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Seizure disorders/epilepsy
Several types of fly mutants with epileptic phenotypes are currently used in modeling seizures. The so-called "bang-sensitive" mutants exhibit seizures and paralysis upon mechanical stimuli; seizures can be suppressed by the administration of anticonvulsant drugs. Seizure-suppressor mutants include Sh, shakB and para. Fly stocks in the Bloomington collection that can be used to study seizure disorders and epilepsy are listed here.

fly gene human gene or gene type mutant phenotype in flies
couch potato (cpo) RNA binding protein with multiple splicing 2 (RBPMS2) bang-sensitive
easily shocked (eas) ethanolamine kinase (ETNK1) bang-sensitive
ether a go-go (eag) voltage-gated potassium channels, subfamily H (e.g. KCNH5) bang-sensitive
jitterbug (jbug) filamins bang-sensitive
kazachoc (kcc) potassium/chloride transporters - solute carrier family 12 (e.g. SLC12A4) bang-sensitive
knockdown (kdn) citrate synthase (CS) bang-sensitive
Letm1 LETM1  
paralytic (para) voltage-gated sodium channel, type III (SCN3A) temperature-sensitive paralytic
seizure (sei) voltage-gated potassium channel, subfamily H (e.g. KCNH2) temperature-sensitive paralytic
Shaker (Sh) voltage-gated potassium channels, shaker-related (e.g. KCNA3) uncoordinated/behaviour defective
shaking B (shakB) gap junction proteins uncoordinated/behaviour defective
slamdance (sda) alanyl (membrane) aminopeptidase (ANPEP) bang-sensitive
slowpoke (slo) large conductance calcium-activated potassium channels (e.g. KCNMA1) temperature-sensitive paralytic
stress-sensitive B (sesB) adenine nucleotide translocator, solute carrier family 25 (e.g. SLC25A4) bang-sensitive
technical knockout (tko) mitochondrial ribosomal protein S12 (MRPS12) bang-sensitive
Relevant gene in stock Fly disease model or related mutation or transgene Stk # Comments
couch potato (cpo)
cpo P{lArB}cpo[2] 39666 P{lArB} insertion in cpo intron upstream of transcription results in a hypomorphic allele
cpo P{lArB}cpo[1] 39665 P{lArB} insertion in cpo intron upstream of transcription results in a hypomorphic allele. Expresses lacZ in sensory organ mother cells and oocyte-associated follicle cells.
cpo P{TRiP.JF02996}attP2 28360 Expresses dsRNA for RNAi of cpo under UAS control.
cpo P{TRiP.HMJ22606}attP40 60388 Expresses dsRNA for RNAi of cpo (FBgn0263995) under UAS control.
cpo P{ST.lexA::HG}cpo[JHW-2] 66641 Expresses lexA in the eye disc, CNS, VNC, PNS, comet cells (gut), midgut, garland nephrocytes, lymph gland, and salivary gland under the control of cpo.
cpo P{PZ}cpo[01432] 11531 Insertion of lacZ-containing P{PZ} element, lacZ expression is seen in adult.
easily shocked (eas)
eas eas[alaE13] 9463 eas strong hypomorph (excision of a P{GawB} insertion)
eas P{SUPor-P}eas[KG01772] 14246 This P{SUPorP} insertion in noncoding exon 1 results in a hypomorphic allele.
eas P{GawB}eas[alaP] 9462 eas hypomorph (P{GawB} insertion at nucleotide 38); expresses GAL4 in the mushroom body of the adult brain.
eas P{TRiP.HMS01734}attP2 38528 Expresses dsRNA for RNAi of eas (FBgn0000536) under UAS control.
eas P{EP}eas[EP770] 10135 P{EP} insertion ~2.5 kb upstream of eas translation start. May overexpress eas in presence of GAL4 driver.
ether a go-go (eag)
eag eag[sc29] 1442 eag mutant (inversion with one breakpoint in eag)
eag eag[1] 3561 eag hypomorphic mutant with C-terminus truncated
eag P{TRiP.JF01472}attP2 31679 Expresses dsRNA for RNAi of eag under UAS control.
eag P{TRiP.JF01471}attP2 31678 Expresses dsRNA for RNAi of eag under UAS control.
eag P{UAS-eag.DN.EKI}2 8187 First 195 amino acids of eag followed by 14 novel amino acids under the control of UAS.
jitterbug (jbug)
jbug P{SUPor-P}jbug[KG00131] 13045 This P{SUPor-P} insertion is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/17/2010.
jbug P{GT1}jbug[BG00406] 12485 This P{GT1} insertion is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/17/2010.
jbug Mi{MIC}jbug[MI00056] 30605 This Mi{MIC} insertion is uncharacterized but contains an attP-based swappable cassette for phiC31 integrase-mediated insertion of your construct of choice. 8/13/2010
jbug P{TRiP.JF01166}attP2 31590 Expresses dsRNA for RNAi of jbug under UAS control.
jbug P{TRiP.HMS01990}attP2 39070 Expresses dsRNA for RNAi of jbug (FBgn0028371) under UAS control.
kazachoc (kcc)
kcc P{EPgy2}kcc[EY08304] 16887 kcc mutant (P{EPgy2} insertion in last exon of kcc)
kcc kcc[P20-180] 5206 kcc mutant
kcc kcc[Ad-4] 5207 kcc mutant
kcc P{TRiP.HMS01058}attP2 34584 Expresses dsRNA for RNAi of kcc (FBgn0025698) under the control of UAS.
kcc Mi{PT-GFSTF.2}kcc[MI04746-GFSTF.2] 65328 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of kcc tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
kcc Mi{Trojan-GAL4.2}kcc[MI04746-TG4.2] 66858 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of kcc regulatory sequences.
knockdown (kdn)
kdn P{lacW}kdn[G0140a] 11936 This P{lacW} in the first or second intron (depending on the transcript) results in a 30% decrease in citrate synthase activity when heterozygous.
kdn P{SUPor-P}kdn[KG04873] 14436 kdn mutant (P{SUPorP} insertion into the first or second intron (depending on the transcript).
kdn P{lacW}kdn[G0159] 11943 This insertion of a P{lacW} element (in the first or second intron depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/16/2010.
kdn P{lacW}kdn[G0033] 10071 This insertion of a P{lacW} element (in the first or second intron depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/16/2010.
kdn P{lacW}kdn[G0030] 11516 This insertion of a P{lacW} element (in the first or second intron depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/16/2010.
kdn kdn[B] 52365 A lethal allele caused by aa change K393stop (PB isoform). Some or all homozygotes die as first instar larvae.
kdn kdn[A] 52364 A lethal allele caused by aa change W370stop (PB isoform). Some or all homozygotes die as first instar larvae.
kdn P{TRiP.HMS01631}attP40 36740 Expresses dsRNA for RNAi of kdn (FBgn0261955) under the control of UAS.
Letm1
Letm1 Mi{ET1}Letm1[MB02246] 23794 This insertion of an Mi{ET1} element (in the third exon) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/17/2010.
Letm1 P{TRiP.HMS01644}attP40 37502 Expresses dsRNA for RNAi of Letm1 (FBgn0019886) under the control of UAS.
Letm1 PBac{IT.GAL4}Letm1[0184-G4] 64696 May express GAL4 in some or all of the pattern of the etm1 gene.
paralytic (para)
para para[sbl-2] 62099 temperature-sensitive behavioral mutant
para para[sbl-1] 60687 temperature-sensitive behavioral mutant
para para[ST76] 26701 para mutant
para para[B] 57109 An allele of para (aa change V1424E)
para para[A] 57108 An allele of para (aa change N343I)
para P{TRiP.JF01469}attP2 31676 Expresses dsRNA for RNAi of para under UAS control.
para P{TRiP.JF01245}attP2 31471 Expresses dsRNA for RNAi of para under UAS control.
para P{TRiP.HMS00868}attP2 33923 Expresses dsRNA for RNAi of para (FBgn0260993) under the control of UAS.
para P{EPgy2}para[EY08038] 17420 This UAS-bearing P{EPgy2} insertion 5prime of para can overexpress para in the presence of GAL4.
para P{GMR16G04-lexA}attP40 61514 Expresses lexA under the control of DNA sequences in or near para.
para P{GMR16D10-lexA}attP40 61512 Expresses lexA under the control of DNA sequences in or near para.
seizure (sei)
sei P{EPg}sei[HP21840] 21935 This P{EPg} insertion in the 9th exon (a coding exon) disrupts sei function.
sei Mi{MIC}sei[MI15686] 61130 This Mi{MIC} insertion in sei coding sequence is uncharacterized.
sei P{TRiP.JF01475}attP2 31682 Expresses dsRNA for RNAi of sei under UAS control.
sei P{TRiP.JF01474}attP2 31681 Expresses dsRNA for RNAi of sei under UAS control.
Shaker (Sh)
Sh Sh[14] 4752 aka Sh[KS133]; V413N mutation causes loss of function
Sh Sh[14] 3563 aka Sh[KS133]; V413N mutation causes loss of function
Sh Sh[mns] 24149 T203I mutation causes behavioral and longevity defects
Sh Sh[5] 111 F401I mutation changes channel kinetics
Sh Mi{ET1}Sh[MB00560] 22837 This Mi{ET1} insertion in a Sh intron results in disruption of Sh.
Sh P{TRiP.JF01473}attP2 31680 Expresses dsRNA for RNAi of Sh under UAS control.
Sh P{TRiP.HMC03576}attP40 53347 Expresses dsRNA for RNAi of Sh (FBgn0003380) under UAS control.
Sh Mi{PT-GFSTF.2}Sh[MI10885-GFSTF.2] 59423 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Sh tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Sh Mi{PT-GFSTF.2}Sh[MI07022-GFSTF.2] 60553 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Sh tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
Sh P{UAS-EKO[+]}323 40973 Expresses a mutated Shaker potassium channel to attenuate membrane excitability.
Sh P{UAS-EKO[+]} (3 copies) 40975 Expresses a mutated Shaker potassium channel to attenuate membrane excitability.
Sh P{UAS-EKO[+]} (2 copies) 40974 Expresses a mutated Shaker potassium channel to attenuate membrane excitability.
shaking B (shakB)
shakB shakB[25] 4769 shakB mutant (amino acid change L299stop)
shakB shakB[20] 7478 shakB mutant
shakB shakB[15] 8132 shakB mutant
shakB P{TRiP.JF02604}attP2 27292 Expresses dsRNA for RNAi of shakB under UAS control.
shakB P{TRiP.JF02603}attP2 27291 Expresses dsRNA for RNAi of shakB under UAS control.
shakB P{TRiP.HMC04895}attP2 57706 Expresses dsRNA for RNAi of shakB under UAS control.
shakB Mi{PT-GFSTF.2}shakB[MI02168-GFSTF.2] 60524 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of shakB tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
shakB P{shakB(lethal)-GAL4.4.1}2GL152 51633 Expresses GAL4 in the tergotrochanteral (jump) muscle motoneuron and other neurons.
slamdance (sda)
sda P{TRiP.HMS01636}attP2 37494 Expresses dsRNA for RNAi of sda (FBgn0015541) under the control of UAS.
slowpoke (slo)
slo slo[1] 4587 slo mutant
slo Mi{MIC}slo[MI13492] 59344 This Mi{MIC} insertion is in a slo intron and is uncharacterized but is an unverified lethal suggesting it may disrupt function.
slo P{TRiP.JF02146}attP2 26247 Expresses dsRNA for RNAi of slo under UAS control.
slo P{TRiP.JF01470}attP2 31677 Expresses dsRNA for RNAi of slo under UAS control.
slo P{TRiP.JF01246}attP2 31300 Expresses dsRNA for RNAi of slo under UAS control.
slo P{TRiP.HMC04093}attP40 55405 Expresses dsRNA for RNAi of slo (FBgn0003429) under UAS control.
slo Mi{PT-GFSTF.2}slo[MI04413-GFSTF.2] 60542 Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of slo tagged with EGFP-FlAsH-StrepII-TEV-3xFlag.
stress-sensitive B (sesB)
sesB sesB[9Ed-4] 8863 Hypomorphic allele.
sesB sesB[org] 27590 sesB mutant (amino acid change E266K)
sesB sesB[G0386] 12251 This P{lacW} inserted into the 1st intron likely disrupts sesB. Chromosome may carry an extraneous lethal.
sesB sesB[9Ed-1] 4687 sesB mutant (amino acid change A144T)
sesB sesB[G0247] 11959 This {lacW} insertion is uncharacterized but an unverified lethal (suggesting it may disrupt function). It could affect sesB or Ant2.
sesB sesB[G0126] 11830 This {lacW} insertion is uncharacterized but an unverified lethal (suggesting it may disrupt function). It could affect sesB or Ant2.
sesB P{TRiP.JF01810}attP2 31230 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.JF01528}attP2 31077 Expresses dsRNA for RNAi of sesB under UAS control.
sesB P{TRiP.HMS01549}attP2 36661 Expresses dsRNA for RNAi of sesB (FBgn0003360) under the control of UAS.
sesB sesB[EY08924] 19943 This P{EP} insertion in the first intron is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP319] 10108 This P{EP} insertion just upstream of the transcription start is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1577] 11287 This P{EP} insertion just upstream of the transcription start or in the first intron (depending on the transcript) is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
sesB P{EP}sesB[EP1393] 11286 This P{EP} insertion in the first intron is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
technical knockout (tko)
tko tko[B] 52401 A lethal allele caused by aa change Q6@. Some or all homozygotes die as second instar larvae.
tko tko[A] 52400 A lethal allele caused by aa change L85H. Some or all homozygotes die as third instar larvae.
tko tko[3] 4283 insertion/deletion at amino acid 108-109 resulting in a frameshift and premature stop codon
tko Mi{MIC}tko[MI15120] 59642 This Mi{MIC} is inserted tko noncoding sequence. It is uncharacterized but is an unverified lethal suggesting it may disrupt function.
tko P{TRiP.HMS01695}attP40 38251 Expresses dsRNA for RNAi of tko (FBgn0003714) under the control of UAS.