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Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) is a progressive neurodegenerative disease associated with degeneration of motor neurons resulting in muscle weakness and atrophy. Fly stocks in the Bloomington collection that can be used to study ALS are listed here.

For stocks to study the expanded GGGGCC repeats in C9orf72, see the page for Frontotemporal dementia and/or Amyotrophic lateral sclerosis.

General information links for ALS:
OMIM links for individual subtypes are provided in the table below
NLM/NIH's Genetics Home Reference - includes links to GHR pages for several of the genes
NIH's Genetic and Rare Disease Information Center
ALS subtypes with causative genes identified (from OMIM)
Subtype Human gene Human protein Fly gene
ALS1 SOD1 SOD1 (superoxide dismutase 1) Superoxide dismutase (Sod)
ALS2 ALS2 Alsin Als2
ALS4 SETX senataxin  
ALS6 FUS FUS cabeza (caz)
ALS8 VAPB VAMP-associated protein B (VAPB) Vap-33A
ALS9 ANG Angiogenin  
ALS10 TARDBP Tar DNA-binding protein (TARDBP) TBPH
ALS11 FIG4 FIG4/SAC3 CG17840
ALS12 OPTN Optineurin  
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
ALS1      Human SOD1       Fly Sod
Sod1 Sod1[F] 7451 Stock contains Sod[n64] (a Sod amorph, G42E) and Sod[F] (an electrophoretic variant of Sod).
Sod1 Sod1[X-39] 24490 A 395 bp deletion takes out transcription start and first exon
Sod1 Sod1[n64] 7451 Stock contains Sod[n64] (a Sod amorph, G42E) and Sod[F] (an electrophoretic variant of Sod).
Sod1 Sod1[n1] 24492 Sod loss of function mutation (G49S)
Sod1 P{UAS-Sod1.IR}F103 24493 Expresses dsRNA for RNAi of Sod.
Sod1 P{UAS-Sod1.IR}4 24491 Expresses dsRNA for RNAi of Sod.
Sod1 P{TRiP.JF03321}attP2 29389 Expresses dsRNA for RNAi of Sod.
Sod1 P{TRiP.HMS01291}attP2 34616 Expresses dsRNA for RNAi of Sod (FBgn0003462) under the control of UAS.
Sod1 P{TRiP.HMS00698}attP2 32909 Expresses dsRNA for RNAi of Sod (FBgn0003462) under the control of UAS.
Sod1 P{TRiP.GL01016}attP40 36804 Expresses dsRNA for RNAi of Sod (FBgn0003462) under the control of UAS.
Sod1 P{UAS-Sod1}12.1 33605 Expresses Sod under UAS control.
Sod1 P{UAS-Sod1.A}B37 24750 Expresses Sod under UAS control.
Sod1 P{UAS-Sod1.A}B36 24754 Expresses Sod under UAS control.
Sod1 Mi{Trojan-GAL4.0}Sod1[MI08143-TG4.0] 66807 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of Sod1 regulatory sequences.
SOD1 (human) P{UAS-hSOD1}16.2 33606 Expresses human Sod1 under the control of UAS.
SOD1 (human) P{UAS-hSOD1.Z}attP40 64386 Expresses human SOD1 under UAS control.
SOD1 (human) P{UAS-hSOD1.HA}attP40 64387 Expresses human SOD1 protein with a C-terminal HA tag under UAS control.
SOD1 (human) M{UAS-hSOD1.HA.J}ZH-86Fb 66015 Expresses human SOD1 under UAS control.
SOD1 (human) P{UAS-hSOD1.G85R} (4 copies) 33608 Expresses human Sod1 with amino acid change G85R (a familial Amyotrophic lateral sclerosis mutation) under the control of UAS.
SOD1 (human) P{UAS-hSOD1.A4V}9.1 33607 Expresses human Sod1 with amino acid change A4V (a familial Amyotrophic lateral sclerosis mutation) under the control of UAS.
ALS2      Human Alsin       Fly Als2
Als2 P{TRiP.HM05019}attP2 28533 Expresses dsRNA for RNAi of CG7158 under UAS control.
Als2 P{EP}Als2[G4607] 27162 This P{EP} insertion in the 5' UTR is uncharacterized but is oriented such that the UAS in the insert could overexpress CG7158 in the presence of GAL4.
ALS6      Human FUS       Fly caz
caz caz[8b] 67698 EMS-induced recessive lethal mutation in caz.
caz caz[5g11] 67699 Recessive lethal mutation in caz (likely EMS-induced).
caz P{TRiP.HMS00790}attP2 32990 Expresses dsRNA for RNAi of caz (FBgn0011571) under the control of UAS.
caz P{TRiP.HMS00156}attP2 34839 Expresses dsRNA for RNAi of caz (FBgn0011571) under the control of UAS.
caz P{caz[+t5]}3 68450 Genomic rescue construct for caz.
caz P{EP}caz[EP1564] 17010 This P{EP} inserted upstream of caz is uncharacterized but is oriented such that it could cause expression of caz in the presence of GAL4.
ALS8      Human VAPB      Fly Vap-33A
Vap33 Vap33[Delta448] 39683 Imprecise excision of a P{lArB} that deletes all the Vap-33-1 coding sequence.
Vap33 Vap33[Delta20] 39684 Imprecise excision of a P{lArB} that deletes all the Vap-33-1 coding sequence.
Vap33 P{lacW}Vap33[G0231] 12233 This P{lacW} insertion in the third exon is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Vap33 P{TRiP.JF02621}attP2 27312 Expresses dsRNA for RNAi of Vap-33-1 under UAS control.
Vap33 P{UAS-Vap-33-1.P}3 26693 Expresses Vap-33-1 under the control of UAS.
Vap33 P{UAS-FLAG.Vap-33-1.HA}2 39682 Expresses Vap-33-1 with FLAG and HA tags under the control of UAS
ALS10      Human TARDBP      Fly TBPH
TBPH P{TRiP.HMS01932}attP40 39014 Expresses dsRNA for RNAi of TBPH (FBgn0025790) under UAS control.
TBPH P{TRiP.HM05194}attP2 29517 Expresses dsRNA for RNAi of TBPH under UAS control.
TARDBP (human, aka TDP-43) P{UAS-TARDBP.J}6M 51371 Expresses insect codon-optimized TARDBP (aka TDP-43) under the control of UAS.
TARDBP (human, aka TDP-43) P{UAS-TARDBP.J}3 51372 Expresses insect codon-optimized TARDBP (aka TDP-43) under the control of UAS.
TARDBP (human, aka TDP-43) P{GMR-TARDBP.J}3-4 51370 Expresses insect codon-optimized TARDBP (aka TDP-43) under the control of GMR in the eye.
ALS11      Human FIG4/SAC3       Fly CG17840
FIG4 P{TRiP.HMS01749}attP40 38291 Expresses dsRNA for RNAi of CG17840 (FBgn0031611) under the control of UAS.
FIG4 P{TRiP.HMJ21919}attP40 58063 Expresses dsRNA for RNAi of CG17840 (FBgn0031611) under UAS control.