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Metabolism/Diabetes/Obesity
Metabolic dysfunction is associated with a wide variety of human disorders and health-related issues, including cardiovascular disease, diabetes, and obesity. Many of the genes and tissues involved in energy homeostasis, carbohydrate and lipid metabolism, nutrient uptake and storage, and other basic metabolic functions are conserved in flies. Fly stocks in the Bloomington collection that can be used to study human metabolism and related diseases and conditions such as diabetes and obesity are listed here. Other metabolic diseases for which we currently have pages include Niemann-Pick disease and Neuronal ceroid lipofuscinosis.

Jason Tennessen has generated a downloadable Excel spreadsheet of Drosophila genes predicted or known to function in metabolic pathways. Get the list here.
shortcut to gene in table Protein type Human gene(s) full name Human gene(s) symbol Fly gene(s)
1
 acyl-CoA dehydrogenases     Enigma (Egm)
2
 acyl-CoA synthetases acyl-CoA synthetase bubblegum family member 2 ACSBG2 bubblegum (bgm)
3
 long chain acyl-CoA synthases Acyl-CoA synthetase long chain family member 3 and 4 ACSL3 and ACSL4 Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3)
4
 AKT (Protein kinase B/PKB) kinases AKT3 (PKB-gamma) AKT3 Akt1
5
 diacylglycerol O-acyltransferases diacylglycerol O-acyltransferase 1 DGAT1 midway (mdy)
6
 4E-BPs Eukaryotic translation initiation factor 4E-binding proteins 1, 2, & 3 EIF4EBP1, EIF4EBP2, and EIF4EBP3 Thor (most similar to EIF4EBP2)
7
 nucleoside solute carriers solute carrier family 29 (nucleoside transporters), member 3 SLC29A3 Equilibrative nucleoside transporter 1 (Ent1)
8
   forkhead box protein O1A FOXO1A

forkhead box, sub-group O (foxo)
9
 FERM domain containing proteins FERM domain containing 6 FRMD6

expanded (ex)
10
   glucagon GCG Adipokinetic hormone (Akh) (functional homolog)
11
   Hepatocyte nuclear factor 4-alpha HNF4A Hepatocyte nuclear factor 4 (Hnf4)
12
   Insulin INS Insulin-like peptides: Ilp1, Ilp2, Ilp3, Ilp4, Ilp5, Ilp6, and Ilp7
13
 Insulin and IGF receptors Insulin receptor and insulin-like growth factor 1 receptor INSR and IGF1R (respectively) Insulin receptor (InR)
14
 Insulin receptor substrates Insulin receptor substrate 1 IRS1 chico
15
       mir-14
16
   MAP kinase interacting serine/threonine kinase 1 Mnk/MKNK1 Lk6
17
   mammalian Target of Rapamycin mTOR/FRAP1 Tor
18
 Pi3 kinases Phosphatidylinositol 3-Kinase, Class 2, Alpha PIK3C2A Phosphotidylinositol 3 kinase 68D (Pi3K68D)
19
 Pi3 kinases Phosphatidylinositol 3-Kinase, catalytic, beta PIK3CB Pi3K92E
20
   Perilipin 1 PLIN1 Lipid storage droplet-2 (Lsd-2)
21
   patatin-like phospholipase domain containing 2 PNPLA2/ATGL brummer (bmm)
22
   patatin-like phospholipase domain containing 6 PNPLA6/NTE swiss cheese (sws)
23
   Phosphatase and tensin homolog PTEN Pten
24
   SREBP cleavage-activating protein SCAP SCAP
25
 stearyl-CoA desaturases stearyl-CoA desaturase 1 SCD1 Desat1
26
   Sphingosine-1-phosphate lyase SGPL1 sphingosine-1-phosphate lyase (Sply)
27
 mitochondrial solute carriers solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 SLC25A1/CTP scheggia (sea)
28
 mitochondrial solute carriers solute carrier family 25 (mitochondrial carrier; adenine transporter), member 4 SLC25A4/ANT1 stress-sensitive B (sesB)
29
 mitochondrial solute carriers solute carrier family 25, member 30 (an uncoupling protein or UCP) SLC25A30 Bmcp
30
 SREBPs Sterol regulatory element-binding protein SREBP/SREBPF1 SREBP
31
   Hamartin TSC1 Tsc1
32
   Tuberin TSC2 gigas (gig)
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
1.     Human acyl-CoA dehydrogenases       Fly Enigma (Egm)
Egm P{lacW}Egm[k14708] 11133 Egm loss of function allele (lacW insertion at the beginning of the first exon)
Egm P{TRiP.HMS01630}attP40 36739 Expresses dsRNA for RNAi of Egm (FBgn0086712) under the control of UAS.
2.     Human acyl-CoA synthase bubblegum 2      Fly bubblegum (bgm)
bgm P{lacW}bgm[1] 28120 bgm mutant (lacW insertion in first intron)
bgm P{TRiP.JF03054}attP2 28639 Expresses dsRNA for RNAi of bgm under UAS control.
bgm P{TRiP.HMC04419}attP40 56979 Expresses dsRNA for RNAi of bgm (FBgn0027348) under UAS control.
bgm P{TRiP.HMC04204}attP2 55918 Expresses dsRNA for RNAi of bgm (FBgn0027348) under UAS control.
3.     Human ACSL3 and ACSL4      Fly Acsl
Acsl Df(2R)Acsl[KO] 32331 Df takes out most of Acsl and all of tRNA:L2:44EF
Acsl P{PZ}Acsl[05847] & UAS-Acsl 32330 Expresses a C-terminally Myc-tagged 715 amino acid isoform of Acsl under the control of UAS in the presence of a P{PZ}Acsl[05847] loss of function allele.
Acsl P{PZ}Acsl[05847] 11452 PZ insertion in first intron causes loss of function
Acsl P{lacW}Acsl[k10313] 10433 lacW insertion in first intron causes loss of function
Acsl Acsl[8] 5496 Acsl (multiple mutations including K294E, Q419R and W685stop); Acsl[8] is the strongest allele
Acsl Acsl[8] 8188 Acsl[8] on a FRT-bearing chromosome for making clones.
Acsl Acsl[1] 5495 Acsl allele (amino acid change V594D)
Acsl P{TRiP.JF02811}attP2 27729 Expresses dsRNA for RNAi of Acsl under UAS control.
Acsl P{TRiP.HMS02307}attP40 41885 Expresses dsRNA for RNAi of Acsl (FBgn0263120) under UAS control.
Acsl P{TRiP.GLC01457}attP2 43268 Expresses dsRNA for RNAi of Acsl (FBgn0263120) under UAS control.
Acsl UAS-Acsl & P{PZ}Acsl[05847] 32330 Expresses a C-terminally Myc-tagged 715 amino acid isoform of Acsl under the control of UAS in the presence of a P{PZ}Acsl[05847] loss of function allele.
ACSL4 (human) P{UAS-ACSL4.L.Myc}3 64682 Expresses a C-terminally Myc-tagged long form of the human ACSL4 protein under the control of UAS.
ACSL4 (human) P{UAS-ACSL4.L.R570S}2 32329 Expresses a C-terminally Myc-tagged long form of human ACSL4 with MRX-associated mutation R570S under the control of UAS.
ACSL4 (human) P{UAS-ACSL4.L.P375L}3 32328 Expresses a C-terminally Myc-tagged long form of human ACSL4 with MRX-associated mutation P375L under the control of UAS.
4.     Human AKT3       Fly Akt1
Akt1 P{PZ}Akt1[04226] 11627 Hypomorphic PZ insertion in the 5' UTR of Akt1.
Akt1 P{EPgy2}Akt1[EY10012] 19894 P{EYgy2} insertion into non-coding exon 1 causes an Akt1 mutant.
Akt1 Mi{MIC}Akt1[MI14526] 59527 Uncharacterized insertion but is an unverified lethal suggesting it may disrupt function.
Akt1 P{TRiP.HMS00007}attP2 33615 Expresses dsRNA for RNAi of Akt1 (FBgn0010379) under the control of UAS.
Akt1 P{TRiP.HMJ21422}attP40 54002 Expresses dsRNA for RNAi of Akt1 (FBgn0010379) under UAS control.
Akt1 P{TRiP.HM04007}attP2 31701 Expresses dsRNA for RNAi of Akt1 under UAS control.
Akt1 P{UAS-Akt1.Exel}2 8191 Expresses wild type Akt1 under the control of UAS.
Akt1 P{UAS-Akt1.Exel}1 8192 Expresses wild type Akt1 under the control of UAS.
Akt1 P{GMR-Akt1.Exel}2 8196 Expresses wild type Akt1 in the eye.
Akt1 P{GMR-Akt1.Exel}1 8195 Expresses wild type Akt1 in the eye.
Akt1 P{UAS-myr-Akt1.V}3 50758 Expresses a constitutively active Akt1 with a myristoylation motif under UAS control.
Akt1 P{GMR-Akt1.T342D.S505D}2 8194 Expresses constitutively active Akt1 in the eye.
Akt1 P{GMR-Akt1.T342D.S505D}1 8193 Expresses constitutively active Akt1 in the eye.
5.     Human diacylglycerol O-acyltransferase 1/DGAT1       Fly mdy
mdy mdy[QX25] 5095 mdy mutant (EMS-induced W499stop)
mdy mdy[k03902] 10536 lacW insertion into the 4th intron of mdy and the first intron of Cas (insertion likely makes a Cas null)
mdy P{TRiP.HMC06242}attP40 65963 Expresses dsRNA for RNAi of mdy (FBgn0004797) under UAS control.
mdy PBac{IT.GAL4}mdy[0626-G4] 63453 May express GAL4 in some or all of the pattern of the mdy gene.
6.     Human EIF4EBP1, EIF4EBP2, and EIF4EBP3       Fly Thor
Thor Thor[2] 9559 Deletion of Thor sequences
Thor P{lacW}Thor[k13517] 9558 Thor hypomorphic allele (lacW insertion adjacent to TATA box)
Thor P{TRiP.HMS01555}attP40 36667 Expresses dsRNA for RNAi of Thor (FBgn0261560) under the control of UAS.
Thor P{TRiP.GL01034}attP2 36815 Expresses dsRNA for RNAi of Thor (FBgn0261560) under the control of UAS.
Thor P{UAS-Thor.wt}3 8649 Expresses wild type Thor under the control of UAS.
Thor P{UAS-Thor.wt}2 9147 Expresses wild type Thor under the control of UAS.
Thor P{UAS-Thor.LL}s 8651 Expresses a mutant Thor protein that binds eIF-4E more strongly than the wild type protein under the control of UAS.
Thor P{UAS-Thor.LL}s 24854 Expresses a mutant Thor protein that binds eIF-4E more strongly than the wild type protein under the control of UAS.
Thor P{PZ}Thor[06270] 11481 beta-galactosidase is expressed in the Thor pattern
7.     Human SLC29A3       Fly Ent1
Ent1 P{TRiP.HMJ21190}attP40 51055 Expresses dsRNA for RNAi of Ent1 (FBgn0031250) under UAS control.
Ent1 P{EP}Ent1[EP2066] 17019 EP insertion just 5' of the Ent1 transcription start. Will overexpress Ent1 in the presence of GAL4.
8.     Human FOXO1A       Fly foxo
foxo foxo[Delta94] 42220 An imprecise excision of P{GT1}foxo[BG01018] has deleted over 20kb of the foxo gene, including part of the predicted promoter region as well as several coding exons.
foxo P{GT1}foxo[BG01018] 12530 GT1 insertion in foxo 5' UTR causes mild reductions in function
foxo P{TRiP.JF02734}attP2 27656 Expresses dsRNA for RNAi of foxo under UAS control.
foxo P{TRiP.JF02019}attP2 25997 Expresses dsRNA for RNAi of foxo under UAS control.
foxo P{TRiP.HMS00793}attP2 32993 Expresses dsRNA for RNAi of foxo (FBgn0038197) under the control of UAS.
foxo P{TRiP.HMS00422}attP2 32427 Expresses dsRNA for RNAi of foxo (FBgn0038197) under the control of UAS.
foxo Mi{PT-GFSTF.0}foxo[MI00493-GFSTF.0] 59766 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of foxo tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
foxo P{UASp-foxo.S}3 42221 Expresses foxo under UAS control.
foxo P{UASp-foxo.GFP}3 43633 Expresses GFP-tagged foxo protein under UAS control.
foxo P{UASp-foxo.GFP}2 44214 Expresses GFP-tagged foxo protein under UAS control.
foxo P{UAS-foxo.P}2 9575 Expresses foxo under the control of UAS.
foxo PBac{foxo-GFP.FLAG}VK00037 38644 Expresses GFP- and FLAG-tagged foxo protein under the control of its own promoter.
foxo P{EPgy2}foxo[EY11248] 20279 EPgy2 insertion upstream of transcription start site. May overexpress foxo in the presence of GAL4.
foxo PBac{IT.GAL4}foxo[1003-G4] 63953 May express GAL4 in some or all of the pattern of the foxo gene.
9.     Human Ferm domain containing 6      Fly expanded (ex)
ex ex[e1] 44249 small deletion that removes 5prime end of gene resulting in a loss of function or amorphic allele
ex ex[BQ] 39689 Loss of function allele resulting from a stop codon at position 32.
ex P{lacW}ex[k12913] 11067 ex mutant (lacW insertion in first exon of ex)
ex P{lacW}ex[697] 44248 This P{lacW} insertion is an ex mutant and also expresses lacZ in the pattern of the ex gene throughout imaginal disks.
ex ex[1] 295 ex mutant
ex P{TRiP.JF03120}attP2 28703 Expresses double-stranded RNA for RNAi of ex under UAS control.
ex P{TRiP.HMS00874}attP2 34968 Expresses dsRNA for RNAi of ex (FBgn0004583) under the control of UAS.
10.     Human glucagon       Fly functional homolog Adipokinetic hormone (Akh)
Akh P{TRiP.JF02357}attP2 27031 Expresses dsRNA for RNAi of Akh under UAS control.
Akh P{TRiP.HMS00477}attP2 34960 Expresses dsRNA for RNAi of Akh (FBgn0004552) under the control of UAS.
Akh P{UAS-Akh.L}2 27343 Expresses Adipokinetic Hormone under UAS control.
Akh P{Akh-gal4.L}3 25684 Expresses GAL4 in the Adipokinetic hormone-secreting cells of the corpora cardiaca.
Akh P{Akh-gal4.L}2 25683 Expresses GAL4 in the Adipokinetic hormone-secreting cells of the corpora cardiaca.
11.     Human HNF4A       Fly Hnf4
Hnf4 Hnf4[Delta17] 44218 Made by an Imprecise excision of P{EP}Hnf4[EP2449]. Deletion takes out an 8193 bp region, removing most of the Hnf4 coding region along with three adjacent genes.
Hnf4 P{UAS-Hnf4.miRNA}attP16 44398 Expresses a miRNA knocking down expression of Hnf4.
Hnf4 P{TRiP.JF02539}attP2 29375 Expresses dsRNA for RNAi of Hnf4 under UAS control.
Hnf4 P{TRiP.HMC05862}attP40 64988 Expresses dsRNA for RNAi of Hnf4 (FBgn0004914) under UAS control.
Hnf4 Mi{PT-GFSTF.1}Hnf4[MI05541-GFSTF.1] 60230 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Hnf4 tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Hnf4 PBac{Hnf4-GFP.FLAG}VK00033 38649 Expresses GFP- and FLAG-tagged Hnf4 under the control of its own promoter.
Hnf4 P{hs-GAL4-Hnf4.LBD.HA}57.51 28856 Expresses an HA-tagged GAL4 DNA binding domain fused to the ligand binding domain of Hnf4 upon heat shock for GFP detection of cells under ligand control.
12.     Human Insulin      Fly Ilp1, Ilp2, Ilp3, Ilp4, Ilp5, Ilp6, and Ilp7
Ilp1 Ilp1[1] 30880 Ends-out gene replacement of Ilp1 with w[+].
Ilp1 P{TRiP.JF01344}attP2 31491 Expresses dsRNA for RNAi of Ilp1 under UAS control.
Ilp1 P{TRiP.HMS00648}attP2 32861 Expresses dsRNA for RNAi of Ilp1 (FBgn0044051) under the control of UAS.
Ilp1 P{TRiP.HMJ22151}attP40 58174 Expresses dsRNA for RNAi of Ilp1 (FBgn0044051) under UAS control.
Ilp1 P{Ilp1-GAL4.L}4 66005 Expresses GAL4 under the control of Ilp1.
Ilp1 P{Ilp1-GAL4.L}1 66006 Expresses GAL4 under the control of Ilp1.
Ilp1-5 Df(3L)Ilp1-4, Ilp5[4] 30890 Ends-out gene replacements of Ilp1, Ilp2, Ilp3 and Ilp4 with w[+] and Ilp5 with w[+].
Ilp1-5, 7 Ilp7[1]; Df(3L)Ilp1-4, Ilp5[4] 30894 Ends-out gene replacements of Ilp1, Ilp2, Ilp3 and Ilp4 with w[+] and Ilp5 with w[+] and Ilp7 with w[+].
Ilp2 Ilp2[1] 30881 Ends-out gene replacement of Ilp2 with w[+].
Ilp2 P{TRiP.JF01518}attP2 31068 Expresses dsRNA for RNAi of Ilp2 under UAS control.
Ilp2 P{TRiP.HMS00476}attP2 32475 Expresses dsRNA for RNAi of Ilp2 (FBgn0036046) under the control of UAS.
Ilp2 P{hs-Ilp2.R}2 37472 Expresses Ilp2 under the control of heatshock.
Ilp2 P{Ilp2-GAL4.R}2 37516 Expresses GAL4 under the control of Ilp2.
Ilp2, 3 Df(3L)Ilp2-3 30888 Ends-out gene replacement of Ilp2 and Ilp3 with w[+].
Ilp2, 3, 5 Df(3L)Ilp2-3 Ilp5[3] 30889 Ends-out gene replacements of Ilp2 and Ilp3 with w[+] and Ilp5 with w[+]; developmentally delayed homozygotes may be present.
Ilp2, 3, 5, 6 Df(1)Ilp6[68] Df(3L)Ilp2-3, Ilp5[3] 30891 Ends-out gene replacements of Ilp2 and Ilp3 with w[+] and Ilp5 with w[+]. Df(1)Ilp6[68] deletes Ilp6 as well as four other genes; it likely also deletes part of phl.
Ilp2, 3, 5, 6 Df(1)Ilp6[41] Df(3L)Ilp2-3, Ilp5[4] 30892 Ends-out gene replacements of Ilp2 and Ilp3 with w[+] and Ilp5 with w[+]. Df(1)Ilp6[41] removes the Ilp6 upstream region (including the first exon) but the ORF is in intact; it likely also deletes part of phl.
Ilp2, 3, 5, 7 Ilp7[1]; Df(3L)Ilp2-3, Ilp5[3] 30893 Ends-out gene replacements of Ilp2 and Ilp3 with w[+] and Ilp5 with w[+] and Ilp7 with w[+].
Ilp3 Ilp3[1] 30882 Ends-out gene replacement of Ilp3 with w[+].
Ilp3 P{TRiP.JF01345}attP2 31492 Expresses dsRNA for RNAi of Ilp3 under UAS control.
Ilp3 P{TRiP.HMS00546}attP2 33681 Expresses dsRNA for RNAi of Ilp3 (FBgn0044050) under the control of UAS.
Ilp3 P{Ilp3-GAL4.C}2 52660 Expresses GAL4 in insulin producing cells under the control of a Ilp3 promoter; see Cell 114:739-49, 2003.
Ilp4 Ilp4[1] 30883 Ends-out gene replacement of Ilp4 with w[+].
Ilp4 P{TRiP.JF01346}attP2 31377 Expresses dsRNA for RNAi of Ilp4 (FBgn0044049) under UAS control, TRiP.
Ilp4 P{TRiP.HMS02660}attP40 43288 Expresses dsRNA for RNAi of Ilp4 (FBgn0044049) under UAS control.
Ilp4 P{TRiP.HMS00547}attP2 33682 Expresses dsRNA for RNAi of Ilp4 (FBgn0044049) under the control of UAS.
Ilp5 Ilp5[1] 30884 Ends-out gene replacement of Ilp5 with w[+].
Ilp5 P{TRiP.JF01347}attP2 31378 Expresses dsRNA for RNAi of Ilp5 (FBgn0044048) under UAS control, TRiP.
Ilp5 P{TRiP.HMS00548}attP2 33683 Expresses dsRNA for RNAi of Ilp5 (FBgn0044048) under the control of UAS.
Ilp5 P{Ilp5-GAL4.L}8 66007 Expresses GAL4 under the control of Ilp5.
Ilp5 P{Ilp5-GAL4.L}3 66008 Expresses GAL4 under the control of Ilp5.
Ilp6 Df(1)Ilp6[68] 30886 Df(1)Ilp6[68] deletes Ilp6 as well as four other genes; it likely also deletes part of phl.
Ilp6 Df(1)Ilp6[41] 30885 Df(1)Ilp6[41] removes the Ilp6 upstream region (including the first exon) but the ORF is in intact; it likely also deletes part of phl.
Ilp6 P{TRiP.JF01348}attP2 31379 Expresses dsRNA for RNAi of Ilp6 under UAS control.
Ilp6 P{TRiP.HMS00549}attP2 33684 Expresses dsRNA for RNAi of Ilp6 (FBgn0044047) under the control of UAS.
Ilp6 P{GSV1}Ilp6[EP-63] 43430 P{GSV1} 'protein trap' - Should express GFP-tagged Ilp6 under endogenous Ilp6 control.
Ilp7 Ilp7[1] 30887 Ends-out gene replacement of Ilp7 with w[+]
Ilp7 P{TRiP.JF01519}attP2 31069 Expresses dsRNA for RNAi of Ilp7 under UAS control.
Ilp7 P{TRiP.HMS00649}attP2 32862 Expresses dsRNA for RNAi of Ilp7 (FBgn0044046) under the control of UAS.
13.     Human Insulin receptor and IGF1R      Fly Insulin receptor (InR)
InR P{PZ}InR[05545] 11661 InR mutant (PZ insertion into 1st coding exon)
InR InR[E19] 9646 InR mutant
InR InR[93Dj-4] 9554 InR mutant
InR InR[574] 63093 Amino acid change W1562stop
InR P{TRiP.JF01482}attP2 31037 Expresses dsRNA for RNAi of InR under UAS control.
InR P{TRiP.JF01183}attP2 31594 Expresses dsRNA for RNAi of InR under UAS control.
InR P{TRiP.HMS03166}attP40 51518 Expresses dsRNA for RNAi of InR (FBgn0013984) under UAS control.
InR P{TRiP.GL00139}attP2 35251 Expresses dsRNA for RNAi of InR (FBgn0013984) under the control of UAS.
InR P{UAS-InR.Exel}2 8262 Expresses wild type InR under the control of UAS.
InR P{sev-InR.Exel}3 8270 Expresses wild type InR in the eye.
InR P{sev-InR.Exel}2 8268 Expresses wild type InR in the eye.
InR P{sev-InR.Exel}1 8269 Expresses wild type InR in the eye.
InR P{GMR-InR.Exel}2 8267 Expresses wild type InR in the eye.
InR P{GMR-InR.Exel}1 8261 Expresses wild type InR in the eye.
InR P{EPgy2}InR[EY00681] 15306 This P{EPgy2} insertion in the first exon is oriented such that it can (and likely does) express InR in the presence of GAL4.
InR P{UAS-InR.K1409A}3 8253 Expresses a dominant negative InR under the control of UAS.
InR P{UAS-InR.K1409A}2 8252 Expresses a dominant negative InR under the control of UAS.
InR P{UAS-InR.K1409A}1 8251 Expresses a dominant negative InR under the control of UAS.
InR P{GMR-InR.K1409A}3 8260 Expresses a dominant negative InR in the eye.
InR P{GMR-InR.K1409A}2 8259 Expresses a dominant negative InR in the eye.
InR P{GMR-InR.K1409A}1 8258 Expresses a dominant negative InR in the eye.
InR P{UAS-InR.R418P}2 8250 Expresses a constitutively active InR under the control of UAS. The R418P amino acid change mimics the human K86P change.
InR P{UAS-InR.R418P}1 8528 Expresses a constitutively active InR under the control of UAS. The R418P amino acid change mimics the human K86P change.
InR P{UAS-InR.del}2 8248 Expresses a InR deleted for most of the alpha subunit (mimics a constitutively active human InR) in the developing eye.
InR P{UAS-InR.A1325D}3 8440 Expresses a constitutively active InR under the control of UAS. The A1325D amino acid change mimics the human V938D change.
InR P{UAS-InR.A1325D}2 8263 Expresses a constitutively active InR under the control of UAS. The A1325D amino acid change mimics the human V938D change.
InR P{GMR-InR.R418P}3 8256 Expresses a constitutively active InR in the eye. The R418P amino acid change mimics the human K86P change.
InR P{GMR-InR.R418P}2 8257 Expresses a constitutively active InR in the eye. The R418P amino acid change mimics the human K86P change.
InR P{GMR-InR.del}3 8255 Expresses a InR deleted for most of the alpha subunit (mimics a constitutively active human InR) in the developing eye.
InR P{GMR-InR.del}2 8254 Expresses a InR deleted for most of the alpha subunit (mimics a constitutively active human InR) under the control of UAS.
InR P{GMR-InR.A1325D}3 8264 Expresses a constitutively active InR in the eye. The A1325D amino acid change mimics the human V938D change.
InR P{GMR-InR.A1325D}2 8265 Expresses a constitutively active InR in the eye. The A1325D amino acid change mimics the human V938D change.
InR PBac{IT.GAL4}InR[0726-G4] 63762 May express GAL4 in some or all of the pattern of the InR gene.
InR PBac{IT.GAL4}InR[0488-G4] 63352 May express GAL4 in some or all of the pattern of the InR gene.
14.     Human Insulin receptor substrate 1      Fly chico
chico P{ry11}chico[1] 10738 null allele (P{ry11} insertion is in the PH domain, ~ 80bp downstream of the translation start site)
chico P{SUPor-P}chico[KG00032] 14337 P{SUPor-P} inserted into non-coding exon 1 reduces chico mRNA levels by 60% when homozygous.
chico P{TRiP.JF02964}attP2 28329 Expresses dsRNA for RNAi of chico under UAS control.
chico P{TRiP.HMS01553}attP2 36665 Expresses dsRNA for RNAi of chico (FBgn0024248) under the control of UAS.
chico P{TRiP.GL00525}attP40 36788 Expresses dsRNA for RNAi of chico (FBgn0024248) under the control of UAS.
15.     Fly mir-14
mir-14 mir-14[Delta1] 33067 An imprecise excision of P{lacW}mir-14[k10213] has deleted a 533bp deletion of the entire mir-14 gene.
mir-14 P{lacW}mir-14[k10213] 10982 miR-14 mutant (lacW insertion 172 bp from miR-14)
mir-14 P{UAS-mCherry.mir-14.sponge.V2}attP40 61382 Expresses an antisense 'sponge' RNA under UAS control for knocking down mir-14 expression.
mir-14 P{UAS-mCherry.mir-14.sponge.V2}attP2 61382 Expresses an antisense 'sponge' RNA under UAS control for knocking down mir-14 expression.
mir-14 P{UAS-LUC-mir-14.T}attP2 41178 Expresses mir-14 (FBgn0262447) under UAS control, TRiP.
mir-14 P{UAS-DsRed-mir-14}2 59868 Expresses mir-14 under UAS control.
16.     Human Mnk     Fly Lk6
Lk6 Lk6[2] 8707 Deletion that removes all of Lk6-RB and all but the first exon of Lk6-RA.
Lk6 Lk6[1] 8706 Semi-viable. Hypomorph. 3 kb deletion that removes an alternative 5' exon but leavesthe rest of the coding region intact such that Lk6-RB is affected but Lk6-RA is not.
Lk6 P{TRiP.JF02993}attP2 28357 Expresses dsRNA for RNAi of Lk6 under UAS control.
Lk6 P{TRiP.HMC04995}attP40 60003 Expresses dsRNA for RNAi of Lk6 (FBgn0017581) under UAS control.
Lk6 P{TRiP.GL00264}attP2 35352 Expresses dsRNA for RNAi of Lk6 (FBgn0017581) under the control of UAS.
Lk6 Mi{PT-GFSTF.1}Lk6[MI02556-GFSTF.1] 59795 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Lk6 tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Lk6 P{UAS-Lk6.A}1 8708 Wild type Lk6 expressed under the control of UAS; semi-viable.
Lk6 P{UAS-Lk6.T424D}6 8709 Constitutively-active Lk6 expressed under the control of UAS.
Lk6 P{GawB}Lk6[DJ634] 8614 Expresses GAL4 in fat body. Adult expression increases with age.
17.     Human mTOR/FRAP1      Fly Tor
Tor Tor[DeltaP] 7014 null allele - deletion that removes from ~200 bp upstream to ~3300 downstream of the transcription start site (deletes translation start site and first 902 codons).
Tor P{lacW}Tor[k17004] 11218 Tor mutation (lacW insertion)
Tor P{TRiP.HMS01114}attP2 34639 Expresses dsRNA for RNAi of Tor (FBgn0021796) under the control of UAS.
Tor P{TRiP.HMS00904}attP2 33951 Expresses dsRNA for RNAi of Tor (FBgn0021796) under the control of UAS.
Tor P{TRiP.GL00156}attP2 35578 Expresses dsRNA for RNAi of Tor (FBgn0021796) under the control of UAS.
Tor P{UAS-Tor.WT}III 7012 Expresses wildtype Tor under the control of UAS.
Tor P{UAS-Tor.myc}2 53727 Expresses myc-tagged Tor protein under UAS control.
Tor P{UAS-Tor.TED}II 7013 Expresses dominant negative Tor protein under the control of UAS.
18.     Human PIK3C2A       Fly Pi3K68D
Pi3K68D Mi{MIC}Pi3K68D[MI15179] 59605 This Mi{MIC} insertion in an intron in both Pi3K68D and CG14131 is uncharacterized but is an unverified lethal suggesting it may disrupt function.
Pi3K68D P{TRiP.JF01193}attP2 31252 Expresses dsRNA for RNAi of Pi3K68D under UAS control.
Pi3K68D P{TRiP.HMS01296}attP2 34621 Expresses dsRNA for RNAi of Pi3K68D (FBgn0015278) under the control of UAS.
Pi3K68D P{TRiP.GL00159}attP2 35265 Expresses dsRNA for RNAi of Pi3K68D (FBgn0015278) under the control of UAS.
19.     Human PIK3CB       Fly Pi3K92E
Pi3K92E Df(3R)Pi3K92E[A] 25900 Deficiency results in a truncated, and likely unstable, Pi3K92E protein missing the kinase domain and loss of H. Stock also contains a rescue construct for H.
Pi3K92E Df(3R)Pi3K92E[A] 25906 Expresses myc-tagged Pi3K92E (=Dp110) with a mutated Ras-binding domain from the Dp110 promoter. Stock also contains a deficiency for Pi3K92E and H and a rescue construct for H.
Pi3K92E Df(3R)Pi3K92E[A] 25917 Expresses myc-tagged Pi3K92E (=Dp110) from the Dp110 promoter. Stock also contains a deficiency for Pi3K92E and H and a rescue construct for H.
Pi3K92E Df(3R)Pi3K92E-B 25904 Deficiency removes Pi3K92E and H. Stock also contains a rescue construct for H.
Pi3K92E P{TRiP.JF02770}attP2 27690 Expresses dsRNA for RNAi of Pi3K92E under UAS control.
Pi3K92E P{TRiP.HMC05152}attP40 61182 Expresses dsRNA for RNAi of Pi3K92E (FBgn0015279) under UAS control.
Pi3K92E P{TRiP.GL00311}attP2 35798 Expresses dsRNA for RNAi of Pi3K92E (FBgn0015279) under the control of UAS.
Pi3K92E P{WT-Dp110}2 25914 Expresses myc-tagged Pi3K92E (=Dp110) under UAS control.
Pi3K92E P{UAS-Pi3K92E.Exel}3 8287 Expresses wild type Pi3K92E under the control of UAS.
Pi3K92E P{UAS-Pi3K92E.Exel}2 8286 Expresses wild type Pi3K92E under the control of UAS.
Pi3K92E P{Myc-Dp110}1 25915 Expresses myc-tagged Pi3K92E (=Dp110) from the Dp110 promoter.
Pi3K92E P{Myc-Dp110}1 25917 Expresses myc-tagged Pi3K92E (=Dp110) from the Dp110 promoter. Stock also contains a deficiency for Pi3K92E and H and a rescue construct for H.
Pi3K92E P{GMR-Pi3K92E.Exel}2 8293 Expresses wild type Pi3K92E in the eye.
Pi3K92E P{UAS-Pi3K92E.A2860C}3 8289 Expresses a dominant negative Pi3K92E under the control of UAS.
Pi3K92E P{UAS-Pi3K92E.A2860C}1 8288 Expresses a dominant negative Pi3K92E under the control of UAS.
Pi3K92E P{GMR-Pi3K92E.A2860C}2 8290 Expresses a dominant negative Pi3K92E in the eye.
Pi3K92E P{GMR-Pi3K92E.A2860C}1 8291 Expresses a dominant negative Pi3K92E in the eye.
Pi3K92E P{Dp110[D954A]}2 25918 Expresses myc-tagged Pi3K92E (=Dp110) with a defective ATP binding domain under UAS control.
Pi3K92E P{UAS-Pi3K92E.CAAX}1 8294 Expresses a constitutively active Pi3K92E with a farnesylation signal (CAAX) appended to the C terminus under UAS control.
Pi3K92E P{Dp110-CAAX}1 25908 Expresses myc-tagged Pi3K92E (=Dp110) with the polybasic region and CAAX box of mammalian K-Ras fused to the C-terminus for membrane targeting under UAS control.
Pi3K92E P{Myc-Dp110[RBD]}1 25916 Expresses myc-tagged Pi3K92E (=Dp110) with a mutated Ras-binding domain from the Dp110 promoter.
Pi3K92E P{Myc-Dp110[RBD]}1 25906 Expresses myc-tagged Pi3K92E (=Dp110) with a mutated Ras-binding domain from the Dp110 promoter. Stock also contains a deficiency for Pi3K92E and H and a rescue construct for H.
20.     Human Perilipin 1       Fly Lipid storage droplet-2 (Lsd-2)
Lsd-2 P{SUPor-P}Lsd-2[KG00149] 13382 null allele (P{SUPorP} insertion just 5' of the first exon)
Lsd-2 P{GT1}Lsd-2[BG00016] 12398 weak allele
Lsd-2 P{TRiP.HMS01292}attP2 34617 Expresses dsRNA for RNAi of Lsd-2 (FBgn0030608) under the control of UAS.
Lsd-2 P{TRiP.HMS00629}attP2 32846 Expresses dsRNA for RNAi of Lsd-2 (FBgn0030608) under the control of UAS.
21.     Human PNPLA2       Fly brummer (bmm)
bmm P{TRiP.JF01946}attP2 25926 Expresses dsRNA for RNAi of bmm under UAS control.
22.     Human PNPLA6/NTE       Fly swiss cheese (sws)
sws sws[olfE-x26] 1015 sws null mtant
sws sws[4] 28121 sws with G956D change
sws P{TRiP.JF03428}attP2 31993 Expresses dsRNA for RNAi of sws under UAS control.
sws P{TRiP.HMJ23229}attP40 61338 Expresses dsRNA for RNAi of sws (FBgn0003656) under UAS control.
sws P{TRiP.HMC04094}attP40 55406 Expresses dsRNA for RNAi of sws (FBgn0003656) under UAS control.
sws P{TRiP.GLC01426}attP2 43239 Expresses dsRNA for RNAi of sws (FBgn0003656) under UAS control.
23.     Human PTEN       Fly Pten
Pten P{UAS-Pten.dsRNA.Exel}3 8550 Expresses dsRNA for RNAi of Pten under UAS control.
Pten P{UAS-Pten.dsRNA.Exel}2 8549 Expresses dsRNA for RNAi of Pten under UAS control.
Pten P{UAS-Pten.dsRNA.Exel}1 8548 Expresses dsRNA for RNAi of Pten under UAS control.
Pten P{TRiP.JF01987}attP2 25967 Expresses dsRNA for RNAi of Pten under UAS control.
Pten P{TRiP.JF01859}attP2 25841 Expresses dsRNA for RNAi of Pten under UAS control.
Pten P{TRiP.HMS00044}attP2 33643 Expresses dsRNA for RNAi of Pten (FBgn0026379) under the control of UAS.
24.     Human SCAP (SREBP cleavage protein)      Fly SCAP
SCAP Mi{MIC}SCAP[MI00063] 30606 This Mi{MIC} insertion (in the second intron) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/9/2010.
SCAP Mi{ET1}SCAP[MB04378] 24578 This Mi{ET1} insertion (in the first intron) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/9/2010.
SCAP P{TRiP.JF01139}attP2 31566 Expresses dsRNA for RNAi of SCAP under UAS control.
SCAP Mi{PT-GFSTF.0}SCAP[MI00063-GFSTF.0] 64463 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of SCAP tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
SCAP P{UAS-SCAP.Exel}3 8351 Expresses wild type SCAP under UAS control.
SCAP P{UAS-SCAP.P450}3 8346 Expresses a dominant negative SCAP with an ER localization sequence added just C terminal of the final transmembrane domain.
SCAP P{UAS-SCAP.P450}1 8347 Expresses a dominant negative SCAP with an ER localization sequence added just C terminal of the final transmembrane domain.
SCAP P{UAS-SCAP.Y319C}3 8349 Expresses constitutively active SCAP with a Y319C amino acid change under UAS control. Y319C mimics the hamster Y298C change.
SCAP P{UAS-SCAP.Y319C}2 8350 Expresses constitutively active SCAP with a Y319C amino acid change under UAS control. Y319C mimics the hamster Y298C change.
SCAP P{UAS-SCAP.Y319C}1 8348 Expresses constitutively active SCAP with a Y319C amino acid change under UAS control. Y319C mimics the hamster Y298C change.
25.     Human stearyl-CoA desaturase 1/SCD1      Fly Desat1
Desat1 PBac{y[+]-attP-3B}VK00040 9755 This insertion (in the first intron) is uncharacterized but contains an attP docking site for phiC31 integrase-mediated transformation, 8/9/2010.
Desat1 P{TRiP.HMS01654}attP40 37512 Expresses dsRNA for RNAi of desat1 (FBgn0086687) under the control of UAS.
Desat1 P{TRiP.GL00428}attP2 35591 Expresses dsRNA for RNAi of desat1 (FBgn0086687) under the control of UAS.
Desat1 P{Desat1-GAL4.E800}4M 65407 Expresses GAL4 under the control of the desat1 promoter E region (nucleotides 83507-84375 in GenBank accession AC007594) in oenocytes in both males and females plus internal reproductive organs in males.
Desat1 P{Desat1-GAL4.E800}4M 65405 Expresses GAL4 under the control of the desat1 promoter E region (nucleotides 83507-84375 in GenBank accession AC007594) in oenocytes in both males and females plus internal reproductive organs in males.
Desat1 P{Desat1-GAL4.E800}2M 65406 Expresses GAL4 under the control of the desat1 promoter E region (nucleotides 83507-84375 in GenBank accession AC007594) in oenocytes in both males and females plus internal reproductive organs in males.
Desat1 P{Desat1-GAL4.E800}2M 65404 Expresses GAL4 under the control of the desat1 promoter E region (nucleotides 83507-84375 in GenBank accession AC007594) in oenocytes in both males and females plus internal reproductive organs in males.
Desat1 PBac{IT.GAL4}Desat1[1390-G4] 65700 May express GAL4 in some or all of the pattern of the Desat gene.
Desat1 PBac{IT.GAL4}Desat1[0832-G4] 63840 May express GAL4 in some or all of the pattern of the Desat gene.
Desat1 PBac{IT.GAL4}Desat1[0757-G4] 63500 May express GAL4 in some or all of the pattern of the Desat gene.
Desat1 PBac{IT.GAL4}Desat1[0243-G4] 64703 May express GAL4 in some or all of the pattern of the Desat gene.
26.     Human Sphingosine-1-phosphate lyase/SGPL1       Fly Sply
Sply P{PZ}Sply[05091] 11393 P{PZ} insertion in protein coding sequence (first or second exon depending on the transcript) causes loss of function
Sply Mi{MIC}Sply[MI15227] 60998 This Mi{MIC} is inserted in Sply coding sequence. It is uncharacterized but is an unverified lethal suggesting it may disrupt function.
Sply P{TRiP.HMS02684}attP40 43304 Expresses dsRNA for RNAi of Sply (FBgn0010591) under UAS control.
Sply P{TRiP.HMS02526}attP40 42834 Expresses dsRNA for RNAi of Sply (FBgn0010591) under UAS control.
27.     Human SLC25A1       Fly sea
sea P{EP}sea[EP3364] 17118 EP insertion in the first or second intron of sea (depending on the transcript) results a genetically null sea allele (insertion is also in intron of RC transcript of CG6783)
sea P{TRiP.HMS01163}attP2 34685 Expresses dsRNA for RNAi of fabp (FBgn0037913) and sea (FBgn0037912) under UAS control.
sea P{TRiP.HMS00936}attP2 33976 Expresses dsRNA for RNAi of sea (FBgn0037912) under the control of UAS.
28.     Human SLC25A4       Fly sesB
sesB sesB[9Ed-4] 8863 Hypomorphic allele.
sesB sesB[org] 27590 sesB mutant (amino acid change E266K)
sesB sesB[G0386] 12251 This P{lacW} inserted into the 1st intron likely disrupts sesB. Chromosome may carry an extraneous lethal.
sesB sesB[9Ed-1] 4687 sesB mutant (amino acid change A144T)
sesB sesB[G0247] 11959 This {lacW} insertion is uncharacterized but an unverified lethal (suggesting it may disrupt function). It could affect sesB or Ant2.
sesB sesB[G0126] 11830 This {lacW} insertion is uncharacterized but an unverified lethal (suggesting it may disrupt function). It could affect sesB or Ant2.
sesB P{TRiP.JF01810}attP2 31230 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.JF01528}attP2 31077 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.HMS01549}attP2 36661 Expresses dsRNA for RNAi of sesB (FBgn0003360) under the control of UAS.
sesB sesB[EY08924] 19943 This P{EP} insertion in the first intron is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP319] 10108 This P{EP} insertion just upstream of the transcription start is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1577] 11287 This P{EP} insertion just upstream of the transcription start or in the first intron (depending on the transcript) is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1393] 11286 This P{EP} insertion in the first intron is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
29.     Human SLC25A30      Fly Bmcp
Bmcp P{GT1}Bmcp[BG02446] 12688 Bmcp loss of function allele (GT1 insertion in the ATG translation start codon)
Bmcp P{TRiP.HMS01640}attP40 37498 Expresses dsRNA for RNAi of Bmcp (FBgn0036199) under the control of UAS.
30.     Human SREBP/SREBPF1      Fly SREBP
SREBP SREBP[189] 38393 Deletes 697 bp of the HLH106 coding region (up to amino acid 233) as well as the first exon of Gyc76C
SREBP HLH106[189], S2P[1] 38392 HLH106[189] (deletes 697 bp of the HLH106 coding region as well as the first exon of Gyc76C) and S2P[1] (deletes all of S2P and CG34229)
SREBP HLH106[189], P{UAS-HLH106.K}2 38396 Expresses wildtype HLH106 under the control of UAS in the presence of HLH106[189]
SREBP HLH106[189], P{UAS-HLH106.1-452}2 41018 Expresses truncated, constitutively active HLH106 (=SREBP) under UAS control in the presence of HLH106[189].
SREBP HLH106[189], P{GAL4-dSREBPg.K}A39 38395 Expresses SREBP with the transcription factor domain replaced by GAL4. GAL4-dependent gene expression via UAS is activated only after SREBP cleavage. HLH106[189] is in the background.
SREBP SREBP[1] 26178 HLH106 mutant (Q175stop)
SREBP PBac{y[+]-attP-9A}VK00021 9739 This insertion (in the first intron) is uncharacterized but contains an attP docking site for phiC31 integrase-mediated transformation, 8/9/2010.
SREBP P{TRiP.JF01997}attP2 25975 Expresses dsRNA for RNAi of HLH106 under UAS control.
SREBP P{TRiP.HMS00080}attP2 34073 Expresses dsRNA for RNAi of HLH106 (FBgn0261283) under the control of UAS.
SREBP P{UAS-SREBP.K}2, SREBP[189] 38396 Expresses wildtype HLH106 under the control of UAS in the presence of HLH106[189]
SREBP P{UAS-SREBP.Exel}3 8236 Expresses wild type HLH106 (=SREBP) under the control of UAS.
SREBP P{UAS-SREBP.Exel}1 8237 Expresses wild type HLH106 (=SREBP) under the control of UAS.
SREBP P{UAS-SREBP.P450}3 8245 Expresses a dominant negative HLH106 with an ER localization sequence appended to the C-terminus under the control of UAS.
SREBP P{UAS-SREBP.P450}2 8246 Expresses a dominant negative HLH106 with an ER localization sequence appended to the C-terminus under the control of UAS.
SREBP P{UAS-SREBP.P450}1 8247 Expresses a dominant negative HLH106 with an ER localization sequence appended to the C-terminus under the control of UAS.
SREBP P{UAS-SREBP.NTdel}3 8241 Expresses dominant negative HLH106 deleted for the highly acidic region at the N terminus (amino acids 1-75) and missing the transmembrane domains under the control of UAS.
SREBP P{UAS-SREBP.NTdel}1 8242 Expresses dominant negative HLH106 deleted for the highly acidic region at the N terminus (amino acids 1-75) and missing the transmembrane domains under the control of UAS.
SREBP P{UAS-SREBP.Ndel}3 8240 Expresses a dominant negative HLH106 deleted for the highly acidic region at the N terminus (amino acids 1-75) under the control of UAS.
SREBP P{UAS-SREBP.Ndel}2 8239 Expresses a dominant negative HLH106 deleted for the highly acidic region at the N terminus (amino acids 1-75) under the control of UAS.
SREBP P{UAS-SREBP.Ndel}1 8238 Expresses a dominant negative HLH106 deleted for the highly acidic region at the N terminus (amino acids 1-75) under the control of UAS.
SREBP P{UAS-SREBP.Cdel}2 8244 Expresses a constitutively active and nuclear localized HLH106 truncated right before the first transmembrane domain under the control of UAS.
SREBP P{UAS-SREBP.Cdel}1 8243 Expresses a constitutively active and nuclear localized HLH106 truncated right before the first transmembrane domain under the control of UAS.
SREBP P{UAS-SREBP.1-452}2 41018 Expresses truncated, constitutively active HLH106 (=SREBP) under UAS control.
SREBP P{UAS-SREBP.1-452}1 41017 Expresses truncated, constitutively active HLH106 (=SREBP) under UAS control.
SREBP P{GAL4-dSREBPg.K}B31 39612 Expresses SREBP with the transcription factor domain replaced by GAL4. GAL4-dependent gene expression via UAS is activated only after SREBP cleavage. A deletion for SCAP is in the background.
SREBP P{GAL4-dSREBPg.K}A45 38394 Expresses SREBP with the transcription factor domain replaced by GAL4. GAL4-dependent gene expression via UAS is activated only after SREBP cleavage.
SREBP P{GAL4-dSREBPg.K}A39, HLH106[189] 38395 Expresses SREBP with the transcription factor domain replaced by GAL4. GAL4-dependent gene expression via UAS is activated only after SREBP cleavage. HLH106[189] is in the background.
31.     Human TSC1       Fly Tsc1
Tsc1 Tsc1[1149] 63104 Tsc1 mutant
Tsc1 PBac{WH}Tsc1[f01910] 18488 This PBac{WH} in the 6th intron of Tsc1 disrupts Tsc1 function
Tsc1 P{TRiP.JF01484}attP2 31039 Expresses dsRNA for RNAi of Tsc1 under UAS control.
Tsc1 P{TRiP.JF01262}attP2 31314 Expresses dsRNA for RNAi of Tsc1 under UAS control.
Tsc1 P{TRiP.HMJ21477}attP40 54034 Expresses dsRNA for RNAi of Tsc1 (FBgn0026317) under UAS control.
Tsc1 P{TRiP.HMC03672}attP40 52931 Expresses dsRNA for RNAi of Tsc1 (FBgn0026317) under UAS control.
Tsc1 P{TRiP.GL00012}attP2 35144 Expresses dsRNA for RNAi of Tsc1 (FBgn0026317) under the control of UAS.
32.     Human TSC2       Fly gig
gig Mi{MIC}gig[MI14761] 59563 This Mi{MIC} insertion in a coding exon of gig is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
gig gig[109] 4739 EMS-induced allele of gig.
gig P{TRiP.HMS01217}attP2 34737 Expresses dsRNA for RNAi of gig (FBgn0005198) under the control of UAS.
gig P{TRiP.HM04083}attP2 31770 Expresses dsRNA for RNAi of gig under UAS control.
gig P{TRiP.GL00321}attP2 35401 Expresses dsRNA for RNAi of gig (FBgn0005198) under the control of UAS.