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Hereditary spastic paraplegias
Hereditary spastic paraplegias (SPGs) are a group of neurodegenerative disorders associated with degeneration of corticospinal axons and generally characterized by progressive spasticity in the lower extremities. Fly stocks in the Bloomington collection that can be used to study hereditary spastic paraplegias are listed here.

General information links for Hereditary spastic paraplegia:
OMIM links for individual subtypes are provided in the table below
NLM/NIH's Genetics Home Reference - contains links to GHR pages for several of the subtypes
NIH's Genetics and Rare Disease Information Center
SPG subtypes with causative genes identified (from OMIM)
SPG subtype Human gene Human protein Fly gene
SPG1/L1 or MASA syndrome L1CAM L1CAM Neuroglian (Nrg)
SPG2 PLP1 PLP1 and DM20 M6
SPG3A/Strumpell disease SPG3A atlastin atlastin (atl)
SPG4 SPG4 spastin spastin (spas)
SPG5A CYP7B1 CYP7B1  
SPG6 NIPA1 NIPA1 spichthycin (spict)
SPG7 SPG7 paraplegin CG2658
SPG8 KIAA0196 strumpellin CG12272
SPG10 KIF5A KIF5A Kinesin heavy chain (Khc)
SPG11 SPG11 spatacsin CG13531
SPG13 HSPD1 Hsp60 Hsp60
SPG15 ZFYVE26 spastizin CG5270
SPG17/Silver syndrome BSCL2 seipin Seipin
SPG20/Troyer syndrome SPG20 spartin spartin
SPG21/Mast syndrome ACP33 maspardin/ACP33  
SPG31 REEP1 REEP1 CG42678
SPG33 ZFYVE27 ZFYVE27  
SPG42 SLC33A1 AT1/SLC33A1 CG9706
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
SPG1      Human LICAM       Fly Nrg
Nrg Nrg[l7] 5595 Nrg loss of function mutation (W80stop)
Nrg Nrg[l4] 5708 loss of function mutation in Nrg
Nrg Nrg[849] 35827 loss of function allele of Nrg caused by aa change S213L
Nrg P{lacW}Nrg[G0488b] 12275 This P{lacW} insertion in the 3rd intron results in disruption of Nrg.
Nrg P{lacW}Nrg[G0413] 12252 This P{lacW} insertion in the 4th exon (a coding exon) results in disruption of Nrg.
Nrg P{lacW}Nrg[G0099] 11814 This P{lacW} insertion in the 1st exon or intron (depending on the transcript) results in disruption of Nrg.
Nrg Nrg[l10] 24167 temperature-sensitive mutation in Nrg
Nrg P{TRiP.JF03151}attP2 28724 Expresses dsRNA for RNAi of Nrg under UAS control.
Nrg P{TRiP.HMS01638}attP40 37496 Expresses dsRNA for RNAi of Nrg (FBgn0002968) under the control of UAS.
Nrg P{TRiP.GL00656}attP40 38215 Expresses dsRNA for RNAi of Nrg (FBgn0002968) under the control of UAS.
Nrg P{PTT-GA}Nrg[G00305] 6844 A GFP trap inserted in an Nrg intron. Expresses GFP-tagged Neuroglian.
Nrg P{UAS-nrg[180]}30b 24170 Expresses the 180 kDa neuronal-specific isoform of Nrg under the control of UAS.
Nrg P{UAS-nrg[180]}28b 24169 Expresses the 180 kDa neuronal-specific isoform of Nrg under the control of UAS.
Nrg P{UAS-nrg[167]}2 24172 Expresses the 167 kDa isoform of Nrg under the control of UAS.
Nrg P{UAS-Nrg.GPI}2 24168 Expresses an artificial GPI-anchored Nrg under the control of UAS.
SPG2      Human PLP1       Fly M6
M6 P{EPgy2}M6[EY07032] 16780 This P{EPgy2} insertion in the 1st exon (noncoding) results in a hypomoprhic allele.
M6 Mi{ET1}M6[MB02608] 24023 This Mi{ET1} insertion in the last exon in coding sequence results in loss or reduction of function.
M6 P{TRiP.HMS01645}attP40 37503 Expresses dsRNA for RNAi of M6 (FBgn0037092) under the control of UAS.
M6 P{TRiP.HMJ21475}attP40 54032 Expresses dsRNA for RNAi of M6 (FBgn0037092) under UAS control.
SPG3      Human atlastin       Fly atl
atl P{TRiP.HMS01627}attP40 36736 Expresses dsRNA for RNAi of atl (FBgn0039213) under the control of UAS.
SPG4      Human SPG4/spastin       Fly spas
spas P{TRiP.JF02724}attP2 27570 Expresses dsRNA for RNAi of spas under UAS control
spas P{TRiP.HMC03560}attP40 53331 Expresses dsRNA for RNAi of spas (FBgn0039141) under UAS control.
SPG6      Human NIPA1       Fly spict
spict P{EP}spict[EP2202] 17033 This P{EP} insertion in 5' UTR is uncharacterized but is semi-lethal (unverified), suggesting it may cause loss of function, 9/20/10
spict P{TRiP.HMS01647}attP40 37505 Expresses dsRNA for RNAi of spict (FBgn0032451) under the control of UAS.
spict P{TRiP.GLC01402}attP2 44438 Expresses dsRNA for RNAi of spict (FBgn0032451) under UAS control.
SPG7      Human SPG7/paraplegin      Fly CG2658
CG2658 P{TRiP.JF01781}attP2 31223 Expresses dsRNA for RNAi of CG2658 under UAS control.
CG2658 P{TRiP.JF01565}attP2 31100 Expresses dsRNA for RNAi of CG2658 under UAS control.
CG2658 P{TRiP.HMJ21885}attP40 57843 Expresses dsRNA for RNAi of CG2658 (FBgn0024992) under UAS control.
CG2658 P{TRiP.HMC04011}attP40 55324 Expresses dsRNA for RNAi of CG2658 (FBgn0024992) under UAS control.
SPG10      Human KIF5A      Fly Khc
Khc Khc[8] 1607 amorphic mutation (R210stop) in Khc
Khc PBac{RB}Khc[e02141] 18018 PBac{RB} insertion 5' of Khc, has phenotypes consistent with Khc reduction or loss of function
Khc P{lacW}Khc[k13314] 11084 P{lacW} insertion into the 5' UTR of Khc, has phenotypes consistent with Khc reduction or loss of function
Khc P{lacW}Khc[k13219] 11077 P{lacW} insertion into the 5' UTR of Khc, has phenotypes consistent with Khc reduction or loss of function
Khc Khc[1ts] 31994 temperature-sensitive hypomorphic mutation in Khc
Khc Khc[4] 31995 Khc mutant with T291M change
Khc P{TRiP.JF01939}attP2 25898 Expresses dsRNA for RNAi of Khc under UAS control.
Khc P{TRiP.HMS01519}attP2 35770 Expresses dsRNA for RNAi of Khc (FBgn0001308) under the control of UAS.
Khc P{TRiP.GL00330}attP2 35409 Expresses dsRNA for RNAi of Khc (FBgn0001308) under the control of UAS.
Khc P{KZ.TRAP}KZ1138 8766 Expresses a kinesin-lacZ fusion protein in ventral and lateral chordotonal neurons.
Khc P{UAS-Khc.EGFP}2 9648 Expresses the Khc head domain (bp 248-2143) tagged with GFP under the control of UAS.
SPG13      Human Hsp60      Fly Hsp60
SPG17      Human BSCL2/seipin      Fly Seipin
Seipin P{TRiP.HMS01643}attP40 37501 Expresses dsRNA for RNAi of Seipin (FBgn0040336) under the control of UAS.
SPG20      Human spartin       Fly spartin
spartin P{TRiP.HMS01641}attP40 37499 Expresses dsRNA for RNAi of CG12001 (FBgn0037265) under the control of UAS.
SPG31      Human REEP1       Fly CG42678