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Spinocerebellar ataxia type 1
Spinocerebellar ataxia type 1 (SCA1) is a progressive disorder characterized by loss of motor coordination and balance accompanied by other neurodegenerative problems including speech and swallowing issues, muscle stiffness/weakness and eventual muscle atrophy, cognitive impairments, and dementia. SCA1 is one of several diseases caused by an increase in the number of CAG repeats within the coding region of the disease gene (in this case the Ataxin 1/ATXN1 gene). Fly stocks in the Bloomington collection that can be used to study SCA1 are listed here.

General Information links for Spinocerebellar ataxia type 1:
OMIM
NCBI's GeneReviews
National Library of Medicine's Genetic Home Reference
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Fly Atx-1  and  Human ATXN1
Atx-1 P{UAS-Atx-1.T}MBR 39741 Expresses wildtype fly Atx-1 under the control of UAS
ATXN1 (human) P{UAS-HsapATX1.30Q}F6 39739 Expresses human Ataxin 1 with the normal number (30) of CAG repeats under the control of UAS.
ATXN1 (human) P{UAS-HsapATX1.82Q}M6 33818 Expresses human Ataxin1 (ATX1 or SCA1) with a long polyQ (glutamine) repeat of 82 amino acids under the control of UAS.
ATXN1 (human) P{UAS-HsapATX1.82Q}F7 39740 Expresses human Ataxin 1 with an expanded number (82) of CAG repeats under the control of UAS.
ATXN1 (human) P{UAS-HsapATX1.2Q}F5 39738 Expresses human Ataxin 1 with 2 CAG repeats under the control of UAS.
      general polyglutamine (polyQ)-containing stocks
20 Qs P{UAS-ZzzzCAG.20Q}3 30549 Expresses a C-terminally HA-tagged 20 amino acid polyglutamine tract flanked N-terminally by 8 non-glutamine aa and C-terminally by 13 non-glutamine aa under UAS control.
41 Qs P{UAS-41Q.HA}3 30540 Expresses a C-terminally HA-tagged 41 amino acid polyglutamine tract under UAS control.
48 Qs P{UAS-Q48.myc/flag}42 51674 Expresses 48 glutamines tagged with FLAG and Myc.
63 Qs P{UAS-ZzzzCAG.63Q}2 30544 Expresses a C-terminally HA-tagged 63 amino acid polyglutamine tract under UAS control.