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Galactosemia is caused by an inability to metabolize galactose. It usually manifests during early infancy and can be life-threatening if not treated immediately. Long-term complications include cataracts, speech problems, developmental delays,intellectual disabilities and reproductive (ovarian) issues. Fly stocks in the Bloomington collection that can be used to study Galactosemia are listed here.

General information links for Galactosemia:
OMIM links to each form of Galactosemia are listed in the table below
NIH's Genetics Home Reference
NLM/NIH's Genetic and Rare Disease Information Center
Galactosemia subtypes (from OMIM)
subtype Human gene symbol Human gene full name Fly gene
Galactosemia, Type 1 (classic) GALT Galactose-1-phosphate uridylyltransferase Galt
Galactokinase deficiency (Galactosemia, Type II) GALK1 Galactokinase Galk
Galactose epimerase deficiency (Galactosemia, Type III) GALE UDP-galactose-4-prime-epimerase Gale
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
fly Gale       Human GALE
Gale Gale[h] 37739 Gale hypomorphic allele caused by an imprecise excision of P{EPgy2}Gale[EY22205]. This allele is weaker than Gale[Deltay].
Gale Gale[Deltay] 37738 Gale loss of function allele caused by an imprecise excision of P{EPgy2}Gale[EY22205] that results in 1339 deletion including the first coding exon.
Gale P{TRiP.HMC02429}attP2 44496 Expresses dsRNA for RNAi of Gale (FBgn0035147) under UAS control.
GALE (human) P{UAS-hGALE.S}32A 37740 Expresses human GALE under the control of UAS.
fly Galk
Galk Mi{ET1}Galk[MB10014] 27825 This Mi{ET1} insertion in the 5' untranslated region is uncharacterized but is an unverified lethal (suggesting it may disrupt function). 7/31/12
Galk P{TRiP.HMC05085}attP40 60091 Expresses dsRNA for RNAi of Galk (FBgn0263199) under UAS control.
Galk P{TRiP.GL00268}attP2 35356 Expresses dsRNA for RNAi of Galk (FBgn0263199) under the control of UAS.