Stock Center logo
Neurofibromatosis, Type I
Type I Neurofibromatosis is characterized by the growth of benign neurofibromas along nerves and changes in skin pigmentation. Other symptoms can include Lisch nodules in the iris, macrocephaly, high blood pressure, spine curvatures and malignant peripheral nerve sheath tumors.

General information links for Neurofibromatosis, Type I:
Genetics Home Reference
NLM/NIH's GeneReview
NLM/NIH's Genetic and Rare Disease Information Center
Causative genes for Neurofibromatosis, Type I
Syndrome Human gene Human full name Fly gene
Neurofibromatosis type I NF1 Neurofibromin I Nf1

Stocks for studying Neurofibromatosis, Type I
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
Nf1 PBac{PB}Nf1[c00617] 10201 This PBac{PB} insertion in the 8th intron causes memory defects.
Nf1 Mi{MIC}Nf1[MI01388] 34427 This Mi{MIC} is inserted in coding sequence in the 12th exon. It is uncharacterized but is an unverified lethal suggesting it may disrupt function.
Nf1 P{TRiP.JF01866}attP2 25845 Expresses dsRNA for RNAi of Nf1 (FBgn0015269) under UAS control.
Nf1 P{TRiP.JF01767}attP2 31466 Expresses dsRNA for RNAi of Nf1 (FBgn0015269) under UAS control.
Nf1 P{TRiP.HMC03551}attP40 53322 Expresses dsRNA for RNAi of Nf1 (FBgn0015269) under UAS control.