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Machado-Joseph Disease
Machado-Joseph Disease (MJD, aka Spinocerebellar Ataxia 3 or SCA3) is a progressive disorder characterized by loss of motor coordination, spasticity, and impaired eye movements. MJD is one of several diseases caused by an increase in the number of CAG repeats within the coding region of the disease gene (in this case the ataxin-3/MJD gene) and subsequent translation of those repeats into an expanded polyglutamine (polyQ) tract in the protein. Fly stocks in the Bloomington collection that can be used to study MJD are listed here.

General Information links for Machado-Joseph disease:
OMIM
NLM/NIH's Genetic and Rare Disease Information Center

General information links for ataxin 3:
NIH's Genetics Home Reference"
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human ataxin-3 (ATXN3)
ATXN3 (human, aka MJD) P{UAS-SCA3.fl-Q27.myc}46.2 33609 Expresses N-terminally myc-tagged full length human Ataxin3 (MJD or SCA3) with a normal polyQ repeat of 27 amino acids.
ATXN3 (human, aka MJD) P{UAS-HsapMJD.tr-Q27}N18.3d 8149 Expresses a HA-tagged C-terminal fragment of the human Ataxin3 (MJD or SCA3) protein with a normal 27 repeat polyglutamine tract.
ATXN3 (human, aka MJD) P{UAS-ATXN3.CAG14.HisMycHA}02 40537 Expresses human Ataxin3 (MJD or SCA3) with a wildtype stretch of 14 CAG repeats under the control of UAS. Each reading frame is tagged with a different tag [His(-1), Myc(0), HA(+1)].
ATXN3 (human, aka MJD) P{UAS-SCA3.fl-Q84.myc}7.2 33610 Expresses N-terminally myc-tagged full length human Ataxin3 (MJD or SCA3) with a long polyQ repeat of 84 amino acids.
ATXN3 (human, aka MJD) P{UAS-HsapMJD.tr-Q78}c37.3 8141 Expresses a HA-tagged C-terminal fragment of the human Ataxin3 (MJD or SCA3) protein with 78 repeat polyglutamine tract); weakly expressed line causing mild degeneration phenotype.
ATXN3 (human, aka MJD) P{UAS-HsapMJD.tr-Q78}c211.2 8150 Expresses a HA-tagged C-terminal fragment of the human Ataxin3 (MJD or SCA3) protein with a 78 repeat polyglutamine tract; strongly expressed line causing severe degeneration phenotype.
ATXN3 (human, aka MJD) P{UAS-ATXN3.STOP.CAG94.HAMycHis}01 40536 Expresses human Ataxin3 (MJD or SCA3) with an expanded stretch of 94 CAG repeats preceded by a stop codon under the control of UAS. Each reading frame is tagged with a different tag [HA(-1), Myc(0), His (+1)].
ATXN3 (human, aka MJD) P{UAS-ATXN3.STOP.CAA94.HAMycHis}01 39758 Expresses human Ataxin3 (MJD or SCA3) with an expanded stretch of 94 CAA repeats preceded by a stop codon under the control of UAS. Each reading frame is tagged with a different tag [HA(-1), Myc(0), His (+1)].
ATXN3 (human, aka MJD) P{UAS-ATXN3.CAG89.HisMycHA}02 39757 Expresses human Ataxin3 (MJD or SCA3) with an expanded stretch of 89 CAG repeats under the control of UAS. Each reading frame is tagged with a different tag [His(-1), Myc(0), HA(+1)].
ATXN3 (human, aka MJD) P{UAS-ATXN3.CAG89.HAMycHis}01 40535 Expresses human Ataxin3 (MJD or SCA3) with an expanded stretch of 89 CAG repeats under the control of UAS. Each reading frame is tagged with a different tag [HA(-1), Myc(0), His (+1)].
ATXN3 (human, aka MJD) P{UAS-ATXN3.CAA91.HisMycHA}02 39756 Expresses tagged human Ataxin3 (MJD or SCA3) with an expanded stretch of 91 CAA repeats under the control of UAS. Each reading frame is tagged with a different tag [His(-1), Myc(0), HA(+1)].
      general polyglutamine (polyQ)-containing stocks
20 Qs P{UAS-ZzzzCAG.20Q}3 30549 Expresses a C-terminally HA-tagged 20 amino acid polyglutamine tract flanked N-terminally by 8 non-glutamine aa and C-terminally by 13 non-glutamine aa under UAS control.
41 Qs P{UAS-41Q.HA}3 30540 Expresses a C-terminally HA-tagged 41 amino acid polyglutamine tract under UAS control.
48 Qs P{UAS-Q48.myc/flag}42 51674 Expresses 48 glutamines tagged with FLAG and Myc.
63 Qs P{UAS-ZzzzCAG.63Q}2 30544 Expresses a C-terminally HA-tagged 63 amino acid polyglutamine tract under UAS control.