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Peroxisome disorders (non-Zellweger spectrum)
Disorders caused by defects in peroxisome biogenesis or function can be severe and wide-ranging in their effects. Many peroxisome disorders fall under the heading of Zellweger spectrum disorders - please see our Zellweger spectrum page for stocks related to these disorders. Non-Zellweger spectrum disorders can be found here. Please see links below and in the table for the unique characteristics associated with each disease.

General information links for Peroxisome disorders:
Browse for individual diseases at NLM/NIH's Genetic and Rare Disease Information Center
Browse for individual diseases at the Genetics Home Reference
Causative genes for Peroxisome disorders
Disorder Human gene Human full name Fly gene
Peroxisomal acyl-CoA oxidase deficiency ACOX1 Acyl-CoA oxidase 1, palmitoyl CG5009
Rhizomelic chondrodysplasia punctata, type 1 PEX7 Peroxisome biogenesis factor 7 Pex7
Rhizomelic chondrodysplasia punctata, type 3 AGPS Alkylglycerone-phosphate synthase CG10253
Refsum disease PHYH Phytanoyl-CoA hydrolase CG14688
Adrenoleukodystrophy ABCD1 ATP-binding cassete, subfamily D, member 1 CG2316

Stocks for studying Peroxisome disorders
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
ADPS PBac{WH}ADPS[f02060] 18510 This PB{WH} insertion in coding sequence (in the 3rd or 4th exon depending on the transcript) is uncharacterized but is an unverified lethal suggesting it may disrupt function.
ADPS P{TRiP.HMS01339}attP2 34350 Expresses dsRNA for RNAi of CG10253 (FBgn0033983) under UAS control.
CG2316 P{TRiP.HMS02382}attP2 41984 Expresses dsRNA for RNAi of CG2316 (FBgn0039890) under UAS control.
CG5009 P{EPgy2}CG5009[EY06760] 16755 This P{EPgy2} insertion in 5' noncoding is uncharacterized but is an unverified lethal suggesting it may disrupt function.
CG5009 P{TRiP.HMC03620}attP40 52882 Expresses dsRNA for RNAi of CG5009 (FBgn0027572) under UAS control.
CG5009 P{EPgy2}CG5009[EY10858] 20226 This P{EPgy2} insertion just 5' of CG5009 is largely uncharacterized but is oriented correctly to express CG5009 in the presence of GAL4.
CG14688 Mi{MIC}CG14688[MI09246] 51268 This Mi{MIC}} insertion in the first intron transcript is uncharacterized but is an unverified lethal suggesting it may disrupt function.