Stock Center logo
Huntington disease
Huntington disease is progressive neurodegenerative disorder leading to muscle coordination problems, loss of motor function, and mental decline. Huntington disease is one of several diseases caused by an increase in the number of CAG repeats within the coding region of the disease gene (in this case the Huntingtin/HTT gene) and subsequent translation of those repeats into an expanded polyglutamine (polyQ) tract in the protein. Fly stocks in the Bloomington collection that can be used to study Huntington disease are listed here.

General information links for Huntington disease:
OMIM
NIH's Genetics Home Reference" - includes links for the GHR pages on HTT
NLM/NIH's Genetic and Rare Disease Information Center
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human Huntingtin (HTT)       Fly huntingtin (htt)
htt P{TRiP.JF01205}attP2 31264 Expresses dsRNA for RNAi of htt under UAS control.
htt P{TRiP.HMS02845}attP2 44550 Expresses dsRNA for RNAi of htt (FBgn0027655) under UAS control.
htt Mi{PT-GFSTF.1}htt[MI04607-GFSTF.1] 60215 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of htt tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
htt P{UAS-HTT.96Q.Emerald}3 56774 Expresses the first coding exon of human HTT encoding 96 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.96Q.Emerald}2 56773 Expresses the first coding exon of human HTT encoding 96 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.96Q.Cerulean}3 56772 Expresses the first coding exon of human HTT encoding 96 glutamines fused to Cerulean fluorescent protein under UAS control.
htt P{UAS-HTT.96Q.Cerulean}2 56771 Expresses the first coding exon of human HTT encoding 96 glutamines fused to Cerulean fluorescent protein under UAS control.
htt P{UAS-HTT.72Q.Emerald}3 58361 Expresses the first coding exon of human HTT encoding 72 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.72Q.Emerald}2 56775 Expresses the first coding exon of human HTT encoding 72 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.46Q.Emerald}3 56777 Expresses the first coding exon of human HTT encoding 46 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.46Q.Emerald}2 56776 Expresses the first coding exon of human HTT encoding 46 glutamines fused to Emerald fluorescent protein under UAS control.
htt P{UAS-HTT.25Q.Cerulean}2 58360 Expresses the first coding exon of human HTT encoding 25 glutamines fused to Cerulean fluorescent protein under UAS control.
HTT (human) P{UAS-HTT.16Q.FL}F24 33810 Expresses human HTT with a normal polyglutamine tract under the control of UAS
HTT (human) P{UAS-HTT.128Q.FL}f27b 33809 Expresses human HTT with an expanded polyglutamine tract under the control of UAS
HTT (human) P{UAS-HTT.128Q.FL}f27b 33808 Expresses human HTT with an expanded polyglutamine tract under the control of UAS
HTT (human) P{GMR-HTT.Q120}4.62 8534 Drives expression of human HTT with an expanded polyglutamine tract in the eye.
HTT (human) P{GMR-HTT.Q120}2.4 8533 Drives expression of human HTT with an expanded polyglutamine tract in the eye.
      Human HIP14 (ZDHHC17)       Fly Huntingtin-interacting protein14 (Hip14)
Hip14 Hip14[2] 39734 26bp deletion resulting in a premature stop codon at position 312
Hip14 Hip14[I25] 4111 A lethal allele of Hip14.
Hip14 Hip14[1] 39718 Mutant allele (C452Y) of Hip14
Hip14 P{TRiP.JF01167}attP2 31591 Expresses dsRNA for RNAi of Hip14 under UAS control.
Hip14 P{TRiP.HMS01422}attP2 35012 Expresses dsRNA for RNAi of Hip14 (FBgn0259824) under the control of UAS.
Hip14 P{UAS-Hip14.O}2 42697 Expresses Hip14 under UAS control.
Hip14 Hip14[EP3292] 17109 This P{EP} insertion 444 bp 5prime is oriented such that it can overexpress Hip14 in the presence of GAL4.
      general polyglutamine (pQ) containing stocks
20 Qs P{UAS-ZzzzCAG.20Q}3 30549 Expresses a C-terminally HA-tagged 20 amino acid polyglutamine tract flanked N-terminally by 8 non-glutamine aa and C-terminally by 13 non-glutamine aa under UAS control.
41 Qs P{UAS-41Q.HA}3 30540 Expresses a C-terminally HA-tagged 41 amino acid polyglutamine tract under UAS control.
48 Qs P{UAS-Q48.myc/flag}42 51674 Expresses 48 glutamines tagged with FLAG and Myc.
63 Qs P{UAS-ZzzzCAG.63Q}2 30544 Expresses a C-terminally HA-tagged 63 amino acid polyglutamine tract under UAS control.