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Parkinson disease
Parkinson disease is a progressive neurological disorder resulting from the loss of dopaminergic neurons in the midbrain (largely in the substantia nigra). Symptoms include tremor, loss of balance and motor coordination, rigidity, and slowing of movements. Fly stocks in the Bloomington collection that can be used to study Parkinson disease are listed here.

General information links for Parkinson disease:
OMIM links to Parkinson subtypes are listed in the table below
NIH's Genetics Home Reference - includes links for GHR pages for several of the genes below
NLM/NIH's Genetic and Rare Disease Information Center
Parkinson subtypes with causative genes identified (from OMIM)
subtype Human gene symbol Human gene full name Fly gene
PARK1 and PARK4 SNCA alpha-synuclein  
PARK2 PARK2 Parkin parkin (park)
PARK6 PINK1 PINK1 PTEN-induced putative kinase 1 (Pink1)
PARK7 DJ1/PARK7 DJ1 DJ-1alpha and dj-1beta
PARK8 LRRK2 Leucine-rich repeat kinase 2/dardarin Leucine-rich repeat kinase (Lrrk)
PARK13 HTRA2 HTRA2 HtrA2
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
PARK1 and 4      Human alpha-synuclein
alpha-synuclein (human) P{UAS-SNCA.J}7 51376 Expresses insect codon-optimized human alpha-synuclein (SNCA) under the control of UAS.
alpha-synuclein (human) P{UAS-SNCA.J}4 51374 Expresses insect codon-optimized human alpha-synuclein (SNCA) under the control of UAS.
alpha-synuclein (human) P{UAS-SNCA.J}1 51375 Expresses insect codon-optimized human alpha-synuclein (SNCA) under the control of UAS.
alpha-synuclein (human) P{UAS-HsapSNCA.F}5B 8146 Expresses wild type human alpha-synuclein under UAS control
alpha-synuclein (human) P{UAS-HsapSNCA.A53T}15.3 8148 Expresses human mutant A53T form of alpha-synuclein under UAS control
alpha-synuclein (human) P{UAS-HsapSNCA.A30P}40.1 8147 Expresses human mutant A30P form of alpha-synuclein under UAS control
PARK2      Human Parkin       Fly parkin
parkin park[Delta21] 51652 Deletion of park from just 5prime of the translational start to approximately 1 kb 3prime.
parkin PBac{PB}park[c00062] 10006 Drosophila Parkin mutant (PB insertion into the 3rd intron)
parkin park[1] 34747 Hemizygous males may be present. Balancer contains unknown GFP-containing construct
parkin P{TRiP.JF01200}attP2 31259 Expresses dsRNA for RNAi of park under UAS control.
parkin P{TRiP.HMS01800}attP2 38333 Expresses dsRNA for RNAi of park (FBgn0041100) under the control of UAS.
parkin P{TRiP.HMS01651}attP40 37509 Expresses dsRNA for RNAi of park (FBgn0041100) under the control of UAS.
parkin P{UAS-park.G}L2 51651 Expresses park under UAS control.
parkin P{UAS-park.MYC.T187A}2 34748 Expresses myc-tagged park with a T187A mutation (T187 corresponds to human T175 which is phosphorylated by PINK1)
parkin P{UAS-park.FLAG.COX-IV}3 34746 Expresses FLAG-tagged mitochondrial-localized park under the control of UAS
PARK6      Human Pink1       Fly Pink1
Pink1 Pink1[5] 51649 Deletion of Pink1 sequences including the mitochondrial targeting sequences and 70% of the kinase domain.
Pink1 Pink1[B9] 34749 Pink1 loss of function allele (imprecise excision of a P{EP} resulting in a 570 bp deletion of Pink1 sequences)
Pink1 P{TRiP.JF01672}attP2 31170 Expresses dsRNA for RNAi of Pink1 under UAS control.
Pink1 P{TRiP.JF01203}attP2 31262 Expresses dsRNA for RNAi of Pink1 under UAS control.
Pink1 P{TRiP.HMS02204}attP2 41671 Expresses dsRNA for RNAi of Pink1 (FBgn0029891) under UAS control.
Pink1 P{TRiP.HMS01707}attP40 38262 Expresses dsRNA for RNAi of Pink1 (FBgn0029891) under the control of UAS.
Pink1 P{TRiP.HMC04160}attP2 55886 Expresses dsRNA for RNAi of Pink1 (FBgn0029891) under UAS control.
Pink1 P{UAS-Pink1.C}A 51648 Expresses Pink1 under UAS control.
PARK7      Human DJ1       Fly DJ-1alpha and dj-1beta
DJ-1a & dj-1b DJ-1alpha[Delta72]; dj-1beta[Delta93] 33602 Deletion of both the DJ-1alpha and dj-1beta coding sequences.
DJ-1alpha DJ-1alpha[Delta72] 33600 Deletion of the DJ-1alpha coding sequence.
DJ-1alpha P{TRiP.JF01201}attP2 31260 Expresses dsRNA for RNAi of DJ-1alpha under UAS control.
DJ-1alpha P{TRiP.HMS01975}attP40 39055 Expresses dsRNA for RNAi of DJ-1alpha (FBgn0033885) under UAS control.
DJ-1alpha P{TRiP.HMS01797}attP2 38330 Expresses dsRNA for RNAi of DJ-1alpha (FBgn0033885) under the control of UAS.
DJ-1alpha P{TRiP.HMJ21180}attP40 51177 Expresses dsRNA for RNAi of DJ-1alpha (FBgn0033885) under UAS control.
DJ-1alpha P{UAS-DJ-1alpha.M}2 33603 Expresses DJ-1alpha under the control of UAS.
dj-1beta dj-1beta[Delta93] 33601 Deletion of the dj-1beta coding sequence.
dj-1beta PBac{5HPw[+]}dj-1beta[A286] 16085 dj-1beta mutation (5HPw+ insertion into the 3rd exon)
dj-1beta P{TRiP.JF01202}attP2 31261 Expresses dsRNA for RNAi of dj-1beta under UAS control.
dj-1beta P{TRiP.HMS01915}attP2 38999 Expresses dsRNA for RNAi of dj-1beta (FBgn0039802) under UAS control.
dj-1beta P{TRiP.HMS01847}attP40 38378 Expresses dsRNA for RNAi of dj-1beta (FBgn0039802) under the control of UAS.
dj-1beta P{UAS-dj-1beta.M}7 33604 Expresses dj-1beta under the control of UAS.
PARK8      Human LRRK2      Fly Lrrk
Lrrk Lrrk[ex1] 34750 Imprecise excision of a P{EP} resulting in a 464 bp deletion including the Lrrk stop codon
Lrrk P{TRiP.HMS01937}attP40 39019 Expresses dsRNA for RNAi of Lrrk (FBgn0038816) under UAS control.
Lrrk P{TRiP.HMS00456}attP2 32457 Expresses double-strand RNA for RNAi of Lrrk under the control of UAS.
Lrrk P{TRiP.GL00136}attP2 35249 Expresses double-strand RNA for RNAi of Lrrk under the control of UAS.
PARK13      Human HTRA2      Fly Htra2
HtrA2 P{TRiP.HMC03843}attP40 55165 Expresses dsRNA for RNAi of HtrA2 (FBgn0038233) under UAS control.
HtrA2 P{TRiP.HM05030}attP2 28544 Expresses double-strand RNA for RNAi of Htra2 under the control of UAS.