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Werner syndrome
Werner syndrome is a disorder characterized by accelerated symptoms of aging including graying of hair, diabetes, cardiovascular disease, sarcomas, atherosclerosis, and cataracts. Werner syndrome is caused by mutations in the DNA helicase gene, RecQ (aka WRN), which are believed to lead to hyper-recombination and DNA replication defects. Fly stocks in the Bloomington collection that can be used to study Werner syndrome are listed here.

General Information links for Werner syndrome:
NIH's Genetics Home Reference - includes links for a GHR page on WRN
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Human WRN/RECQL2 (RecQ protein-like 2)       Fly WRNexo
WRNexo PBac{RB}WRNexo[e04496] 18267 PBac{RB} insertion in the 5' UTR results in extremely low transcript levels
WRNexo P{TRiP.HMS01758}attP40 38297 Expresses dsRNA for RNAi of WRNexo (FBgn0038608) under the control of UAS.