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Frontotemporal dementia and/or Amyotrophic lateral sclerosis (FTDALS1)
Frontotemporal dementia (FTD) and/or amyotrophic lateral sclerosis (ALS) is an autosomal dominant neurodegenerative disorder caused by expansion of a hexnucleotide repeat (GGGCC) in the C9orf72 gene. FTDALS1 is form of ALS accompanied by progressive dementia affecting personality, behavior and language. Not all ALS patients with expanded repeats develop FTD.

Go to the Amyotrophic lateral sclerosis page.

General information links for FTPALS1:
OMIM
NIH's Genetics Home Reference
Weizmann Institute of Science's MalaCards
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
      Stocks for studying expanded GGGCC repeats
GGGGCC repeats P{UAS-GGGGCC.108-RO}attP40 58690 Expresses 'RNA only' from 108 RNA repeats of 'GGGGCC' (stop codons in all frames interrupt translation) under the control of UAS.
GGGGCC repeats P{UAS-GGGGCC.288-RO}attP40 58691 Expresses 'RNA only' from 288 RNA repeats of 'GGGGCC' (stop codons in all frames interrupt translation) under the control of UAS.
GGGGCC repeats P{UAS-GGGGCC.36-RO}attP40 58689 Expresses 'RNA only' from 36 RNA repeats of 'GGGGCC' (stop codons in all frames interrupt translation) under the control of UAS.
GGGGCC repeats P{UAS-GGGGCC.36}attP40 58688 Expresses RNA and protein from 36 'pure' repeats of 'GGGGCC' under the control of UAS.
GGGGCC repeats P{UAS-GGGGCC.3}attP40 58687 Expresses RNA and protein from 3 'pure' repeats of 'GGGGCC' under the control of UAS.
poly-GA P{UAS-poly-GR.PO-36}attP40 58692 Expresses 36 dipeptide repeats of glycine-arginine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-GA P{UAS-poly-GA.PO-36}attP40 58693 Expresses 36 dipeptide repeats of glycine-alanine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-GR P{UAS-poly-PA.PO-36}attP40 58695 Expresses 36 dipeptide repeats of proline-alanine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-GR P{UAS-poly-PR.PO-36}attP40 58694 Expresses 36 dipeptide repeats of proline-arginine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-PA P{UAS-poly-GR.PO-100}attP40 58696 Expresses 100 dipeptide repeats of glycine-arginine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-PA P{UAS-poly-GA.PO-100}attP40 58697 Expresses 100 dipeptide repeats of glycine-alanine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-PR P{UAS-poly-PA.PO-100}attP40 58699 Expresses 100 dipeptide repeats of proline-alanine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.
poly-PR P{UAS-poly-PR.PO-100}attP40 58698 Expresses 100 dipeptide repeats of proline-arginine utilizing alternative codons to those in the GGGGCC repeat found in stks 58687 to 58691. Expression is under the control of UAS.