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Cardiovascular Diseases
Cardiovascular diseases are the leading cause of death worldwide as well as a major cause of disability. Forms of cardiovascular disease include cardiomyopathies, cardiac dysrhythmias, hypertension, inflammatory diseases, congenital disorders and more. Drosophila is used both as a model to understand inherited disorders and risk factors as well as to study the mechanistic basis of cardiovascular disease associated with metabolic changes due to obesity, diabetes and ageing.

General information links for cardiovascular diseases:
OMIM links for various disorders can be navigated to via the links under the human genes in the first table
Global cardiovascular disease facts from the World Health Organization.
Genetics Home Reference - search for specific conditions or browse lists
Genes of interest for Cardiac diseases
Human gene Human protein Fly gene Comments
ABCC9 (SUR2) ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Sur see FBrf0201972
ACE Angiotensin I-converting enzyme Ance
ACTA2 Actin, alpha-2, smooth muscle Act87E Act87E is expressed in adult, but not larval, cardiac tissue, FBrf0213326.
ACTC1 Actin, alpha, cardiac muscle Act57B Act57B is expressed in both larval and adult cardiac tissue, FBrf0213326.
ACTN2 Actinin, alpha-2 Actn
ANK2 Ankyrin 2 Ank2
ANK2 Ankyrin 2 Ank
ATP2A2 ATPase, Ca(2+)-transporting, slow-twitch (aka SERCA2) Ca-P60A Ca-P60A is similarly related to ATP2A1
BAG3 BCL2-associated athanogene 3 ??
CACNA1A Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit cac see FBrf0210524
CACNA1C Calcium channel, voltage-dependent, L type, alpha 1C subunit Ca-alpha1D
CACNA1E Calcium channel, voltage-dependent, alpha-1E subunit cac see FBrf0210524
CALR3 calreticulin 3 Crc
CAV3 caveolin 3 none
COX15 cytochrome c oxidase assembly homolog 15 CG3803
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) Mlp60A
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) Mlp84B see FBrf0202432
DES Desmin ??
DMD dystrophin Dys
DSG2 desmoglein 2 ??
DSG2 desmoglein 2 ??
DTNA Dystrobrevin, alpha Dyb
EYA4 eyes absent 4 eya
FGFR FGF receptor htl
FLNA filamin A, alpha cher
GATA4 GATA-binding protein 4 pnr see FBrf0218172
GATA6 GATA-binding protein 6 pnr see FBrf0218172
GATAD1 GATA zinc finger domain containing 1 CG13367
GNB3 Guanine nucleotide-binding protein, beta-3 Gbeta13F see FBrf0211718
Hand1 heart and neural crest derivatives expressed 1 Hand
Hand2 heart and neural crest derivatives expressed 2 Hand
HSD11B2 11-beta-hydroxysteroid dehydrogenase type II ??
JPH2 junctophilin 2 jp
KCNH2 Potassium channel, voltage gated, subfamily H, member 2 sei
KCNQ1 Potassium Channel, Voltage-gated, Shaker-related Subfamily, Member 9 KCNQ
LDB3 Lim domain-binding 3 Zasp52
LMNA Lamin A/C LamC
LMNA Lamin A/C Lam
MYBPC3 Myosin-binding protein C, cardiac ??
MYH10 Myosin, heavy chain 10, nonmuscle zip
MYH11 Myosin, heavy chain 11, smooth muscle zip
MYH6 Myosin, heavy chain 6, cardiac muscle, alpha Mhc MHC is sole myosin heavy chain in flies
MYH7 Myosin, heavy chain 7, cardiac muscle, beta Mhc MHC is sole myosin heavy chain in flies
MYL2 Myosin, light chain 2, regulatory, cardiac, slow Mlc2 Mlc2 is sole muscle regulatory light chain in flies
MYL3 Myosin, light chain 3, alkali; ventricular, skeletal, slow Mlc1 Mlc1 is sole muscle essential light chain in flies
MYLK2 Myosin light chain kinase 2 sqa
MYLK2 Myosin light chain kinase 2 Strn-Mlck
NEXN Nexilin, rat, homolog of ??
NKX2-5 NK2 homeobox 5 tin
NOS3 nitric oxide synthase Nos
NPPA natriuretic peptide precursor A ??
NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide recep C) CG14877?
PON1 paraoxonase-1 ??
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit SNF4Agamma
PSEN1 Presenilin 1 Psn
PSEN2 Presenilin 2 Psn
RYR2 Ryanodine receptor 2 RyR
SCN5A Sodium channel, voltage gated, type V, alpha subunit para?
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) SdhA
SELE Selectin E ??
SGCD Sarcoglycan, Delta Scgdelta
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 sesB
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 Ant2
SNTA1 Syntrophin, alpha-1 Syn1
SNTB2 Syntrophin, beta-2 Syn1
TAZ Tafazzin Taz
TBX20 T-box 20 H15
TBX20 T-box 20 mid
Tbx5 T-box 5 Doc2 FBrf0210227 reports that Doc1, Doc2 and Doc3 may be redundant genes
Tbx5 T-box 5 Doc3 FBrf0210227 reports that Doc1, Doc2 and Doc3 may be redundant genes
Tbx5 T-box 5 Doc1 FBrf0210227 reports that Doc1, Doc2 and Doc3 may be redundant genes
TNNC1 troponin C TpnC73F see FBrf0174641 for TpnC family expression patterns
TNNC1 troponin C TpnC47D see FBrf0174641 for TpnC family expression patterns
TNNC1 troponin C TpnC4 see FBrf0174641 for TpnC family expression patterns
TNNC1 troponin C TpnC41C see FBrf0174641 for TpnC family expression patterns
TNNC1 troponin C TpnC25D see FBrf0174641 for TpnC family expression patterns
TNNI3 Troponin I wupA
TNNT2 Troponin T2, cardiac up
TPM1 Tropomyosin 1 Tm1
TPM1 Tropomyosin 1 Tm2
TTN Titin bt
TTN Titin sls
VCL Vinculin Vinc

Stocks for studying cardiac diseases
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
Act57B P{TRiP.JF01113}attP2 31551 Expresses dsRNA for RNAi of Act57B (FBgn0000044) under UAS control.
Act57B P{UASp-GFP.Act57B}6-3 9256 Expresses GFP-tagged Act57B under the control of UAS.
Act57B P{UASp-GFP.Act57B}10-2 9255 Expresses GFP-tagged Act57B under the control of UAS.
Act87E P{TRiP.HMS02488}attP2 42652 Expresses dsRNA for RNAi of Act87E (FBgn0000046) under UAS control.
Act87E P{UASp-GFP.Act87E}7-6 9249 Expresses GFP-tagged Act87E under the control of UAS.
Act87E P{UASp-GFP.Act87E}12-1 9250 Expresses GFP-tagged Act87E under the control of UAS.
Actn Actn[8] 4654 Null Actn allele caused by an inversion separating the promoter and first 38 codons from the rest of the gene.
Actn Actn[1] 32001 An EMS point mutation resulting in temperature sensitive locomoter defects.
Actn Actn[14] 4655 An EMS mutation in Actn
Actn P{TRiP.HMS00193}attP2 34874 Expresses dsRNA for RNAi of Actn (FBgn0000667) under UAS control.
Actn P{PTT-GC}Actn[CC01961] 51573 GFP protein trap in Actn.
Ance Ance[34Eb-2] 3584 An EMS-generated Ance mutation.
Ance P{TRiP.HMS03009}attP2 36749 Expresses dsRNA for RNAi of Ance (FBgn0012037) under UAS control.
Ance P{TRiP.GLC01369}attP2 51394 Expresses dsRNA for RNAi of Ance (FBgn0012037) under UAS control.
Ance Mi{PT-GFSTF.1}Ance[MI05748-GFSTF.1] 59828 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Ance tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Ank P{TRiP.JF01588}attP2 31115 Expresses dsRNA for RNAi of Ank (FBgn0011747) under UAS control.
Ank P{TRiP.GL01575}attP2 43965 Expresses dsRNA for RNAi of Ank (FBgn0011747) under UAS control.
Ank2 Mi{MIC}Ank2[MI06602] 60798 Uncharacterized insertion but is an unverified semi-lethal suggesting it may disrupt function.
Ank2 P{TRiP.JF03374}attP2 29438 Expresses dsRNA for RNAi of Ank2 (FBgn0085445) under UAS control.
Ank2 P{TRiP.HMS00295}attP2 33414 Expresses dsRNA for RNAi of Ank2 (FBgn0085445) under UAS control.
Ank2 PBac{WH}Ank2[f02001] 18502 This PBac{WH} insertion is in the last coding exon of Ank2 (as well as in the last non-coding exon of CG44195). It causes lethality and neuronal defects.
Ant2 P{lacW}Ant2[G0126] 11830 P{lacW} insertion in a non-coding exon of sesB and intron of Ant2. It is an unverified lethal suggesting it affects either sesB or Ant2.
bt bt[1] 640 bt mutation, temperature sensitive
bt bt[1] 636 bt mutation, temperature sensitive
bt bt[l-k] 4467 bt mutant caused by X-ray mutagenesis
bt bt[l-b] 4231 bt mutant caused by X-ray mutagenesis
bt bt[D] 638 dominant bt mutant caused by X-ray mutagenesis
bt P{TRiP.JF01108}attP2 31546 Expresses dsRNA for RNAi of bt (FBgn0005666) under UAS control
bt P{TRiP.JF01107}attP2 31545 Expresses dsRNA for RNAi of bt (FBgn0005666) under UAS control
cac cac[HC129] 8579 X-ray induced loss of function allele.
cac cac[K] 57064 An allele of cac (aa change W623stop)
cac cac[J] 67176 Harbors an EMS-induced L284term mutation in the cac gene.
cac cac[HF368] 965 Deletion of the 5' region of the gene.
cac cac[H18] 42245 Change of W to stop in one of the alternative ninth cac exons so only affects some isoforms. Phenotypes may be restricted to visual system.
cac cac[F] 67175 Harbors an EMS-induced E989K mutation in the cac gene.
cac P{TRiP.JF02572}attP2 27244 Expresses dsRNA for RNAi of cac (FBgn0005563) under UAS control.
cac P{UAS-cac1-EGFP}786C 8581 Expresses the cacophony alpha1 subunit with EGFP appended to the C-terminus under the control of UAS.
cac P{UAS-cac1-EGFP}471 8580 Expresses the cacophony alpha1 subunit with EGFP appended to the C-terminus under the control of UAS.
cac P{UAS-cac1-EGFP}422A 8582 Expresses the cacophony alpha1 subunit with EGFP appended to the C-terminus under the control of UAS.
cac Mi{FlpStop}cac[MI02836-FlpStop.ND] 67681 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion has introduced a FlpStop cassette in the non-disrupting (ND) orientation (see Fisher et al., 2017. eLife. Feb 17).
cac Mi{Trojan-GAL4.0}cac[MI02836-TG4.0] 67444 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of cac regulatory sequences.
cac Mi{Trojan-GAL4DBD.0}cac[MI02836-TG4DBD.0] 60335 Expresses a GAL4 DNA binding domain-leucine zipper fusion protein under the control of cac regulatory sequences.
Calr P{PTT-GA}Calr[CA06507] 50795 This P{PTT-GA} insertion in the second intron acts as a protein trap.
Calr P{ST.lexA::HG}Calr[ML-3] 66622 Expresses lexA in the ring gland, corpora cardiaca cells (ring gland), and salivary gland under the control of Calr.
Calr P{lacW}Calr[S114307] 4545 This P{lacW} insertion in 5' UTR is associated with neurological defects.
Calr P{lacW}Calr[S062111] 37724 This P{lacW} insertion into the second intron is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
CG3803 PBac{WH}CG3803[f04773] 18804 This PBac{WH} insertion into the noncoding portion of the first exon is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
CG3803 P{TRiP.JF01524}attP2 31073 Expresses dsRNA for RNAi of CG3803 under UAS control.
CG3803 P{TRiP.JF01523}attP2 31072 Expresses dsRNA for RNAi of CG3803 under UAS control.
CG3803 P{TRiP.HMS02641}attP40 42948 Expresses dsRNA for RNAi of CG3803 (FBgn0034938) under UAS control.
CG3803 P{TRiP.HMS01473}attP2 35731 Expresses dsRNA for RNAi of CG3803 (FBgn0034938) under UAS control.
cher P{TRiP.JF02077}attP2 26307 Expresses dsRNA for RNAi of cher (FBgn0014141) under UAS control.
cher P{TRiP.HMS01501}attP2 35755 Expresses dsRNA for RNAi of cher (FBgn0014141) under UAS control.
cher Mi{PT-GFSTF.0}cher[MI07480-GFSTF.0] 60261 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of cher tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Doc1 Mi{ET1}Doc1[MB02443] 23568 This M{ET1} insertion into the first or second intron (depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Doc1 P{TRiP.JF02222}attP2 31931 Expresses dsRNA for RNAi of Doc1 (FBgn0028789) under UAS control.
Doc2 P{TRiP.HMS02804}attP2 44087 Expresses dsRNA for RNAi of Doc2 (FBgn0035956) under UAS control.
Doc3 P{TRiP.JF02223}attP2 31932 Expresses dsRNA for RNAi of Doc3 (FBgn0035954) under UAS control.
Doc3 P{TRiP.HMJ24017}attP40 62493 Expresses dsRNA for RNAi of Doc3 (FBgn0035954) under UAS control.
Doc3 P{TRiP.HMJ23936}attP40 62456 Expresses dsRNA for RNAi of Doc3 and mid (FBgn0035954 and FBgn0261963) under UAS control.
Doc3 P{TRiP.HMC05802}attP2 64929 Expresses dsRNA for RNAi of Doc3 (FBgn0035954) under UAS control.
Dys Dys[E17] 63047 Dys hypomoprphic allele
Dys Dys[det-1] 63046 Dys hypomoprphic allele
Dys Mi{MIC}Dys[MI01893] 37029 This Mi{MIC} insertion is in an intron but is an unverified lethal suggesting it may disrupt function.
Dys Mi{ET1}Dys[MB02524] 24182 This Mi{ET1} insertion is in coding sequence but is viable. It is unknown if function is disrupted (but viable Dys alleles do exist).
Dys P{TRiP.JF01118}attP2 31553 Expresses dsRNA for RNAi of Dys (FBgn0260003) under UAS control
Dys P{TRiP.HMC03789}attP40 55641 Expresses dsRNA for RNAi of Dys (FBgn0260003) under UAS control.
Dys Mi{PT-GFSTF.0}Dys[MI01893-GFSTF.0] 59782 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Dys tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Dys P{EP}Dys[EP3397] 17121 P{EP} insertion in first intron (or in 5' UTR depending on the transcript) show Dys mutant phenotypes
eya eya[DeltaCRM] 67648 loss-of-function allele of eya
eya eya[cli-IID] 3280 Amino acid change Q335stop causes a loss of function allele.
eya eya[2] 2285 Mutation caused by a 322 bp deletion 581 bp upstream of the start site.
eya eya[1] 3631 Mutation caused by a 1.5 kb deletion upstream of the start site.
eya eya[1] 6336 Mutation caused by a 1.5 kb deletion upstream of the start site.
eya P{TRiP.JF03160}attP2 28733 Expresses dsRNA for RNAi of eya (FBgn0000320) under UAS control.
eya P{TRiP.HMS05716}attP40 67853 Expresses dsRNA for RNAi of eya (FBgn0000320) under UAS control.
eya P{TRiP.HMS04515}attP40 57314 Expresses dsRNA for RNAi of eya (FBgn0000320) under UAS control.
eya P{TRiP.GLV21090}attP2 35725 Expresses dsRNA for RNAi of eya (FBgn0000320) under UAS control.
eya P{UAS-eya.B.I}55.2 5676 Expresses eya type I under the control of UAS.
eya P{UAS-eya.B.II}14 5675 Expresses eya type II under the control of UAS.
eya P{GMR21A11-GAL4}attP2 49292 Expresses GAL4 under the control of DNA sequences in or near eya.
Gbeta13F P{SUPor-P}Gbeta13F[KG08410] 16469 This P{SUPor-P} insertion in the first intron is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Gbeta13F P{TRiP.JF01609}attP2 31134 Expresses dsRNA for RNAi of Gbeta13F (FBgn0001105) under UAS control.
Gbeta13F P{TRiP.HMS01455}attP2 35041 Expresses dsRNA for RNAi of Gbeta13F (FBgn0001105) under UAS control.
Hand P{TRiP.HM05188}attP2 28977 Expresses dsRNA for RNAi of Hand (FBgn0032209) under UAS control.
Hand PBac{Hand-GFP.FPTB}VK00033 65299 Expresses GFP-, FLAG-, PreScission-, TEV- and BLRP-tagged Hand protein.
Hand Mi{Trojan-GAL4.0}Hand[MI04106-TG4.0] 66795 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of Hand regulatory sequences.
KCNQ Mi{MIC}KCNQ[MI11120] 56127 This Mi{MIC} insertion in first intron of the KCNQ-RD transcript is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
KCNQ Mi{MIC}KCNQ[MI02971] 36053 This Mi{MIC} insertion in either the first intron or 5' UTR (depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
KCNQ P{TRiP.JF02562}attP2 27252 Expresses dsRNA for RNAi of KCNQ (FBgn0033494) under UAS control.
Lam Lam[K2] 25093 A loss of function allele results from a 4 bp insertion between G460 and A461 that causes a frameshift after aa 153.
Lam Lam[A25] 25092 A loss of function allele results from two small deletions that cause a frameshift after aa 611 and removal of the C-term CAAX box.
Lam Lam[sz18] 6392 An EMS allele
Lam P{TRiP.JF01389}attP2 31605 Expresses dsRNA for RNAi of Lam (FBgn0002525) under UAS control.
Lam P{TRiP.HMC04816}attP40 57501 Expresses dsRNA for RNAi of Lam (FBgn0002525) under UAS control.
Lam P{TRiP.GL00577}attP2 36617 Expresses dsRNA for RNAi of Lam (FBgn0002525) under UAS control.
Lam P{UAS-Lam.GFP}3-3 7376 Expresses GFP-tagged Lam under the control of UAS.
Lam P{UAS-Lam.GFP}3-2 7377 Expresses GFP-tagged Lam under the control of UAS.
Lam P{UAS-Lam.GFP}2-1 7378 Expresses GFP-tagged Lam under the control of UAS.
Lam P{UAS-Lam.GFP}1-9 7375 Expresses GFP-tagged Lam under the control of UAS.
Lam P{PZ}Lam[04643] 11384 A loss of function allele caused by an insertion of P{PZ} into the 5' region of Lam.
LamC Mi{MIC}LamC[MI05494] 60784 This Mi{MIC} insertion in fourth exon (coding) of LamC is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
LamC LamC[k11904] 11050 This P{lacW} insertion is likely lethal but could also be a ttk mutation.
LamC P{TRiP.JF01406}attP2 31621 Expresses dsRNA for RNAi of LamC (FBgn0010397) under UAS control
LamC P{PTT-GB}LamC[G00158] 35516 This P{PTT-GB}insertion in the first intron is uncharacterized but is a verified lethal (note it could also be ttk mutation and is in wrong orientation to be a protein trap for LamC)
LamC P{PTT-GB}LamC[G00158] 6837 This P{PTT-GB}insertion in the first intron is uncharacterized but is a verified lethal (note it could also be ttk mutation and is in wrong orientation to be a protein trap for LamC)
LamC P{PTT-GB}LamC[CB04957] 51528 This P{PTT-GB}insertion in the first intron acts as a protein trap.
Mhc Mhc[5] 1022 Antimorphic (dominant-negative) allele caused by aa change G200D near the base of loop 1.
Mhc Mi{MIC}Mhc[MI03941] 36951 This Mi{MIC} insertion in an intron of Mhc is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Mhc P{TRiP.JF02069}attP2 26299 Expresses dsRNA for RNAi of Mhc (FBgn0086783) under UAS control.
Mhc P{TRiP.HMS01471}attP2 35729 Expresses dsRNA for RNAi of Mhc (FBgn0086783) under UAS control.
Mhc Mi{PT-GFSTF.0}Mhc[MI03941-GFSTF.0] 59813 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Mhc tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Mhc PBac{HpaI-GFP.A}Mhc[YD0783] 50881 Putative protein trap for Mhc.
Mhc P{Mhc.GluRIIB.Myc}3 64259 Expresses GluRIIB under the control of Mhc.
Mhc P{Mhc.GluRIIA.Myc}2 64258 Expresses GluRIIA under the control of Mhc.
Mhc P{Mhc-RFP.F3-580}2 38464 Expresses RFP under the control of Mhc.
Mhc P{Mhc-GFP.F4-453}3 38463 Expresses GFP under the control of Mhc.
Mhc P{Mhc-GFP.F4-453}2 38462 Expresses GFP under the control of Mhc.
Mhc P{Mhc-tauGFP}2 38460 Expresses GFP-tagged tau (GFP is localized to microtubules) under the control of Mhc.
Mhc P{Mhc-tauGFP}1 53739 Expresses GFP-tagged tau (GFP is localized to microtubules) under the control of Mhc.
Mhc P{Mhc-tauGFP}1 53736 Expresses GFP-tagged tau (GFP is localized to microtubules) under the control of Mhc.
Mhc P{Mhc-GAL4.K}2 55133 Expresses GAL4 strongly in differentiated muscles from embryonic stages onward.
Mhc P{Mhc-GAL4.K}1 55132 Expresses GAL4 strongly in differentiated muscles from embryonic stages onward.
Mhc P{Mhc-GAL4.F3-580}2 38464 Expresses GAL4 under the control of Mhc.
Mhc P{Mhc-Switch.O}GSG314-2 43641 Expresses steroid-activated GAL4 under the control of Mhc.
Mhc P{Mhc-lacZ.H}85-21-2 5840 Expresses lacZ under the control of Mhc.
Mhc P{Mhc-lacZ.H}76-25-Y 5839 Expresses lacZ under the control of Mhc.
Mhc P{lacW}Mhc[k10423] 10995 This P{lacW} insertion upstream or in an intron of Mhc is a lethal allele of Mhc.
mid mid[2] 18 Loss of function allele caused by amino acid change Q361stop.
mid mid[1] 3086 Loss of function allele caused by amino acid change Q128stop.
mid mid[los1] 8789 Loss of function allele caused by a 22 bp deletion resulting in a frameshift to a stop codon at aa 350.
mid P{TRiP.HMJ23936}attP40 62456 Expresses dsRNA for RNAi of Doc3 and mid (FBgn0035954 and FBgn0261963) under UAS control.
mid P{TRiP.HMC03082}attP2 50681 Expresses dsRNA for RNAi of mid (FBgn0261963) under UAS control.
Mlc1 P{TRiP.JF02698}attP2 27547 Expresses dsRNA for RNAi of Mlc1 (FBgn0002772) under UAS control.
Mlc2 Mlc2[E38] 4416 Loss of function allele caused by a stop codon at aa 10.
Mlc2 P{TRiP.JF01106}attP2 31544 Expresses dsRNA for RNAi of Mlc2 (FBgn0002773) under UAS control.
Mlc2 P{TRiP.JF01104}attP2 31543 Expresses dsRNA for RNAi of Mlc2 (FBgn0002773) under UAS control.
Mlc2 P{TRiP.HMS01583}attP2 36694 Expresses dsRNA for RNAi of Mlc2 (FBgn0002773) under UAS control.
Mlc2 P{Mlc2[+]3.4}JW1-5.25 4416 Mlc2 genomic construct carrying all the coding sequence plus 700 bp of 5' flank and around 650 of 3' flank.
Mlp60A P{TRiP.JF03313}attP2 29381 Expresses dsRNA for RNAi of Mlp60A (FBgn0259209) under UAS control.
Mlp84B Mlp84B[y-37] 8644 P excision allele that presumably removes regulatory sequences for Mlp84B.
Mlp84B Mlp84B[y-30] 8643 P excision allele that presumably removes regulatory sequences for Mlp84B.
Mlp84B P{TRiP.JF01128}attP2 31558 Expresses dsRNA for RNAi of Mlp84B (FBgn0014863) under UAS control.
Mlp84B P{Mlp84B[+t10]}3 8632 A 10 kb genomic fragment surrounding Mlp84B rescues Mlp84B lethality.
Mlp84B P{Mlp84B-GFP}5A 66563 Carries a 10.5 kb genomic fragment (located in an intron of Alh) that includes the 7 kb Mlp84B transcription unit plus 2 kb 5' and 1.5 kb 3'. Mlp84B-GFP is a C-terminal GFP fusion construct (inserted in a BamHI site just before the stop codon).
Mlp84B P{Mlp84B-GFP.NLS}12-1 66565 Carries a 10.5 kb genomic fragment (located in an intron of Alh) that includes the 7 kb Mlp84B transcription unit plus 2 kb upstream and 1.5 kb downstream sequences. Mlp84B-GFP.NLS contains the large T-antigen nuclear localization sequence.
Mlp84B P{Mlp84B-GFP.NES}33A 66564 Carries a 10.5 kb genomic fragment (located in an intron of Alh) that includes the 7 kb Mlp84B transcription unit plus 2 kb upstream and 1.5 kb downstream sequences. Mlp84B-GFP.NES contains the nuclear export sequence from PKI.
Mlp84B Mlp84B[0457-G4] 63332 May express GAL4 in some or all of the pattern of the Mlp84B gene (may also express under the control of Alh).
Nos Nos[1] 56822 A loss of function Nos allele (W591stop).
Nos Mi{MIC}Nos[MI04716] 37843 This Mi{MIC} insertion in the first intron is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Nos P{TRiP.JF03220}attP2 28792 Expresses dsRNA for RNAi of Nos (FBgn0011676) under UAS control.
Nos P{TRiP.HMC03076}attP2 50675 Expresses dsRNA for RNAi of Nos (FBgn0011676) under UAS control.
Nos P{TRiP.GLC01867}attP40 57700 Expresses dsRNA for RNAi of Nos (FBgn0011676) under UAS control.
Nos Mi{PT-GFSTF.0}Nos[MI09718-GFSTF.0] 60278 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Nos tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Nos P{UAS-Nos.L}2, P{UAS-Nos.L}3 56830 Expresses Nos under UAS control.
Nos P{UAS-Nos.L}2 56823 Expresses Nos under UAS control.
Nos P{UAS-Nos.L}1 56829 Expresses Nos under UAS control.
Nos P{GMR53C05-lexA}attP40 61559 Expresses lexA under the control of DNA sequences in or near Nos.
pnr pnr[VX6] 6334 Null allele of pnr (deletion of all but nine aa).
pnr pnr[1] 3106 Loss of function allele caused by amino acid change W180@.
pnr pnr[V1] 36553 Hypomorphic allele of pnr.
pnr pnr[VX4] 36552 Antimorphic/gain of function allele caused by a deletion from bp 1729 to 1745 resulting in a frameshift and a truncated protein of 513 aa.
pnr P{TRiP.HMS01136}attP2 34659 Expresses dsRNA for RNAi of pnr (FBgn0003117) under UAS control.
pnr P{TRiP.HMS01082}attP2 33744 Expresses dsRNA for RNAi of pnr (FBgn0003117) under UAS control.
pnr P{TRiP.HMS00570}attP2 33697 Expresses dsRNA for RNAi of pnr (FBgn0003117) under UAS control.
pnr P{TRiP.HM05146}attP2 28935 Expresses dsRNA for RNAi of pnr (FBgn0003117) under UAS control.
pnr pnr[D1] 36551 Allele caused by a Cys to Tyr change in the N-terminal zinc finger.
pnr P{UAS-pnr.H}13 7223 Expresses pnr under the control of UAS.
pnr P{UAS-pnr.D4}2 36546 Expresses a dominant negative pnr protein under UAS control.
pnr P{GawB}pnr[MD237] 3039 Expresses GAL4 under the control of pnr.
RyR RyR[Y4452X] 5507 aa change Y4452@, likely a loss of function mutation
RyR RyR[Q3878X] 5501 aa change Q3878@, likely a loss of function mutation
RyR RyR[16] 6812 6 kb internal deletion
RyR P{TRiP.JF03381}attP2 29445 Expresses dsRNA for RNAi of Rya-r44F (FBgn0011286) under UAS control.
RyR P{TRiP.JF01101}attP2 31695 Expresses dsRNA for RNAi of Rya-r44F (FBgn0011286) under UAS control.
RyR P{TRiP.JF01100}attP2 31540 Expresses dsRNA for RNAi of Rya-r44F (FBgn0011286) under UAS control.
RyR P{TRiP.HMC06147}attP40 65885 Expresses dsRNA for RNAi of RyR (FBgn0011286) under UAS control.
RyR P{TRiP.HM05130}attP2 28919 Expresses dsRNA for RNAi of Rya-r44F (FBgn0011286) under UAS control.
RyR RyR[R4305C] 5504 aa change R4305C, likely a gain of function mutation
RyR RyR[P2773L] 6537 aa change P2773L, likely a gain of function mutation
RyR RyR[E4340K] 5505 Gain of function allele caused by aa change E4340K
RyR P{EPgy2}RyR[EY12439] 20741 This P{EPgy2} insertion is largely uncharacterized but is oriented correctly to express RyR in the presence of GAL4.
RyR Mi{Trojan-GAL4.0}RyR[MI08146-TG4.0] 67480 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of RyR regulatory sequences.
RyR P{lacW}RyR[k04913] 10559 Hypomorphic mutation caused by insertion of P{lacW} upstream of the transcription start site or in the first intron (depending on the transcrip).
Scgdelta P{SUPor-P}Scgdelta[KG05430] 13543 This P{SUPor-P} insertion just upstream of the first exon causes heart defects.
Scgdelta P{TRiP.JF01984}attP2 25964 Expresses dsRNA for RNAi of Scgdelta (FBgn0025391) under UAS control
Scgdelta P{TRiP.HMC04012}attP40 55325 Expresses dsRNA for RNAi of Scgdelta (FBgn0025391) under UAS control.
Sdha SdhA[5] 1563 EMS-induced loss of function allele (amino acid change G533D)
Sdha SdhA[1110] 51659 SdhA loss of function allele caused by an E288K change.
Sdha P{EPg}SdhA[HP21216] 22087 This P{EPg} insertion in the first exon or intron (depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Sdha P{GSV1}SdhA[s-153.1] 43481 This P{GSV1} insertion just upstream of the transcription start could overexpress SdhA in the presence of GAL4.
SERCA SERCA[rev4] 58970 This allele carries the A617T change of the Ca-P60A[Unc-ts2] allele plus an unknown mutation causing loss of function (sequencing did not reveal a mutation in coding sequences so mutation likely falls in regulatory sequence).
SERCA SERCA[rev3] 58969 This allele carries the A617T change of the Ca-P60A[Unc-ts2] allele plus amino acid change Q55stop which causes loss of function.
SERCA SERCA[Kum295] 26707 EMS-induced mutation causes paralysis.
SERCA SERCA[Kum170] 26700 EMS-induced E442K change causes paralysis and heart defects.
SERCA P{TRiP.JF01948}attP2 25928 Expresses dsRNA for RNAi of Ca-P60A (FBgn0263006) under UAS control.
SERCA P{TRiP.HMS02878}attP2 44581 Expresses dsRNA for RNAi of Ca-P60A (FBgn0263006) under UAS control.
SERCA SERCA[11-2] 58977 This allele carries amino acid change M494L causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the M494L and M494I changes in human ATP2A2 associated with Darier Disease.
SERCA SERCA[10-34] 58976 This allele carries amino acid change R131H causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the R131Q and R131L changes in human ATP2A2 associated with Darier Disease.
SERCA SERCA[10-30] 58975 This allele carries amino acid change E412K causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the E412G change in human ATP2A2 associated with Darier Disease.
SERCA P{UAS-SERCA.tdTomato}56 59045 Expresses Tomato-tagged Ca-P60A under the control of UAS.
SERCA P{UAS-SERCA.F}8 63228 Expresses Ca-P60A (SERCA) under the control of UAS.
SERCA SERCA[Unc-ts2] 58968 Carries change A617T which causes a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{UAS-SERCA.S495P.tdTomato}47 58973 Expresses Tomato-tagged Ca-P60A carrying the amino acid change S495P under the control of UAS. S495P is analogous to a change in human ATP2A2 associated with Darier Disease.
SERCA P{UAS-SERCA.R751Q.tdTomato}18 58972 Expresses Tomato-tagged Ca-P60A carrying the amino acid change R751Q under the control of UAS. R751Q is analogous to the R750Q change in human ATP2A2 associated with Darier Disease.
SERCA P{UAS-SERCA.A617T.tdTomato}4 58971 Expresses Tomato-tagged Ca-P60A carrying the amino acid change A617T under the control of UAS. A617T is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{SERCA.A617T}51 58974 Expresses Tomato-tagged Ca-P60A carrying the amino acid change A617T under the control of Ca-P60A. A617T is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{lacW}SERCA[k08308ab] 12389 P{lacW} insertion in an intron of Ca-P60A fails to complement other Ca-P60A alleles
sesB sesB[9Ed-4] 8863 Hypomorphic allele.
sesB sesB[G0126] 11830 This {lacW} insertion is uncharacterized but an unverified lethal (suggesting it may disrupt function). It could affect sesB or Ant2.
sesB sesB[org] 27590 sesB mutant (amino acid change E266K)
sesB sesB[9Ed-1] 4687 sesB mutant (amino acid change A144T)
sesB P{TRiP.JF01810}attP2 31230 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.JF01528}attP2 31077 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.HMS01549}attP2 36661 Expresses dsRNA for RNAi of sesB (FBgn0003360) under the control of UAS.
sesB P{EP}sesB[EP319] 10108 This P{EP} insertion just upstream of the transcription start is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1577] 11287 This P{EP} insertion just upstream of the transcription start or in the first intron (depending on the transcript) is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1393] 11286 This P{EP} insertion in the first intron is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sls sls[1] 5048 sls mutation
sls Mi{MIC}sls[MI14515] 59633 This Mi{MIC} is inserted in sls coding sequence. It is uncharacterized but is an unverified lethal suggesting it may disrupt function.
sls Mi{MIC}sls[MI11177] 55582 This Mi{MIC} insertion in an intronic or a 3' non-coding exon (depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
sls P{TRiP.JF01099}attP2 31539 Expresses dsRNA for RNAi of sls (FBgn0086906) under UAS control
sls P{TRiP.JF01098}attP2 31538 Expresses dsRNA for RNAi of sls (FBgn0086906) under UAS control
sls Mi{Trojan-GAL4.1}sls[MI10783-TG4.1] 67495 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of sls regulatory sequences.
sls P{lacW}sls[j1D7] 10017 P{lacW} insertion into coding sequence, causing disruptions at amino acid 471.
SNF4Agamma SNF4Agamma[loe] 27905 This P{lacW} insertion in exon 7 causes loss of a SNF4Agamma isoform that is normally expressed strongly in the nervous system.
SNF4Agamma P{SUPor-P}SNF4Agamma[KG10152] 15233 This P{SUPor-P} insertion in intronic sequence is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
SNF4Agamma P{SUPor-P}SNF4Agamma[KG00325] 13088 This P{SUPor-P} insertion in intronic sequence may act as a loss of function allele.
SNF4Agamma P{TRiP.JF02060}attP2 26291 Expresses dsRNA for RNAi of SNF4Agamma (FBgn0264357) under UAS control.
SNF4Agamma P{TRiP.HMS01205}attP2 34726 Expresses dsRNA for RNAi of SNF4Agamma (FBgn0264357) under UAS control.
SNF4Agamma P{TRiP.GL00252}attP2 35341 Expresses dsRNA for RNAi of SNF4Agamma (FBgn0264357) under UAS control.
SNF4Agamma P{UAS-SNF4Agamma.GFP}3 59031 Expresses GFP-tagged SNF4Agamma protein under UAS control.
SNF4Agamma P{UAS-SNF4Agamma.GFP}2 59030 Expresses GFP-tagged SNF4Agamma protein under UAS control.
SNF4Agamma P{EPgy2}SNF4Agamma[EY07066] 16784 This P{EPgy2} insertion just upstream of the transcription start uncharacterized but is in the correct orientation to express SNF4Agamma in the presence of GAL4.
SNF4Agamma P{GMR33B06-GAL4}attP2 61642 Expresses GAL4 under the control of DNA sequences in or near SNF4Agamma.
SNF4Agamma PBac{IT.GAL4}SNF4Agamma[1398-G4] 65702 May express GAL4 in some or all of the pattern of the SNF4Agamma gene.
SNF4Agamma MI{Trojan-GAL4.1}SNF4Agamma[MI09417-TG4.1] 76202 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of SNF4Agamma regulatory sequences.
sqa Mi{MIC}sqa[MI09450] 53393 This Mi{MIC} insertion in intronic sequence is uncharacterized but is an unverified semi-lethal (suggesting it may disrupt function).
sqa P{TRiP.JF02277}attP2 26735 Expresses dsRNA for RNAi of CG42347 (FBgn0259678) under UAS control.
sqa P{TRiP.HMJ30185}attP40 63618 Expresses dsRNA for RNAi of sqa (FBgn0259678) under UAS control.
sqa P{TRiP.HMC06304}attP2 67752 Expresses dsRNA for RNAi of sqa (FBgn0259678) under UAS control.
sqa PBac{WH}sqa[f01512] 18446 This PBac{WH} insertion in sqa is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Taz P{TRiP.JF01748}attP2 31694 Expresses dsRNA for RNAi of Tafazzin (FBgn0026619) under UAS control.
Taz P{TRiP.JF01564}attP2 31099 Expresses dsRNA for RNAi of Tafazzin (FBgn0026619) under UAS control.
Taz P{TRiP.HMC03231}attP40 51484 Expresses dsRNA for RNAi of Tafazzin (FBgn0026619) under UAS control.
tin P{TRiP.HMC03064}attP2 50663 Expresses dsRNA for RNAi of tin (FBgn0004110) under UAS control.
tin P{TRiP.HM05025}attP2 28539 Expresses dsRNA for RNAi of tin (FBgn0004110) under UAS control.
tin PBac{tin-GFP.FPTB}VK00037 66397 Expresses GFP-, FLAG-, PreScission-, TEV- and BLRP-tagged tin protein.
Tm1 Tm1[Su(flw)4] 23708 Mutation in Tm1
Tm1 P{TRiP.HMS03526}attP40 56869 Expresses dsRNA for RNAi of Tm1 (FBgn0003721) under UAS control.
Tm1 P{TRiP.HMS01676}attP40 38232 Expresses dsRNA for RNAi of Tm1 (FBgn0003721) under UAS control.
Tm1 P{TRiP.GL01518}attP2 43542 Expresses dsRNA for RNAi of Tm1 (FBgn0003721) under UAS control.
Tm1 TI{TI}Tm1[KI.mCherry] 67408 A mCherry cassette was knocked into the Tm1 I-isoform locus to tag the endogenous protein at the N-terminus.
Tm1 P{PTT-GC}Tm1[CC00578] 51537 A P{PTT-GC} GFP protein trap in Tm1 (GFP is spliced into the Tm1 protein).
Tm1 P{EPgy2}Tm1[EY12089] 20344 This P{EPgy2} insertion is in an intron (or in 5' UTR depending on the transcript) but is an unverified lethal suggesting it may disrupt function.
Tm1 P{UASp-mKate2-Tm1.I}2 67405 Expresses the I-isoform of Tm1 with a N-terminal mKate2 fusion under UAS control. Rescues Tm1[eg1] amd Tm1[eg9] mutations.
Tm1 P{UASp-EmGFP-Tm1.I}2 67404 Expresses the I-isoform of Tm1 with a N-terminal EmGFP fusion under UAS control.
Tm1 PBac{IT.GAL4}Tm1[0561-G4] 63408 May express GAL4 in some or all of the pattern of the Tm1 gene.
Tm1 P{PZ}Tm1[02299] 11564 P{PZ} insertion at amino acid 20 causes loss of function
Tm2 Tm2[3] 4053 A copia-like insertion into the transcribed region results in loss of the muscle-specific tropomyosin isoform
Tm2 P{TRiP.JF01095}attP2 31535 Expresses dsRNA for RNAi of Tm2 (FBgn0004117) under UAS control.
Tm2 P{TRiP.HMS02260}attP2 41695 Expresses dsRNA for RNAi of Tm2 (FBgn0004117) under UAS control.
Tm2 P{PTT-GC}Tm2[ZCL2456] 6829 This P{PTT-GC} insertion into Tm2 is largely uncharacterized but is an unverified lethal suggesting it may disrupt function. This is a GFP 'trap' and it minimally expresses GFP in the ovaries and in indirect flight muscle.
TpnC41C P{TRiP.JF02379}attP2 27053 Expresses dsRNA for RNAi of TpnC41C (FBgn0013348) under UAS control.
TpnC47D P{TRiP.JF02067}attP2 26172 Expresses dsRNA for RNAi of TpnC47D (FBgn0010423) under UAS control.
TpnC47D P{TRiP.HMJ30316}attP40 64003 Expresses dsRNA for RNAi of TpnC47D (FBgn0010423) under UAS control.
TpnC73F Mi{ET1}TpnC73F[MB03946] 24549 This Mi{ET1} insertion in the fourth intron of TpnC73F is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
up up[1] 25402 An A->T mutation at the 3' end of the intron preceding exon 10a results in mis-splicing.
up up[101] 25403 Amino acid change E88K
up P{TRiP.JF01102}attP2 31541 Expresses dsRNA for RNAi of up (FBgn0004169) under UAS control.
up P{TRiP.HMS00743}attP2 32949 Expresses dsRNA for RNAi of up (FBgn0004169) under UAS control.
Vinc Vinc[1] 6030 Amorphic allele caused by the insertion of satellite DNA.
Vinc P{TRiP.JF01985}attP2 25965 Expresses dsRNA for RNAi of Vinc (FBgn0004397) under UAS control.
Vinc P{TRiP.HMS02356}attP2 41959 Expresses dsRNA for RNAi of Vinc (FBgn0004397) under UAS control.
Vinc P{UASp-alpha-Cat.DeltaVH3::VincVH3}attP2 67750 Expresses alpha-Cat under the control of UAS with the VH3 domain replaced by the VH3 domain from Vinculin.
wupA P{TRiP.JF02172}attP2 31893 Expresses dsRNA for RNAi of wupA (FBgn0004028) under UAS control.
Zasp52 PBac{WHr}Zasp52[Delta] 59018 FRT-based recombination between PBac{WH}Zasp52[f04847] and PBac{WH}Zasp52[f04784] results in a deletion removing Zasp52 exons 5-9 and a frameshift.
Zasp52 Mi{MIC}Zasp52[MI07547] 43724 This Mi{MIC} insertion in intronic sequence is uncharacterized but is an unverified lethal (suggesting it may disrupt function).
Zasp52 P{TRiP.JF01133}attP2 31561 Expresses dsRNA for RNAi of Zasp52 (FBgn0083919) under UAS control.
Zasp52 P{TRiP.HMJ22168}attP40 58198 Expresses dsRNA for RNAi of Zasp52 (FBgn0083919) under UAS control.
Zasp52 P{PTT-GB}Zasp52[G00189] 6838 This P{PTT-GB} insertion in the second intron acts as a protein trap.
Zasp52 MI{Trojan-GAL4.0}Zasp52[MI02988-TG4.0] 76159 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of Zasp52 regulatory sequences.
zip zip[IIX62] 2528 Loss of function allele caused by a deficiency with a breakpt in zip
zip zip[2] 8739 Loss of function allele caused by aa change Q751@
zip zip[1] 4199 Loss of function allele
zip P{TRiP.HMS01703}attP40 38259 Expresses dsRNA for RNAi of zip (FBgn0005634) under UAS control.
zip P{TRiP.HMS01618}attP2 36727 Expresses dsRNA for RNAi of zip (FBgn0005634) under UAS control.
zip P{TRiP.HMC06222}attP2 65947 Expresses dsRNA for RNAi of zip (FBgn0265434) under UAS control.
zip P{TRiP.GL00623}attP40 37480 Expresses dsRNA for RNAi of zip (FBgn0005634) under UAS control.
zip P{PTT-GC}zip[CC01626] 51564 This P{PTT-GC} insertion in the second intron acts as a protein trap.
zip Mi{PT-GFSTF.0}zip[MI03943-GFSTF.0] 63172 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of zip tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
zip Mi{PT-GFSTF.0}zip[MI02518-GFSTF.0] 66894 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of zip tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
zip Mi{Trojan-GAL4.0}zip[MI03943-TG4.0] 66793 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of zip regulatory sequences.
zip Mi{Trojan-GAL4.0}zip[MI02518-TG4.0] 67443 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of zip regulatory sequences.
zip P{PZ}zip[02957] 11215 This P{PZ} insertion in the first intron results in zip defects.