Alzheimer disease is the most common cause of degenerative dementia in the elderly. The causes of late-onset Alzheimer disease are unclear; risk factors such as mutations in the APOE gene may be involved. Mutations in three genes have been associated with early-onset Alzheimer disease - APP, PSEN1, and PSEN2. Fly stocks in the Bloomington collection that can be used to study Alzheimer Disease are listed here.
General Information links for Alzheimer disease:
OMIM (see also links in table below)
| Genes for studying Alzheimer disease | |||
|---|---|---|---|
| Human gene(s) | Human full name | Fly gene | OMIM link and/or comments |
| APH1A and APH1B | Anterior pharynx defective 1A and 1B | anterior pharynx defective 1 (aph-1) | gamma-secretase complex member |
| APP | Amyloid beta A4 Precursor Protein | beta amyloid protein precursor-like (Appl) | Alzheimer disease 1/precursor of peptide found in senile plaques |
| APLP1 and APLP2 | Amyloid beta A4 Precursor-like Protein 1 and 2 | ||
| BACE1 | beta-site Amyloid beta A4 Precursor Protein-cleaving enzyme 1 | beta-secretase | |
| Fe65/APBB1 | Amyloid beta A4 Precursor Protein-binding, family B, member 1 | APP-binding protein | |
| HSD17B10/ERAB | hydroxysteroid (17-beta) dehydrogenase 10 | scully (scu) | multifunctional mitochondrial enzyme |
| MARK3, MARK1, MARK2, MARK4 | Microtubule affinity-regulating kinase | par-1 | tau kinase |
| NCSTN | Nicastrin | Nicastrin (Nct) | gamma-secretase complex member |
| PSEN1 and PSEN2 | Presenilin-1 and Presenilin-2 | Presenilin (Psn) | Alzheimer disease 3 and 4/gamma-secretase complex member |
| PEN2/PSENEN | Presenilin enhancer 2 | presenilin enhancer (pen-2) | gamma-secretase complex member |
| Tau (MAPT) | Microtubule-associated protein tau | tau | neurofibrillary tangle component |
