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Spinocerebellar Ataxia 2
Spinocerebellar Ataxia 2 (SCA2) is a progressive disorder associated with loss of motor coordination, impaired eye movement and mild dementia. SCA2 is one of several diseases caused by an increase in the number of CAG repeats within the coding region of the disease gene (in this case the ataxin 2/ATXN2 gene) and subsequent translation of those repeats into an expanded polyglutamine (polyQ) tract in the protein. Fly stocks in the Bloomington collection that can be used to study SCA2 are listed here.

General information links for SCA2:
NIH's Genetic and Rare Diseases Information Center

General information links for ataxin 2:
NLM/NIH's Genetics Home Reference
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human ATXN2       Fly Atx2
Atx2 P{PZ}Atx2[06490] 11688 Atx2 loss of function allele (PZ insertion into 5'UTR)
Atx2 P{wHy}Atx2[DG08112] 21645 This P{wHy} insertion (in the 5' UTR) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/9/2010.
Atx2 P{TRiP.HMS02726}attP40 44012 Expresses dsRNA for RNAi of Atx2 (FBgn0041188) under UAS control.
Atx2 P{TRiP.HMS01392}attP2 36114 Expresses dsRNA for RNAi of Atx2 (FBgn0041188) under the control of UAS.
      general polyglutamine (polyQ)-containing stocks
20 Qs P{UAS-ZzzzCAG.20Q}3 30549 Expresses a C-terminally HA-tagged 20 amino acid polyglutamine tract flanked N-terminally by 8 non-glutamine aa and C-terminally by 13 non-glutamine aa under UAS control.
41 Qs P{UAS-41Q.HA}3 30540 Expresses a C-terminally HA-tagged 41 amino acid polyglutamine tract under UAS control.
48 Qs P{UAS-Q48.myc/flag}42 51674 Expresses 48 glutamines tagged with FLAG and Myc.
63 Qs P{UAS-ZzzzCAG.63Q}2 30544 Expresses a C-terminally HA-tagged 63 amino acid polyglutamine tract under UAS control.