Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is a neuromuscular disease characterized by the degeneration of spinal cord motor neurons and subsequent muscle atrophy. Four types of SMA (types I thru IV) are caused by loss of the SMN1 gene. These four forms primarily differ in time of onset and severity, type I being the most severe and type IV the mildest. Which form the disease takes may be determined by the number of SMN2 genes present (see the Genetics Home Reference for more information). Fly stocks in the Bloomington collection that can be used to study SMA are listed here.

General Information links for SMA:

Human SMN1 and SMN2, Fly Smn
Relevant gene in stockFly disease model or related mutation or transgeneStk #Comments
SmnSmn[73Ao]4802Smn loss of function mutation, G202S.
SmnPBac{WH}Smn[f05960]18923Smn strong hypomorphic allele (WH insertion at amino acid K136)
SmnPBac{WH}Smn[f01109]85617This insertion in SMN causes neural defects and partial lethality.
SmnP{TRiP.JF02057}attP226288Expresses double-strand RNA for RNAi of Smn.
SmnP{TRiP.HMS05688}attP267950Expresses dsRNA for RNAi of Smn (FBgn0036641) under UAS control.
SmnP{TRiP.HMC03832}attP4055158Expresses dsRNA for RNAi of Smn (FBgn0036641) under UAS control.
SmnP{TRiP.GL00581}attP236621Expresses dsRNA for RNAi of Smn (FBgn0036641) under the control of UAS.