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P-type ATPase-related disorders
P-type ATPases couple ATP hydrolysis with the transport of ions across membranes. Several autosomal dominant disorders are associated with mutations in P-type ATPases including Darier disease (a disorder characterized by hard yellow blemishes on the skin and mucous membranes), Familial hemipeglic migraine, and Rapid-onset dystonia parkinsonism.

General information links:
Darier disease
Familial hemiplegic migraine
Rapid-onset dystonia parkinsonism
Hailey-Hailey disease
Causative genes for P-type ATPase-related disorders
Disorder Human gene Human full name Fly gene
Migraine, familial hemiplegic ATP1A2 ATPase, Na+/K+ transporting, alpha-2 polypeptide Atpalpha
dystonia parkinsonism ATP1A3 ATPase, Na+/K+ transporting, alpha-3 polypeptide Atpalpha
Brody myopathy ATP2A1 ATPase, Ca(2+)-transporting, fast twitch Ca-P60A
Darier disease ATP2A2 ATPase, Ca(2+)-transporting, slow twitch Ca-P60A
Hailey-Hailey disease ATP2C1 ATPase, Ca(2+)-transporting, type 2C, member 1 SPoCk

Stocks for studying Zellweger spectrum disorders (in alphabetical order)
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
Atpalpha P{PZ}Atpalpha[01453a] 11533 This P{PZ} insertion acts as a Atpalpha mutation.
Atpalpha Mi{MIC}Atpalpha[MI05598] 40229 This Mi{MIC} insertion is uncharacertized but is an unverified lethal suggesting it may disrupt function.
Atpalpha P{EPgy2}Atpalpha[EY05545] 15451 This P{EPgy2} insertion is uncharacertized but is an unverified lethal suggesting it may disrupt function.
Atpalpha P{TRiP.GLC01778}attP40 51411 Expresses dsRNA for RNAi of Atpalpha (FBgn0002921) under UAS control.
Atpalpha P{TRiP.HMS00047}attP2 33646 Expresses dsRNA for RNAi of Atpalpha (FBgn0002921) under UAS control.
Atpalpha P{TRiP.HMS00703}attP2 32913 Expresses dsRNA for RNAi of Atpalpha (FBgn0002921) under UAS control.
Atpalpha P{TRiP.JF02910}attP2 28073 Expresses dsRNA for RNAi of Atpalpha (FBgn0002921) under UAS control.
Atpalpha P{PTT-GC}Atpalpha[G00109] 6834 This P{PTT-GC} insertion acts as a protein trap resulting in expression of a GFP-tagged Atpalpha.
Atpalpha P{EPgy2}Atpalpha[EY02875] 19992 This P{EPgy2} insertion is uncharacterized but is oriented such that it might overexpress Atpalpha in the presence of GAL4.
Atpalpha P{GMR66A12-GAL4}attP2 41296 Expresses GAL4 under the control of DNA sequences in or near Atpalpha (FBgn0002921). There are more GAL4 lines, see our GAL4 page - http://flystocks.bio.indiana.edu/Browse/gal4/gal4_main.htm.
Atpalpha P{GMR66A12-lexA}attP40 54180 Expresses lexA under the control of DNA sequences in or near Atpalpha.
SERCA SERCA[rev3] 58969 This allele carries the A617T change of the Ca-P60A[Unc-ts2] allele plus amino acid change Q55stop which causes loss of function.
SERCA SERCA[rev4] 58970 This allele carries the A617T change of the Ca-P60A[Unc-ts2] allele plus an unknown mutation causing loss of function (sequencing did not reveal a mutation in coding sequences so mutation likely falls in regulatory sequence).
SERCA P{TRiP.HMS02878}attP2 44581 Expresses dsRNA for RNAi of Ca-P60A (FBgn0263006) under UAS control.
SERCA P{TRiP.JF01948}attP2 25928 Expresses dsRNA for RNAi of Ca-P60A (FBgn0263006) under UAS control.
SERCA SERCA[10-30] 58975 This allele carries amino acid change E412K causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the E412G change in human ATP2A2 associated with Darier Disease.
SERCA SERCA[10-34] 58976 This allele carries amino acid change R131H causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the R131Q and R131L changes in human ATP2A2 associated with Darier Disease.
SERCA SERCA[11-2] 58977 This allele carries amino acid change M494L causing a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the M494L and M494I changes in human ATP2A2 associated with Darier Disease.
SERCA SERCA[Kum170] 26700 Carries change E422K which causes a dominant temperature-sensitive paralysis.
SERCA SERCA[Kum295] 26707 Carries change C318S which causes a dominant temperature-sensitive paralysis. C318 is analogous to the C318F and C318R changes in human ATP2A2 associated w/ Darier's and the C333F change in ATP1A3 associated w/ alternating childhood hemiplegia (AHC2).
SERCA P{UAS-SERCA.tdTomato}56 59045 Expresses Tomato-tagged Ca-P60A under the control of UAS.
SERCA P{SERCA.A617T}51 58974 Expresses Tomato-tagged Ca-P60A carrying the amino acid change A617T under the control of Ca-P60A. A617T is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{UAS-SERCA.A617T.tdTomato}4 58971 Expresses Tomato-tagged Ca-P60A carrying the amino acid change A617T under the control of UAS. A617T is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{UAS-SERCA.R751Q.tdTomato}18 58972 Expresses Tomato-tagged Ca-P60A carrying the amino acid change R751Q under the control of UAS. R751Q is analogous to the R750Q change in human ATP2A2 associated with Darier Disease.
SERCA P{UAS-SERCA.S495P.tdTomato}47 58973 Expresses Tomato-tagged Ca-P60A carrying the amino acid change S495P under the control of UAS. S495P is analogous to a change in human ATP2A2 associated with Darier Disease.
SERCA SERCA[Unc-ts2] 58968 Carries change A617T which causes a dominant temperature-sensitive uncoordinated phenotype. This mutation is analogous to the A606T change in human ATP1A2 associated with Familial Hemiplegic Migraine.
SERCA P{lacW}SERCA[k08308ab] 12389 P{lacW} insertion in an intron of Ca-P60A fails to complement other Ca-P60A alleles
SPoCk Mi{MIC}SPoCk[MI05781] 43024 This Mi{MIC} insertion is uncharacertized but is an unverified lethal suggesting it may disrupt function.
SPoCk P{TRiP.HMS02756}attP40 44040 Expresses dsRNA for RNAi of SPoCk (FBgn0052451) under UAS control.
SPoCk P{TRiP.JF02988}attP2 28352 Expresses dsRNA for RNAi of SPoCk (FBgn0052451) under UAS control.