Metabolism/Diabetes/Obesity

Metabolic dysfunction is associated with a wide variety of human disorders and health-related issues, including cardiovascular disease, diabetes, and obesity. Many of the genes and tissues involved in energy homeostasis, carbohydrate and lipid metabolism, nutrient uptake and storage, and other basic metabolic functions are conserved in flies. Fly stocks in the Bloomington collection that can be used to study human metabolism and related diseases and conditions such as diabetes and obesity are listed here. Other metabolic diseases for which we currently have pages include Niemann-Pick disease and Neuronal ceroid lipofuscinosis.

Jason Tennessen has generated a downloadable Excel spreadsheet of Drosophila genes predicted or known to function in metabolic pathways. Get the list here.

Protein typeHuman gene(s) full nameHuman gene(s) symbolFly gene(s)
acyl-CoA dehydrogenases  Enigma (Egm)
acyl-CoA synthetasesacyl-CoA synthetase bubblegum family member 2ACSBG2bubblegum (bgm)
long chain acyl-CoA synthasesAcyl-CoA synthetase long chain family member 3 and 4ACSL3 and ACSL4Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3)
AKT (Protein kinase B/PKB) kinasesAKT3 (PKB-gamma)AKT2Akt1
diacylglycerol O-acyltransferasesdiacylglycerol O-acyltransferase 1DGAT1midway (mdy)
4E-BPsEukaryotic translation initiation factor 4E-binding proteins 1, 2, & 3EIF4EBP1, EIF4EBP2, and EIF4EBP3Thor (most similar to EIF4EBP2)
FGGY carbohydrate kinase domain-containing proteinFGGYCG11594
 forkhead box protein O1AFOXO1forkhead box, sub-group O (foxo)
FERM domain containing proteinsFERM domain containing 6FRMD6expanded (ex)
 glucagonGCGAdipokinetic hormone (Akh) (functional homolog)
 Hepatocyte nuclear factor 4-alphaHNF4AHepatocyte nuclear factor 4 (Hnf4)
 InsulinINSInsulin-like peptides: Ilp1, Ilp2, Ilp3, Ilp4, Ilp5, Ilp6, and Ilp7
Insulin and IGF receptorsInsulin receptor and insulin-like growth factor 1 receptorINSR and IGF1R (respectively)Insulin receptor (InR)
Insulin receptor substratesInsulin receptor substrate 1IRS1chico
lipase  mag
 malate dehydrogenase, mitochondrialMDH2Mdh2
 Mediator complex subunit 24MED24MED24
   mir-14
 MAP kinase interacting serine/threonine kinase 1Mnk/MKNK1Lk6
 mammalian Target of RapamycinmTOR/FRAP1Tor
 nuclear receptor subfamily 1 group I member 2NR1I2Hr96
 nuclear receptor subfamily 4, group A, member 2NR4A2Hr38
 nuclear receptor subfamily 5, group A, members 1 & 2NR5A1 and NR5A2ftz-f1
Pi3 kinasesPhosphatidylinositol 3-Kinase, Class 2, AlphaPIK3C2APhosphatidylinositol 3 kinase 68D (Pi3K68D)
Pi3 kinasesPhosphatidylinositol 3-Kinase, catalytic, betaPIK3CBPi3K92E
 Perilipin 1PLIN1Lipid storage droplet-2 (Lsd-2)
 patatin-like phospholipase domain containing 2PNPLA2/ATGLbrummer (bmm)
 patatin-like phospholipase domain containing 6PNPLA6/NTEswiss cheese (sws)
 Phosphatase and tensin homologPTENPten
 SREBP cleavage-activating proteinSCAPSCAP
stearyl-CoA desaturasesstearyl-CoA desaturase 1SCDDesat1
 succinate dehydrogenase complex assembly factor 3SDHAF3Sdhaf3
 succinate dehydrogenase complex assembly factor 4SDHAF4Sirup
 Sphingosine-1-phosphate lyaseSGPL1sphingosine-1-phosphate lyase (Sply)
mitochondrial solute carrierssolute carrier family 25 (mitochondrial carrier; citrate transporter), member 1SLC25A1/CTPscheggia (sea)
mitochondrial solute carrierssolute carrier family 25 (mitochondrial carrier; adenine transporter), member 4, 5 and 6SLC25A4, SLC25A5, and SLC25A6stress-sensitive B (sesB), and Adenine nucleotide translocase 2 (Ant2)
mitochondrial solute carrierssolute carrier family 25 (an uncoupling protein or UCP), member 14 and 30SLC25A14 and SLC25A30Bmcp
nucleoside solute carrierssolute carrier family 29 (nucleoside transporters), member 3SLC29A3Equilibrative nucleoside transporter 1 (Ent1)
SREBPsSterol regulatory element-binding proteinSREBP/SREBPF1SREBP
 HamartinTSC1Tsc1
 TuberinTSC2gigas (gig)
 WD and tetratricopeptide repeats 1WDTC1adp