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Non-syndromic X-linked mental retardation
Approximately 14 causitive genes have been identified for non-syndromic X-linked mental retardation (MRX). Non-syndromic intellectual disabilities are typified by a lack of other abnormalities (syndromic X-linked mental retardation or MRXS is generally accompanied by other specific distinguishing features). Fly stocks in the Bloomington collection that can be used to study MRX are listed here.

General information links for MRX:
A list of MRX-associated genes can be found here.
shortcut to gene in table MRX subtype Human gene(s) full name Human gene(s) symbol Fly gene(s)
MRX1 IQ motif- and SEC7 domain-containing protein 2 IQSEC2 schizo (siz) (most similar to IQSEC1)
MRX9 FTSJ Homolog 1 FTSJ1 CG5220
MRX21/34 Interleukin 1 receptor accessory protein-like 1 IL1RAPL1
pak
MRX30/47 p21-activated kinase 3 PAK3 Pak-kinase (Pak)
acsl
MRX63/68 Acyl-CoA synthetase long chain family member 3 and 4 ACSL3 and ACSL4 Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3)
rab39
MRX72 Ras-associated protein RAB39B RAB39B Rab39
MRX88 Angiotensin II receptor, type 2 AGTR2
MRX89 Zinc finger protein 41 ZNF41
dlg
MRX90 Discs large, Drosophila, homolog of, 3 DLG3 dlg1 (most similar to DLG1)
MRX92 Zinc finger protein 674 ZNF674
brwd3
MRX93 Bromodomain- and WD repeat-containing protein 3 BRWD3 BRWD3 (most similar to BWRD1)
gluRI
MRX94 Glutamate receptor, ionotropic, AMPA 3 GRIA3 GluRIA and GluRIB
MRX95 Magnesium transporter 1 MAGT1
MRXARX Aristaless-related homeobox, X-linked ARX
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
   Human PAK3       Fly Pak
Pak Pak[6] 8809 Mutation in CRIB domain (R113stop)
Pak Pak[11] 8810 Amino acid change Q227stop results in a truncated protein of about 46 kD
Pak Pak[16] 9124 Amino acid change Q230stop
Pak Pak[14] 9123 Amino acid change W111stop.
Pak P{TRiP.HMS02279}attP40 41714 Expresses dsRNA for RNAi of Pak (FBgn0014001) under UAS control.
Pak P{TRiP.HMC05208}attP40 62201 Expresses dsRNA for RNAi of Pak (FBgn0014001) under UAS control.
Pak P{TRiP.HM05156}attP2 28945 Expresses dsRNA for RNAi of Pak (FBgn0014001) under UAS control.
Pak P{TRiP.GL00008}attP2 35141 Expresses dsRNA for RNAi of Pak (FBgn0014001) under the control of UAS.
Pak P{UASp-GFP-Pak1}300 52299 Expresses GFP-tagged Pak1 protein under UASp control.
Pak P{UASp-GFP-Pak1}20 53266 Expresses GFP-tagged Pak1 protein under UASp control.
Pak P{UAS-Pak.myr}2 8804 Expresses a constitutively-active, membrane-bound Pak protein under UAS control.
Pak P{UASp-Pak.RBD-GFP}30 56548 Rac/Cdc42 GTPase activity biosensor. Expresses the Rac/Cdc42 binding domain of Pak1 fused to GFP under UAS control.
Pak P{sqh-Pak1.RBD-GFP}31 56550 Rac/Cdc42 GTPase activity biosensor. Constitutively expresses the Rac/Cdc42 binding domain of Pak1 fused to GFP under control of sqh regulatory sequences.
Pak P{sqh-Pak1.RBD-GFP}21 56549 Rac/Cdc42 GTPase activity biosensor. Constitutively expresses the Rac/Cdc42 binding domain of Pak1 fused to GFP under control of sqh regulatory sequences.
   Human ACSL3 and ACSL4      Fly Acsl
Acsl Df(2R)Acsl[KO] 32331 Df takes out most of Acsl and all of tRNA:L2:44EF
Acsl P{PZ}Acsl[05847] & UAS-Acsl 32330 Expresses a C-terminally Myc-tagged 715 amino acid isoform of Acsl under the control of UAS in the presence of a P{PZ}Acsl[05847] loss of function allele.
Acsl P{PZ}Acsl[05847] 11452 PZ insertion in first intron causes loss of function
Acsl P{lacW}Acsl[k10313] 10433 lacW insertion in first intron causes loss of function
Acsl Acsl[8] 5496 Acsl (multiple mutations including K294E, Q419R and W685stop); Acsl[8] is the strongest allele
Acsl Acsl[8] 8188 Acsl[8] on a FRT-bearing chromosome for making clones.
Acsl Acsl[1] 5495 Acsl allele (amino acid change V594D)
Acsl P{TRiP.JF02811}attP2 27729 Expresses dsRNA for RNAi of Acsl under UAS control.
Acsl P{TRiP.HMS02307}attP40 41885 Expresses dsRNA for RNAi of Acsl (FBgn0263120) under UAS control.
Acsl P{TRiP.GLC01457}attP2 43268 Expresses dsRNA for RNAi of Acsl (FBgn0263120) under UAS control.
Acsl Mi{PT-GFSTF.2}Acsl[MI02966-GFSTF.2] 59291 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Acsl tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Acsl UAS-Acsl & P{PZ}Acsl[05847] 32330 Expresses a C-terminally Myc-tagged 715 amino acid isoform of Acsl under the control of UAS in the presence of a P{PZ}Acsl[05847] loss of function allele.
ACSL4 (human) P{UAS-ACSL4.L.Myc}3 64682 Expresses a C-terminally Myc-tagged long form of the human ACSL4 protein under the control of UAS.
ACSL4 (human) P{UAS-ACSL4.L.R570S}2 32329 Expresses a C-terminally Myc-tagged long form of human ACSL4 with MRX-associated mutation R570S under the control of UAS.
ACSL4 (human) P{UAS-ACSL4.L.P375L}3 32328 Expresses a C-terminally Myc-tagged long form of human ACSL4 with MRX-associated mutation P375L under the control of UAS.
   Human RAB39B       Fly Rab39
Rab39 P{TRiP.JF01973}attP2 25953 Expresses dsRNA for RNAi of Rab39 (FBgn0029959) under UAS control
Rab39 P{TRiP.HMJ21399}attP40 53995 Expresses dsRNA for RNAi of Rab39 (FBgn0029959) under UAS control.
Rab39 P{TRiP.GLC01791}attP2 51689 Expresses dsRNA for RNAi of Rab39 (FBgn0029959) under UAS control.
Rab39 TI{TI}Rab39[EYFP] 62560 Homologous recombination was used to swap EYFP and myc for the start codon of Rab39, resulting in expression of Rab39 tagged with EYFP and myc at the N-terminus under the control of Rab39 regulatory sequences.
Rab39 P{UASp-YFP.Rab39}13 9825 Expresses a YFP-tagged, wild type Rab39 protein under UAS control
Rab39 P{UAST-YFP.Rab39.S23N}Ir76b[05] 9824 Expresses a dominant negative, YFP-tagged Rab39 protein under UAS control
Rab39 P{UAST-YFP.Rab39.S23N}04 23247 Expresses a dominant negative, YFP-tagged Rab39 protein under UAS control
Rab39 P{UASp-YFP.Rab39.Q69L}14 9823 Expresses a constitutively active, YFP-tagged Rab39 protein under UAS control
Rab39 P{UASp-YFP.Rab39.Q69L}02 9822 Expresses a constitutively active, YFP-tagged Rab39 protein under UAS control
Rab39 PBac{I-SceI(FRT.Rab39-GAL4.ATG(loxP.3xP3-RFP))}VK00033 51600 Expresses GAL4 in the pattern of the Rab39 gene.
    Human DLG3       Fly dlg1
dlg1 dlg1[B] 57087 An allele of dlg1 (Splice donor mutation - T to A at position X:11395793, release 6 coord)
dlg1 dlg1[A] 57086 An allele of dlg1 (aa change Q551@)
dlg1 dlg1[5] 36280 Loss of function allele.
dlg1 dlg1[18] 36279 Loss of function allele caused by nucleic acid change C2752T which results in a stop codon and truncation of the protein in the GK (GUK) domain.
dlg1 dlg1[14] 36283 A splice donor mutation at intron 5 results in an unstable truncated protein containing PDZ1, PDZ2 and the beginning of PDZ3 domain.
dlg1 dlg1[2] 36278 Temperature-sensitive allele of dlg1.
dlg1 P{lacW}dlg1[G0456] 12301 largely uncharacterized lethal insertion (is rescued by a duplication carrying dlg1)
dlg1 P{TRiP.JF02287}attP2 36771 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{TRiP.JF01694}attP2 31181 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under UAS control
dlg1 P{TRiP.JF01365}attP2 25780 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under UAS control
dlg1 P{TRiP.JF01077}attP2 31521 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under UAS control
dlg1 P{TRiP.JF01076}attP2 31520 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under UAS control
dlg1 P{TRiP.HMS01954}attP40 39035 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under UAS control.
dlg1 P{TRiP.HMS01521}attP2 35772 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{TRiP.HMS00172}attP2 34854 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{TRiP.HMS00024}attP2 33629 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{TRiP.HMS00014}attP2 33620 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{TRiP.GL00188}attP2 35286 Expresses dsRNA for RNAi of dlg1 (FBgn0001624) under the control of UAS.
dlg1 P{PTT-GC}dlg1[YC0005] 50859 The P{PTT-GC} insertion is likely a protein trap for dlg1.
dlg1 Mi{PT-GFSTF.0}dlg1[MI06353-GFSTF.0] 59417 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of dlg1 tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
    Human BRWD3       Fly BRWD3
BRWD3 P{lacW}BRWD3[s5349] 35824 P{lacZ} insertion at bp 955 (in coding sequence) causes a strong loss of function allele.
BRWD3 P{PZ}BRWD3[05842] 12155 lethal insertion in BRWD3
BRWD3 BRWD3[PX1] 35560 An imprecise excision of {lacW}BRWD3[s5349] has deleted from +328 (in exon 2) to +1999 (in exon 6) relative to the start of the BRWD3 coding region.
BRWD3 P{TRiP.HMS00304}attP2 33421 Expresses dsRNA for RNAi of BRWD3 (FBgn0011785) under the control of UAS.
    Human GRIA3       Fly GluRIA and GluRIB
GluRIA P{TRiP.JF02671}attP2 27521 Expresses dsRNA for RNAi of GluRIA (FBgn0004619) under UAS control
GluRIA P{TRiP.HMS02155}attP2 40907 Expresses dsRNA for RNAi of Glu-RI (FBgn0004619) under UAS control.
GluRIA P{TRiP.HMS02010}attP40 40844 Expresses dsRNA for RNAi of Glu-RI (FBgn0004619) under UAS control.
GluRIA P{UAS-GluRIA.lurcher}2 8232 Expresses Glu-RI with the equivalent of the mouse 'lurcher' mutation under the control of UAS.
GluRIA P{GMR-GluRIA.lurcher}3 8235 Expresses Glu-RI with the equivalent of the mouse 'lurcher' mutation in the eye.
GluRIA P{GMR-GluRIA.lurcher}2 8234 Expresses Glu-RI with the equivalent of the mouse 'lurcher' mutation in the eye.
GluRIA P{GMR-GluRIA.lurcher}1 8233 Expresses Glu-RI with the equivalent of the mouse 'lurcher' mutation in the eye.
GluRIB PBac{WH}GluRIB[f01757] 18468 This PBac{WH} insertion (in the 14th intron) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 3/21/2011.
GluRIB Mi{MIC}GluRIB[MI00476] 31018 This Mi{MIC} insertion (in the 5th intron) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 3/21/2011.
GluRIB P{TRiP.JF02752}attP2 27673 Expresses dsRNA for RNAi of GluRIB (FBgn0028431) under UAS control
GluRIB P{TRiP.HMS02383}attP2 41985 Expresses dsRNA for RNAi of GluRIB (FBgn0264000) under UAS control.
GluRIB P{TRiP.HMS02156}attP40 40908 Expresses dsRNA for RNAi of GluRIB,CG42509 (FBgn0264000) under UAS control.