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Fragile X Syndrome
Fragile X syndrome is the most common form of inherited intellectual disability. Disease severity can vary but all forms seem to be caused by expansion of a CGG repeat in the 5' untranslated region of the FMR1 gene that silences the gene. Fly stocks in the Bloomington collection that can be used to study Fragile X Syndrome are listed here.

General information links for Fragile X syndrome:
OMIM
NIH's Genetics Home Reference - includes links for GHR pages on FMR1
NLM/NIH's Genetic and Rare Disease Information Center
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human fragile X mental retardation 1 (FMR1)       Fly Fmr1
Fmr1 Fmr1[Delta50M] 6930 Fmr1 null allele (deletion of 5' non-coding exons plus first coding exon)
Fmr1 Fmr1[Delta113M] 67403 Fmr1 null allele (deletion of 5' non-coding exons plus first two coding exons)
Fmr1 Df(3R)Exel6265 7732 Fmr1 deletion
Fmr1 P{EP}Fmr1[EP3517] 6928 This insertion of a P{EP} in noncoding exon 1 results in a hypomorphic allele.
Fmr1 Mi{MIC}Fmr1[MI09043] 52135 This intronic Mi{MIC} insertion is uncharacterized but is an unverified lethal suggesting it may disrupt function.
Fmr1 P{TRiP.JF02634}attP2 27484 Expresses double-stranded RNA for RNAi of Fmr1.
Fmr1 P{TRiP.HMS00248}attP2 34944 Expresses dsRNA for RNAi of Fmr1 (FBgn0028734) under the control of UAS.
Fmr1 P{TRiP.GL00075}attP2 35200 Expresses dsRNA for RNAi of Fmr1 (FBgn0028734) under the control of UAS.
Fmr1 P{UAS-Fmr1.Z}3 6931 Expresses Fmr1 under the control of UAS.