5}3 63217 Expresses V5-tagged aph-1 under the control of UAS.
aph-1 P{UAS-aph-1.V5}2 63216 Expresses V5-tagged aph-1 under the control of UAS.
      Stocks carrying human APP
APP (human) P{UAS-hAPP.Z.Z}attP40 64384 Expresses human APP under UAS control.
APP (human) P{UAS-hAPP.HA}attP40 64385 Expresses human APP protein with a C-terminal HA tag under UAS control.
APP (human) P{UAS-APP695-N-myc}TW6 6700 Expresses human amyloid precursor protein with an amino terminal myc tag under UAS control.
APP (human) P{UAS-APP.YFP}LG 32039 Expresses YFP-tagged human APP under the control of UAS.
APP (human) P{UAS-APP.695.Exel}5 33795 Expresses the 695 amino acid isoform of human APP under the control of UAS.
APP (human) P{UAS-APP.695.Exel}3 33796 Expresses the 695 amino acid isoform of human APP under the control of UAS.
APP (human) PBac{UAS-Abeta.1-40}VK00033 64215 Expresses human Abeta amino acids 1-40 under the control of UAS.
APP (human) PBac{UAS-Abeta.1-42}VK00033 64216 Expresses human Abeta amino acids 1-42 under the control of UAS.
APP - Dutch P{UAS-APP.695.E693Q.Exel}9 33790 Expresses the 695 amino acid isoform of human APP carrying the familial Alzheimer's 'Dutch' mutation (E693Q - amino acid numbering based on APP sequence) under the control of UAS.
APP - Dutch P{UAS-APP.695.E693Q.Exel}5 33789 Expresses the 695 amino acid isoform of human APP carrying the familial Alzheimer's 'Dutch' mutation (E693Q - amino acid numbering based on APP sequence) under the control of UAS.
APP - Dutch and French P{UAS-APP.770.E693Q.V715M.myc.VTR}4 33791 Expresses the 770 amino acid isoform of human APP carrying the familial Alzheimer's 'Dutch' (E693Q) and 'French' (V715M) mutations (amino acid numbering based on APP sequence) under the control of UAS.
APP - Dutch and German P{UAS-APP.770.E693Q.V715A.myc.VTR}3 33792 Expresses the 770 amino acid isoform of human APP carrying the familial Alzheimer's 'Dutch' (E693Q) and 'German' (V715A) mutations (amino acid numbering based on APP sequence) under the control of UAS.
APP - London P{UAS-APP.V717F.LOND}LG 32036 Expresses human APP carrying the London mutation (V717F) under the control of UAS.
APP - Swedish P{UAS-APP695-Swedish-N-myc}TS23 6701 Expresses human amyloid precursor protein with familial Alzheimer mutations and an amino terminal myc tag under UAS control.
APP - Swedish P{UAS-APP.770.K670N.M671L.VTR}3 33793 Expresses the 770 amino acid isoform of human APP carrying the familial Alzheimer's 'Swedish' mutation (K670N and M671L - amino acid numbering based on APP sequence) under the control of UAS.
APP - Swedish P{UAS-APP.770.K670N.M671L.E693G.VTR}7 33794 Expresses the 770 amino acid isoform of human APP carrying the familial Alzheimer's 'Swedish' (K670N, M671L) and 'Arctic' (E693G) mutations (amino acid numbering based on APP sequence) under the control of UAS.
APP - BASS mutant P{UAS-HsapAPP.DeltaBASS}2 29872 UAS sequences control expression of human APP deleted for part of the basolateral sorting signal (amino acids 652 - 656, QYTSI) and tagged N-terminally with myc.
APP - ECD mutant P{UAS-APP.695SPA4CT.T:Myc}XX 6702 Expresses human amyloid precursor protein with a carboxy terminal myc tag and lacking most of the extracellular domain under UAS control.
APP - Go mutant P{UAS-HsapAPP.DeltaGo}3 29873 UAS sequences control expression of human APP deleted for the Go binding site (amino acids 657 - 668, HHGVVEVDAAV) and tagged N-terminally with myc.
APP - ICD mutant P{UAS-HsapAPP.DeltaICD}3 29875 UAS sequences control expression of human APP with EGFP in place of the intracellular domain and tagged N-terminally with myc.
APP - ICD mutant P{UAS-HsapAPP.DeltaICD}2 (2 copies) 29876 UAS sequences control expression of human APP with EGFP in place of the intracellular domain and tagged N-terminally with myc.
APP - ICD mutant P{UAS-APP.695DeltaCT.T:Myc}61 6703 Expresses human amyloid precursor protein with a truncated carboxy terminus and an amino terminal myc tag under UAS control.
APP - NPTY mutant P{UAS-HsapAPP.DeltaNPTY}3c 29868 UAS sequences control expression of human APP deleted for the NPTY internalization sequence and tagged N-terminally with myc.
APP - NPTY mutant P{UAS-HsapAPP.DeltaNPTY}3 (2 copies) 29869 UAS sequences control expression of human APP deleted for the NPTY internalization sequence and tagged N-terminally with myc.
APP - PEER mtuant P{UAS-HsapAPP.DeltaPEER}3 29874 UAS sequences control expression of human APP deleted for amino acids 670 - 679 (PEERHLSKMQ) and tagged N-terminally with myc.
APP (human) PBac{UAS-Abeta.3-42}VK00033 64217 Expresses human Abeta amino acids 3-42 under the control of UAS.
APP (human) PBac{UAS-Abeta.3-42.E3A}VK00033 64222 Expresses human Abeta amino acids 3-42 with the amino acid change E3A under the control of UAS.
APP (human) PBac{UAS-Abeta.11-42}VK00033 64218 Expresses human Abeta amino acids 11-42 under the control of UAS.
APP (human) PBac{UAS-Abeta.11-42.E11A}VK00033 64221 Expresses human Abeta amino acids 11-42 with the amino acid change E11A under the control of UAS.
APP (human) PBac{UAS-Abeta.1-43}VK00033 64219 Expresses human Abeta amino acids 1-43 under the control of UAS.
APP (human) PBac{UAS-Abeta.1-42.A42D}VK00033 64220 Expresses human Abeta amino acids 1-42 with the amino acid change A42D under the control of UAS.
APP (human) PBac{UAS-Abeta.1-38}VK00033 64214 Expresses human Abeta amino acids 1-38 under the control of UAS.
APP - mutant P{UAS-APP.M596I.F615P}2 30092 Expresses human APP, with two amino acid changes designed to reduce cleavage by alpha secretase (M596I and F615P), under UAS control.
APP - N684A P{UAS-HsapAPP.N684A}2 29871 UAS sequences control expression of human APP with the amino acid change N684A and tagged N-terminally with myc.
APP - Y682A P{UAS-HsapAPP.Y682A}2 29870 UAS sequences control expression of human APP with the amino acid change Y682A and tagged N-terminally with myc.
APP/APLP2 P{UAS-HsapAPLP2::HsapAPP.T:Myc}2 30123 Expresses a myc-tagged fusion of human APP and APLP2 under UAS control.
APP-based g-secretase reporter P{GMR-APP-GAL4}2 52016 Expresses a reporter for gamma-secretase activity under GMR control consisting of the human APP transmembrane domain and gamma-secretase cleavage site fused to GAL4.
APP - LV fusion P{UAS-mycAPP.LV}3 30120 Expresses myc-tagged human APP fused C-terminally to LV (LexA DNA binding domain fused to the transcriptional activator VP16) under UAS control.
APP - LV fusion P{UAS-mycAPP.LV}2 30119 Expresses myc-tagged human APP fused C-terminally to LV (LexA DNA binding domain fused to the transcriptional activator VP16) under UAS control.
APP - LV fusion P{UAS-alphaAPP.LV}3 29949 UAS drives expression of truncated human APP (signal peptide fused to the alpha-secretase cleavage site) fused C-terminally to LexA-VP16.
APP and BACE1 P{UAS-BACE1.Exel}7b, P{UAS-APP.695.Exel}1 33797 Expresses human BACE1 and the 695 amino acid isoform of human APP under the control of UAS. Homozygotes may be present.
APP and BACE1 P{UAS-APP695-N-myc}TW6, P{UAS-BACE1.Exel}1b 33798 Expresses human BACE1 and an N-terminally myc-tagged 695 amino acid isoform of human APP under the control of UAS.
APP and tau P{UAS-APP.C99.myc.Exel}21, P{UAS-MAPT.VTR}31K 33803 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag and human MAPT (tau) under UAS control.
APP and tau P{UAS-APP.C99.myc.Exel}19, P{UAS-MAPT.VTR}12B 33801 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag and human MAPT (tau) under UAS control.
APP and tau P{UAS-APP.695.Exel}3, P{UAS-MAPT.VTR}31K 33802 Expresses human MAPT (tau) and the 695 amino acid isoform of human APP under the control of UAS, VTR.
APP, BACE1 and tau P{UAS-MAPT.VTR}54, P{UAS-APP.695.Exel}3, P{UAS-BACE1.Exel}9a 33799 Expresses human MAPT (tau), human BACE1, and the 695 amino acid isoform of human APP under the control of UAS.
APP, BACE1 and tau P{UAS-APP.695.Exel}3, P{UAS-BACE1.Exel}9a, P{UAS-MAPT.VTR}31 33800 Expresses human MAPT (tau), human BACE1, and the 695 amino acid isoform of human APP under the control of UAS.
      Stocks carrying the C99 fragment of human APP
APP/C99 P{UAS-SPA4CT.LV}3 29854 Expresses human APP lacking the N-terminal extracellular domain and fused at its C-terminus to nls2, plus amino acids 2-87 of lexA and amino acids 410-489 of VP16. The product of this construct is intended to mimic the BACE1 cleaved protein isoform of APP
APP/C99 P{UAS-SPA4CT.LV}2 29853 Expresses human APP lacking the N-terminal extracellular domain and fused at its C-terminus to nls2, plus amino acids 2-87 of lexA and amino acids 410-489 of VP16. The product of this construct is intended to mimic the BACE1 cleaved protein isoform of APP
APP/C99 P{UAS-APP.C99.myc.Exel}21 33783 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag under UAS control.
APP/C99 P{UAS-APP.C99.myc.Exel}19 33784 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag under UAS control.
APP/C99 P{UAS-APP.C99.Lcp2sp.HA.Exel}11 33785 Expresses the C99 fragment of APP with a fly signal peptide (from Lcp2) and three copies of an HA tag at the C-terminus under UAS control.
APP/C99 - London P{UAS-APP.C99.V717I.HA.Exel}9 33786 Expresses the C99 fragment of APP carrying the familial Alzheimer's 'London' mutation (V717I - numbering based on APP sequence) with the human APP signal peptide and three copies of an HA tag at the C-terminus under UAS control.
APP/C99 - London P{UAS-APP.C99.V717I.HA.Exel}3B 34533 Expresses the C99 fragment of APP carrying the familial Alzheimer's 'London' mutation (V717I - numbering based on APP sequence) with the human APP signal peptide and three copies of an HA tag at the C-terminus under UAS control.
APP/C99 - mutant P{UAS-APP.C99.YIPLFL.HA.Exel}4a 33788 Expresses the C99 fragment of APP with amino acids YIPLFL substituted for GVVIAT (APP amino acids 709-714) under UAS control. Construct uses the human APP signal sequence, and 3 copies of the HA tag at the C-terminus.
APP/C99 - mutant P{UAS-APP.C99.YIPLFL.HA.Exel}3 33787 Expresses the C99 fragment of APP with amino acids YIPLFL substituted for GVVIAT (APP amino acids 709-714) under UAS control. Construct uses the human APP signal sequence and has 3 copies of the HA tag at the C-terminus.
      Stocks carrying the Abeta42 fragment of human APP
Abeta42 P{UAS-APP.Abeta42.B}m26a 33770 Expresses the human Abeta42 fragment of APP under the control of UAS. Stock also expresses GFP under actin control in males.
Abeta42 P{UAS-APP.Abeta42.B}m26a 33769 Expresses the human Abeta42 fragment of APP under the control of UAS.
Abeta42 P{UAS-Abeta1-42.G}3 32037 Expresses the 42 amino acid version of human Abeta under the control of UAS.
Abeta42 P{UAS-Abeta1-42.G}1 32038 Expresses the 42 amino acid version of human Abeta under the control of UAS.
Abeta42 - Arctic P{UAS-APP.Abeta42.E693G.VTR}8 33774 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Arctic' mutation (E693G - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Arctic P{UAS-APP.Abeta42.E693G.VTR}4 33773 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Arctic' mutation (E693G - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Dutch P{UAS-APP.Abeta42.E693Q.VTR}3 33776 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Dutch' mutation (E693Q - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Dutch P{UAS-APP.Abeta42.E693Q.VTR}2 33775 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Dutch' mutation (E693Q - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Flemish P{UAS-APP.Abeta42.A692G.VTR}6 33777 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Flemish' mutation (A692G - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Flemish P{UAS-APP.Abeta42.A692G.VTR}2 33778 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Flemish' mutation (A692G - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Iowa P{UAS-APP.Abeta42.D694N.VTR}X 35584 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Iowa' mutation (D694N - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Iowa P{UAS-APP.Abeta42.D694N.VTR}3 33780 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Iowa' mutation (D694N - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Iowa P{UAS-APP.Abeta42.D694N.VTR}2 33779 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Iowa' mutation (D694N - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Italian P{UAS-APP.Abeta42.E693K.VTR}8 33781 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Italian' mutation (E693K - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 - Italian P{UAS-APP.Abeta42.E693K.VTR}12 33782 Expresses the human Abeta42 fragment of APP carrying the familial Alzheimer's 'Italian' mutation (E693K - amino acid numbering based on APP sequence) under the control of UAS.
Abeta42 and tau P{UAS-Abeta42.B}m26a, P{UAS-MAPT.VTR}12D 33772 Expresses the human Abeta42 fragment of APP and human MAPT (tau) under the control of UAS. Also expresses hid under heatshock control only in males.
Abeta42 and tau P{UAS-Abeta42.B}m26a, P{UAS-MAPT.VTR}12D 33771 Expresses the human Abeta42 fragment of APP and human MAPT (tau) under the control of UAS. Stock also expresses GFP under actin control only in males and hid under heatshock control only in females.
      Stocks carrying human APP-like proteins, APLP1 and APLP2
APP/APLP2 P{UAS-HsapAPLP2::HsapAPP.T:Myc}2 30123 Expresses a myc-tagged fusion of human APP and APLP2 under UAS control.
      Fly APP-like (Appl) stocks
Appl Appl[d] 43632 Null allele of Appl (deletion of the central part of the gene)
Appl - RNAi P{TRiP.JF02878}attP2 28043 Expresses double-stranded RNA for RNAi of Appl under the control of UAS.
Appl - RNAi P{TRiP.HMS01931}attP40 39013 Expresses dsRNA for RNAi of Appl (FBgn0000108) under UAS control.
Appl P{UAS-Appl.V5}3 63222 Expresses a V5-tagged APPL under the control of UAS.
Appl P{UAS-Appl.V5}1 63223 Expresses a V5-tagged APPL under the control of UAS.
Appl P{UAS-Appl.T}2 38403 Expresses full-length Appl under the control of UAS.
Appl P{UAS-Appl.sdDeltaCg}KW 32041 Expresses a constitutively membrane-bound form of Appl deleted for the Go binding domain (amino acids 845-855) under the control of UAS.
Appl - ECD mtuant P{UAS-Appl.sdDeltaE1}3 29866 UAS sequences control expression of a constitutively membrane-bound form of Appl deleted for a region (amino acids 85-321) of the extracellular domain including part of the E1 domain.
Appl - ECD mutant P{UAS-Appl.sdDeltaE2}3 29867 UAS sequences control expression of a constitutively membrane-bound form of Appl deleted for a region (amino acids 449-740) of the extracellular domain including most of the E2 domain.
Appl - ICD mutant P{UAS-Appl.sdDeltaIC}2 29865 UAS sequences control expression of a constitutively membrane-bound form of Appl deleted for the intracellular domain.
Appl - mutant P{UAS-Appl.sd}2 29863 UAS sequences control Appl deleted for a cleavage site resulting in a constitutively membrane-bound protein.
Appl - NPTY mutant P{UAS-Appl.sdDeltaNPTY}3 29864 UAS sequences control expression of a constitutively membrane-bound form of Appl deleted for the NPTY internalization sequence.
Appl - secreted P{UAS-Appl.s}2 29862 Expresses a secreted form of Appl under the control of UAS.
Appl P{Appl-GAL4.G1a}1 32040 Expresses GAL4 in the larval nervous system under the control of APPL.
Appl Mi{Trojan-GAL4.0}Appl[MI11551-TG4.0] 66900 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of Appl regulatory sequences.
      Stocks carrying human BACE1
BACE1 (human) P{UAS-BACE1.VTR}A 33804 Expresses human BACE1 under UAS control.
BACE1 (human) P{UAS-BACE1.L}2 29877 Expresses human BACE (beta-secretase) under the control of UAS.
      Stocks carrying human FE65/APBB1
Fe65 (aka APBB1) P{UAS-HsapAPBB1-HA}3 29882 UAS sequences control expression of human APBB1 (aka Fe65) tagged with HA.
Fe65 (aka APBB1) P{UAS-HsapAPBB1-HA}2 29881 UAS sequences control expression of human APBB1 (aka Fe65) tagged with HA.
      Stocks carrying human HSD17B10 and Fly scu stocks
ERAB (aka HSD17B10) P{UAS-HSD17B10.Exel}1 33806 Expresses human HSD17B10 (ERAB) under UAS control. May be segregating CyO.
      Fly par-1 stocks
par-1 par-1[k05603] 10574 P{lacW} insertion into the 5' UTR of par-1 and mei-W68
par-1 Mi{MIC}par-1[MI07146] 55433 This Mi{MIC} insertion in an intron of par-1 is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
par-1 P{TRiP.HMS00405}attP2 32410 Expresses dsRNA for RNAi of par-1 (FBgn0260934) under the control of UAS.
par-1 P{TRiP.GL00253}attP2 35342 Expresses dsRNA for RNAi of par-1 (FBgn0260934) under the control of UAS.
par-1 Mi{PT-GFSTF.2}par-1[MI12277-GFSTF.2] 64452 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of par-1 tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
par-1 P{lacW}par-1[k06323] 10615 P{lacW} insertion in the 5' UTR or second intron par-1 (depending on the transcript)
      Fly nicastrin (nct) stocks
nct nct[J1] 63240 Amino acid change results in a loss of function allele
nct nct[E3] 63241 Hypomorphic allele of nct
nct nct[A7] 41781 An allele of nct caused by aa change Q640stop.
nct P{TRiP.JF02648}attP2 27498 Expresses double-stranded RNA for RNAi of nicastrin under the control of UAS
nct P{TRiP.HMC04812}attP40 57497 Expresses dsRNA for RNAi of nct (FBgn0039234) under UAS control.
nct P{UAS-nct.2.myc}3 63215 Expresses myc-tagged nct under the control of UAS.
      Fly pen-2 stocks
pen-2 P{TRiP.JF02608}attP2 27298 Expresses double-stranded RNA for RNAi of pen-2 under the control of UAS
pen-2 P{TRiP.HMC03648}attP40 52908 Expresses dsRNA for RNAi of pen-2 (FBgn0053198) under UAS control.
pen-2 P{UAS-pen-2.flag}3 64067 Expresses FLAG-tagged pen-2 under the control of UAS.
pen-2 P{UAS-pen-2.flag}2 63219 Expresses FLAG-tagged pen-2 under the control of UAS.
pen-2 P{UAS-pen-2.flag}1 63218 Expresses FLAG-tagged pen-2 under the control of UAS.
      Stocks carrying human PSEN1 and PSEN2
PSEN1 P{UAS-PSEN1.VTR}11 33811 Expresses human Presenilin 1 (PSEN1) isoform I-467 under the control of UAS.
PSEN1 P{UAS-PSEN1.VTR}1 33812 Expresses human Presenilin 1 (PSEN1) isoform I-467 under the control of UAS.
PSEN1 - M146V P{UAS-PSEN1.M146V.Exel}4 33813 Expresses human Presenilin 1 (PSEN1) carrying the familial Alzheimer's mutation M146V under the control of UAS.
PSEN1 - P267S P{UAS-PSEN1.P267S.Exel}1 33814 Expresses human Presenilin 1 (PSEN1) carrying the familial Alzheimer's mutation P267S under the control of UAS.
PSEN2 P{UAS-PSEN2.Exel}7b 33817 Expresses human Presenilin 2 (PSEN2) under the control of UAS.
PSEN2 - M239V P{UAS-PSEN2.M239V.Exel}2b 33815 Expresses human Presenilin 2 (PSEN2) carrying the familial Alzheimer's mutation M239V under the control of UAS.
PSEN2 - N141I P{UAS-PSEN2.N141I.Exel}8b 33816 Expresses human Presenilin 2 (PSEN2) carrying the familial Alzheimer's mutation N141I under the control of UAS.
      Fly Psn stocks
Psn lof Psn[143] 8296 Presenilin null allele on a FRT-bearing chromosome for making clones.
Psn lof Psn[143] 8297 Presenilin null allele
Psn Psn[C4] 63238 Amino acid change W152stop. Mutation is predicted to result in a truncated protein ending at the beginning of the second transmembrane domain.
Psn Psn[B3] 63239 Amino acid change G516E results in a loss of function allele
Psn lof Psn[9] 8295 Presenilin hypomorphic allele
Psn Psn[V1] 63237 Amino acid change W478stop. Mutation is predicted to result in a truncated protein ending at the beginning of the eighth transmembrane domain.
Psn - RNAi P{UAS-antisense.Psn.541}3 8316 Expresses the sequence for the 541 amino acid isoform of Psn in the antisense direction under the control of UAS.
Psn - RNAi P{UAS-antisense.Psn.541}2 8317 Expresses the sequence for the 541 amino acid isoform of Psn in the antisense direction under the control of UAS.
Psn - RNAi P{UAS-antisense.Psn.541}1 8318 Expresses the sequence for the 541 amino acid isoform of Psn in the antisense direction under the control of UAS.
Psn - RNAi P{TRiP.JF02760}attP2 27681 Expresses double-stranded RNA for RNAi of Psn under the control of UAS.
Psn - RNAi P{TRiP.HMS01843}attP40 38374 Expresses dsRNA for RNAi of Psn (FBgn0019947) under the control of UAS.
Psn P{UAS-Psn.N.myc}3 64046 Expresses Psn with an N-terminal myc-tag under the control of UAS. The tag detects both the intact holoprotein and the processed N-terminal fragment.
Psn P{UAS-Psn.N.myc}2 63212 Expresses Psn with an N-terminal myc-tag under the control of UAS. The tag detects both the intact holoprotein and the processed N-terminal fragment.
Psn P{UAS-Psn.loop.myc}3 63211 Expresses Psn with a myc-tag inserted in the cytoplasmic loop expressed under the control of UAS. The tag detects both the intact holoprotein and the processed C-terminal fragment.
Psn P{UAS-Psn.loop.myc}2 63210 Expresses Psn with a myc-tag inserted in the cytoplasmic loop expressed under the control of UAS. The tag detects both the intact holoprotein and the processed C-terminal fragment.
Psn P{UAS-Psn.541.Exel}3 8310 Expresses the wild type 541 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.541.Exel}2 8309 Expresses the wild type 541 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.541.Exel}1 8308 Expresses the wild type 541 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.527.Exel}3 8306 Expresses the wild type 527 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.527.Exel}2 8305 Expresses the wild type 527 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.527.Exel}1 8304 Expresses the wild type 527 amino acid isoform of Psn under the control of UAS.
Psn P{UAS-Psn.-14}3 63214 Expresses the short form (cytoplasmic loop is 14 aa shorter than in the 'long' form) of Psn under the control of UAS.
Psn P{UAS-Psn.+14}3 63213 Expresses the long form (cytoplasmic loop is 14 aa longer than in the 'short' form) of Psn under the control of UAS.
Psn P{UAS-Psn.+14}2 63243 Expresses the long form (cytoplasmic loop is 14 aa longer than in the 'short' form) of Psn under the control of UAS.
Psn P{sev-Psn.527.Exel}3 8314 Expresses the wild type 527 amino acid isoform of Psn in the eye.
Psn P{sev-Psn.527.Exel}2 8315 Expresses the wild type 527 amino acid isoform of Psn in the eye.
Psn P{Psn.N.myc}3 63209 Expresses Psn with an N-terminal myc-tag under the control of a Psn promoter. The tag detects both the intact holoprotein and the processed N-terminal fragment.
Psn P{Psn.loop.myc}32 63207 Expresses Psn with a myc-tag inserted in the cytoplasmic loop expressed under the control of a Psn promoter. The tag detects both the intact holoprotein and the processed C-terminal fragment.
Psn P{Psn.loop.myc}3 63208 Expresses Psn with a myc-tag inserted in the cytoplasmic loop expressed under the control of a Psn promoter. The tag detects both the intact holoprotein and the processed C-terminal fragment.
Psn P{GMR-Psn.527.Exel}3 8319 Expresses the wild type 527 amino acid isoform of Psn in the eye.
Psn P{GMR-Psn.527.Exel}2 8320 Expresses the wild type 527 amino acid isoform of Psn in the eye.
Psn - D279A (D257A) P{GMR-Psn.527.D279A}3 8332 Expresses the 527 amino acid isoform of Psn with a D279A amino acid change in the eye. D279A mimics the D257A change in humans.
Psn - D279A (D257A) P{GMR-Psn.527.D279A}2 8333 Expresses the 527 amino acid isoform of Psn with a D279A amino acid change in the eye. D279A mimics the D257A change in humans.
Psn - D447A (D385A) P{UAS-Psn.527.D447A}3 8323 Expresses the 541 amino acid isoform of Psn with a D447A amino acid change under the control of UAS. D447A mimics the D385A change in humans.
Psn - D447A (D385A) P{UAS-Psn.527.D447A}2 8322 Expresses the 541 amino acid isoform of Psn with a D447A amino acid change under the control of UAS. D447A mimics the D385A change in humans.
Psn - D447A (D385A) P{UAS-Psn.527.D447A}1 8321 Expresses the 541 amino acid isoform of Psn with a D447A amino acid change under the control of UAS. D447A mimics the D385A change in humans.
Psn - D447A (D385A) P{GMR-Psn.527.D447A}3 8335 Expresses the 527 amino acid isoform of Psn with a D279A amino acid change in the eye. D279A mimics the D257A change in humans.
Psn - D447A (D385A) P{GMR-Psn.527.D447A}2 8334 Expresses the 527 amino acid isoform of Psn with a D279A amino acid change in the eye. D279A mimics the D257A change in humans.
Psn - D447A (D385A) P{GMR-Psn.527.D447A}1 8336 Expresses the 527 amino acid isoform of Psn with a D279A amino acid change in the eye. D279A mimics the D257A change in humans.
Psn - D477A/exon9 P{UAS-Psn.527.deltaE9.D447A}3 8328 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys and a D447A amino acid change under UAS control. D447A mimics the D385A change in humans.
Psn - D477A/exon9 P{UAS-Psn.527.deltaE9.D447A}2 8327 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys and a D447A amino acid change under UAS control. D447A mimics the D385A change in humans.
Psn - D477A/exon9 P{UAS-Psn.527.deltaE9.D447A}1 8329 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys and a D447A amino acid change under UAS control. D447A mimics the D385A change in humans.
Psn - D477A/exon9 P{GMR-Psn.527.deltaE9.D447A}2 8330 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys and a D447A amino acid change in the eye. D447A mimics the D385A change in humans.
Psn - D477A/exon9 P{GMR-Psn.527.deltaE9.D447A}1 8331 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys and a D447A amino acid change in the eye. D447A mimics the D385A change in humans.
Psn - M255V (M239V) P{UAS-Psn.541.M255V}3 8313 Expresses the 541 amino acid isoform of Psn with a M255V amino acid change under the control of UAS. M255V mimics the M239V change in humans.
Psn - M255V (M239V) P{UAS-Psn.541.M255V}2 8312 Expresses the 541 amino acid isoform of Psn with a M255V amino acid change under the control of UAS. M255V mimics the M239V change in humans.
Psn - M255V (M239V) P{UAS-Psn.541.M255V}1 8311 Expresses the 541 amino acid isoform of Psn with a M255V amino acid change under the control of UAS. M255V mimics the M239V change in humans.
Psn - N157I (N141I) P{UAS-Psn.541.N157I.Exel}3 8584 Expresses the 541 amino acid isoform of Psn with a N157I amino acid change under the control of UAS. N157I mimics the N141I change in humans.
Psn - N157I (N141I) P{UAS-Psn.541.N157I.Exel}1 8307 Expresses the 541 amino acid isoform of Psn with a N157I amino acid change under the control of UAS. N157I mimics the N141I change in humans.
Psn - exon9 mutant P{UAS-Psn.527.deltaE9}3 8337 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys under UAS control.
Psn - exon9 mutant P{UAS-Psn.527.deltaE9}2 8338 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys under UAS control.
Psn - exon9 mutant P{GMR-Psn.527.deltaE9}3 8326 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys in the eye.
Psn - exon9 mutant P{GMR-Psn.527.deltaE9}2 8325 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys in the eye.
Psn - exon9 mutant P{GMR-Psn.527.deltaE9}1 8324 Expresses the 527 amino acid isoform of Psn with the equivalent of human Psn exon 9 deleted and replaced with a Cys in the eye.
      Stocks carrying human Tau (MAPT) and fly tau stocks
tau tau[MR22] 9530 An imprecise excision of P{EP}tau[EP3203] has deleted 62 kb removing almost all of the tau gene including the microtubule binding domain. The mini-white of the P{EP} is still present.
tau TI{TI}tau[KO] 64782 Homologous replacement of tau exons with miniwhite.
tau P{TRiP.HMS02042}attP40 40875 Expresses dsRNA for RNAi of tau (FBgn0051057) under UAS control.
tau P{TRiP.HM05101}attP2 28891 Expresses double-stranded RNA for RNAi of tau under the control of UAS.
tau Mi{PT-GFSTF.0}tau[MI03440-GFSTF.0] 60199 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of tau tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
tau (human) P{UAS-Tau.wt}7B 51363 Expresses the 2N4R isoform of human tau (MAPT) under the control of UAS.
tau (human) P{UAS-Tau.wt}1.13 51362 Expresses the 2N4R isoform of human tau (MAPT) under the control of UAS.
tau (human) P{UAS-MAPT.VTR}12D 33819 Expresses human MAPT (tau) under the control of UAS.
tau (human) P{UAS-MAPT.B}31o 33820 Expresses human MAPT (tau) under the control of UAS.
tau (human) P{UAS-MAPT.A}59A 181 Expresses human Microtubule-associated protein tau under the control of UAS.
tau (human) P{UAS-hMAPT.Z}attP40 64388 Expresses human MAPT under UAS control.
tau (human) P{UAS-hMAPT.HA}attP40 64389 Expresses human MAPT protein with a C-terminal HA tag under UAS control.
tau (human) P{GMR-MAPT.EGFP.J}2 51368 Expresses the 2N4R isoform of human tau (MAPT with EGFP fused to the C term under the control of GMR in the eye.
tau (human) P{GMR-htau.Ex}3 51361 Expresses the 2N4R isoform of human tau (MAPT) in the eye under the control of GMR.
tau (human) P{GMR-htau.Ex}1.1 51373 Expresses the 2N4R isoform of human tau (MAPT) in the eye under the control of GMR.
tau (human) P{GMR-htau.Ex}1.1 51360 Expresses the 2N4R isoform of human tau (MAPT) in the eye under the control of GMR.
tau (MAPT, bovine) P{Mhc-tauGFP}2 38460 Expresses GFP-tagged tau under the control of Mhc.
tau (MAPT, bovine) P{Mhc-tauGFP}1 53736 Expresses GFP-tagged tau under the control of Mhc.
tau (MAPT, bovine) P{Mhc-tauGFP}1 53739 Expresses GFP-tagged tau under the control of Mhc.
tau P{EP}tau[G4714] 63271 This P{EP} insertion in the non-coding first exon of tau is uncharacterized but is oriented such that it may overexpress tau in the presence of GAL4.
tau (human) P{UAS-Tau.S2A}1.62 51365 Expresses the 2N4R isoform of human tau (MAPT) with mutations at two sites, S262A and S356A (PAR-1 phosphorylation sites), under the control of UAS.
tau (human) P{UAS-Tau.S2A}1.33 51364 Expresses the 2N4R isoform of human tau (MAPT) with mutations at two sites, S262A and S356A (PAR-1 phosphorylation sites), under the control of UAS.
tau (human) P{UAS-Tau.S11A}1.2 51366 Expresses the 2N4R isoform of human tau (MAPT) with Ser to Ala changes at 11 sgg-phosphorylated residues (S46A, T50A, S199A, T202A, T205A, T212A, S214A, T231A, S235A, S396A and S404A) under the control of UAS.
tau (human) P{GMR-MAPT.V337M}2 51369 Expresses the 2N4R isoform of human tau (MAPT) with a V337M change under the control of GMR in the eye.
tau (human) P{GMR-MAPT.V337M}10 51367 Expresses the 2N4R isoform of human tau (MAPT) with a V337M change under the control of GMR in the eye.
tau (human) P{GMR-htau.P301L}x 51377 Expresses human tau (MAPT) with a P301L change under the control of GMR in the eye.
      Stocks carrying multiple constructs
Abeta42 and tau P{UAS-Abeta42.B}m26a, P{UAS-MAPT.VTR}12D 33771 Expresses the human Abeta42 fragment of APP and human MAPT (tau) under the control of UAS. Stock also expresses GFP under actin control only in males and hid under heatshock control only in females.
Abeta42 and tau P{UAS-Abeta42.B}m26a, P{UAS-MAPT.VTR}12D 33772 Expresses the human Abeta42 fragment of APP and human MAPT (tau) under the control of UAS. Also expresses hid under heatshock control only in males.
APP and BACE1 P{UAS-BACE1.Exel}7b, P{UAS-APP.695.Exel}1 33797 Expresses human BACE1 and the 695 amino acid isoform of human APP under the control of UAS. Homozygotes may be present.
APP and BACE1 P{UAS-APP695-N-myc}TW6, P{UAS-BACE1.Exel}1b 33798 Expresses human BACE1 and an N-terminally myc-tagged 695 amino acid isoform of human APP under the control of UAS.
APP and tau P{UAS-APP.C99.myc.Exel}21, P{UAS-MAPT.VTR}31K 33803 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag and human MAPT (tau) under UAS control.
APP and tau P{UAS-APP.C99.myc.Exel}19, P{UAS-MAPT.VTR}12B 33801 Expresses the C99 fragment of APP with the human APP signal peptide and a C-terminal myc tag and human MAPT (tau) under UAS control.
APP and tau P{UAS-APP.695.Exel}3, P{UAS-MAPT.VTR}31K 33802 Expresses human MAPT (tau) and the 695 amino acid isoform of human APP under the control of UAS, VTR.
APP, BACE1 and tau P{UAS-MAPT.VTR}54, P{UAS-APP.695.Exel}3, P{UAS-BACE1.Exel}9a 33799 Expresses human MAPT (tau), human BACE1, and the 695 amino acid isoform of human APP under the control of UAS.
APP, BACE1 and tau P{UAS-APP.695.Exel}3, P{UAS-BACE1.Exel}9a, P{UAS-MAPT.VTR}31 33800 Expresses human MAPT (tau), human BACE1, and the 695 amino acid isoform of human APP under the control of UAS.