Stock Center logo
Spinal Muscular Atrophy
Spinal Muscular Atrophy (SMA) is a neuromuscular disease characterized by the degeneration of spinal cord motor neurons and subsequent muscle atrophy. Four types of SMA (types I thru IV) are caused by loss of the SMN1 gene. These four forms primarily differ in time of onset and severity, type I being the most severe and type IV the mildest. Which form the disease takes may be determined by the number of SMN2 genes present (see the Genetics Home Reference for more information). Fly stocks in the Bloomington collection that can be used to study SMA are listed here.

General Information links for SMA:
NIH's Genetics Home Reference - includes links for GHR pages on SMN1 and SMN2
NLM/NIH's Genetic and Rare Disease Information Center
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human SMN1 and SMN2       Fly Smn
Smn Smn[73Ao] 4802 Smn loss of function mutation, G202S.
Smn PBac{WH}Smn[f05960] 18923 Smn strong hypomorphic allele (WH insertion at amino acid K136)
Smn P{TRiP.JF02057}attP2 26288 Expresses double-strand RNA for RNAi of Smn.
Smn P{TRiP.HMC03832}attP40 55158 Expresses dsRNA for RNAi of Smn (FBgn0036641) under UAS control.
Smn P{TRiP.GL00581}attP2 36621 Expresses dsRNA for RNAi of Smn (FBgn0036641) under the control of UAS.